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Murcko scaffold

Ring system with 4 rings and 22 atoms

840 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
840
With full pages
15
Scaffold SMILES

O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 97 to 144 of 840 chemicals

3-(2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}ethoxy)propanoic acid chemical structure, C25H28N2O6, CAS 2171984-68-0
3-(2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}ethoxy)propanoic acid
CAS 2171984-68-0C25H28N2O6
4-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-methylpentanoic acid chemical structure, C27H32N2O5, CAS 2171896-14-1
4-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-methylpentanoic acid
CAS 2171896-14-1C27H32N2O5
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-hydroxy-2-methylpropanoic acid chemical structure, C25H28N2O6, CAS 2172522-24-4
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-hydroxy-2-methylpropanoic acid
CAS 2172522-24-4C25H28N2O6
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylbutanoic acid chemical structure, C26H30N2O5, CAS 2648971-69-9
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylbutanoic acid
CAS 2648971-69-9C26H30N2O5
3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methylbutanoic acid chemical structure, C25H28N2O5, CAS 2172382-99-7
3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methylbutanoic acid
CAS 2172382-99-7C25H28N2O5
5-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}pentanoic acid chemical structure, C26H30N2O5, CAS 2171988-30-8
5-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}pentanoic acid
CAS 2171988-30-8C26H30N2O5
2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(2-methylpropyl)formamido}acetic acid chemical structure, C26H30N2O5, CAS 2171988-46-6
2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(2-methylpropyl)formamido}acetic acid
CAS 2171988-46-6C26H30N2O5
(2R)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}propanoic acid chemical structure, C24H26N2O5, CAS 2171262-48-7
(2R)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}propanoic acid
CAS 2171262-48-7C24H26N2O5
3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-hydroxypropanoic acid chemical structure, C23H24N2O6, CAS 2172523-91-8
3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-hydroxypropanoic acid
CAS 2172523-91-8C23H24N2O6
2-({2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}methyl)pentanoic acid chemical structure, C27H32N2O5, CAS 2172507-91-2
2-({2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}methyl)pentanoic acid
CAS 2172507-91-2C27H32N2O5
7-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}heptanoic acid chemical structure, C28H34N2O5, CAS 2172328-47-9
7-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}heptanoic acid
CAS 2172328-47-9C28H34N2O5
(2S)-2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}propanoic acid chemical structure, C24H26N2O5, CAS 2171187-60-1
(2S)-2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}propanoic acid
CAS 2171187-60-1C24H26N2O5
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}heptanoic acid chemical structure, C28H34N2O5, CAS 2172196-13-1
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}heptanoic acid
CAS 2172196-13-1C28H34N2O5
(2S)-4-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-hydroxybutanoic acid chemical structure, C25H28N2O6, CAS 2171213-09-3
(2S)-4-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-hydroxybutanoic acid
CAS 2171213-09-3C25H28N2O6
2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutyl]acetic acid chemical structure, C23H25NO4, CAS 2141200-41-9
2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutyl]acetic acid
CAS 2141200-41-9C23H25NO4
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3,3,3-trifluoropropanoic acid chemical structure, C24H23F3N2O5, CAS 2171602-96-1
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3,3,3-trifluoropropanoic acid
CAS 2171602-96-1C24H23F3N2O5
(2S)-2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-(methylsulfanyl)butanoic acid chemical structure, C26H30N2O5S, CAS 2171186-59-5
(2S)-2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-(methylsulfanyl)butanoic acid
CAS 2171186-59-5C26H30N2O5S
4-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylbut-2-enoic acid chemical structure, C26H28N2O5, CAS 2172611-80-0
4-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylbut-2-enoic acid
CAS 2172611-80-0C26H28N2O5
(3R)-3-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}butanoic acid chemical structure, C24H26N2O5, CAS 2171228-86-5
(3R)-3-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}butanoic acid
CAS 2171228-86-5C24H26N2O5
2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-5-methylhex-4-enoic acid chemical structure, C27H30N2O5, CAS 2171291-24-8
2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-5-methylhex-4-enoic acid
CAS 2171291-24-8C27H30N2O5
5-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}pentanoic acid chemical structure, C26H30N2O5, CAS 2171154-44-0
5-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}pentanoic acid
CAS 2171154-44-0C26H30N2O5
3-({[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)pentanoic acid chemical structure, C26H30N2O5, CAS 2171419-83-1
3-({[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)pentanoic acid
CAS 2171419-83-1C26H30N2O5
3-{N-Ethyl-1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}butanoic acid chemical structure, C26H30N2O5, CAS 2171433-34-2
3-{N-Ethyl-1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}butanoic acid
CAS 2171433-34-2C26H30N2O5
3-({2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}methyl)-4-methylpentanoic acid chemical structure, C28H34N2O5, CAS 2171975-44-1
3-({2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}methyl)-4-methylpentanoic acid
CAS 2171975-44-1C28H34N2O5