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Murcko scaffold

Ring system with 4 rings and 22 atoms

840 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
840
With full pages
15
Scaffold SMILES

O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 625 to 672 of 840 chemicals

2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(prop-2-en-1-yl)formamido}acetic acid chemical structure, C25H26N2O5, CAS 2172146-90-4
2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(prop-2-en-1-yl)formamido}acetic acid
CAS 2172146-90-4C25H26N2O5
2-{N-Ethyl-1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methylpropanoic acid chemical structure, C26H30N2O5, CAS 2172527-16-9
2-{N-Ethyl-1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methylpropanoic acid
CAS 2172527-16-9C26H30N2O5
2-[N-(Butan-2-yl)-1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido]acetic acid chemical structure, C26H30N2O5, CAS 2172527-21-6
2-[N-(Butan-2-yl)-1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido]acetic acid
CAS 2172527-21-6C26H30N2O5
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methylpentanoic acid chemical structure, C26H30N2O5, CAS 2171277-16-8
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methylpentanoic acid
CAS 2171277-16-8C26H30N2O5
3-{N-Ethyl-2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid chemical structure, C27H32N2O5, CAS 2172529-44-9
3-{N-Ethyl-2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid
CAS 2172529-44-9C27H32N2O5
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylpropanoic acid chemical structure, C25H28N2O5, CAS 2172027-91-5
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylpropanoic acid
CAS 2172027-91-5C25H28N2O5
2-(2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}acetamido)acetic acid chemical structure, C25H27N3O6, CAS 2171804-42-3
2-(2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}acetamido)acetic acid
CAS 2171804-42-3C25H27N3O6
3-(2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}ethoxy)propanoic acid chemical structure, C26H30N2O6, CAS 2172394-35-1
3-(2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}ethoxy)propanoic acid
CAS 2172394-35-1C26H30N2O6
2-({2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}methyl)-2-methylbutanoic acid chemical structure, C27H32N2O5, CAS 2171939-37-8
2-({2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}methyl)-2-methylbutanoic acid
CAS 2171939-37-8C27H32N2O5
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4,4-dimethylpentanoic acid chemical structure, C27H32N2O5, CAS 2171481-13-1
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4,4-dimethylpentanoic acid
CAS 2171481-13-1C27H32N2O5
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(prop-2-en-1-yl)acetamido}acetic acid chemical structure, C26H28N2O5, CAS 2171801-11-7
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(prop-2-en-1-yl)acetamido}acetic acid
CAS 2171801-11-7C26H28N2O5
2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-methylcyclobutyl]acetic acid chemical structure, C22H23NO4, CAS 2153282-05-2
2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-methylcyclobutyl]acetic acid
CAS 2153282-05-2C22H23NO4
(2R)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-(methylsulfanyl)butanoic acid chemical structure, C26H30N2O5S, CAS 2171187-23-6
(2R)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-(methylsulfanyl)butanoic acid
CAS 2171187-23-6C26H30N2O5S
3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}-2-methylpropanoic acid chemical structure, C26H30N2O5, CAS 2172123-75-8
3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}-2-methylpropanoic acid
CAS 2172123-75-8C26H30N2O5
2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(2,2,2-trifluoroethyl)formamido}acetic acid chemical structure, C24H23F3N2O5, CAS 2172454-74-7
2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(2,2,2-trifluoroethyl)formamido}acetic acid
CAS 2172454-74-7C24H23F3N2O5
7-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}heptanoic acid chemical structure, C27H32N2O5, CAS 2172179-40-5
7-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}heptanoic acid
CAS 2172179-40-5C27H32N2O5
3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}pentanoic acid chemical structure, C25H28N2O5, CAS 2172290-59-2
3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}pentanoic acid
CAS 2172290-59-2C25H28N2O5
2-(2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}ethoxy)acetic acid chemical structure, C25H28N2O6, CAS 2171860-85-6
2-(2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}ethoxy)acetic acid
CAS 2171860-85-6C25H28N2O6
3-{N-Ethyl-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylpropanoic acid chemical structure, C27H32N2O5, CAS 2172291-67-5
3-{N-Ethyl-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylpropanoic acid
CAS 2172291-67-5C27H32N2O5
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-5-methoxypentanoic acid chemical structure, C27H32N2O6, CAS 2171778-04-2
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-5-methoxypentanoic acid
CAS 2171778-04-2C27H32N2O6
3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methylpentanoic acid chemical structure, C26H30N2O5, CAS 2171885-78-0
3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methylpentanoic acid
CAS 2171885-78-0C26H30N2O5
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-(methylsulfanyl)butanoic acid chemical structure, C25H28N2O5S, CAS 2171231-04-0
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-(methylsulfanyl)butanoic acid
CAS 2171231-04-0C25H28N2O5S
(3R)-3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}heptanoic acid chemical structure, C27H32N2O5, CAS 2171142-85-9
(3R)-3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}heptanoic acid
CAS 2171142-85-9C27H32N2O5
4-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}butanoic acid chemical structure, C25H28N2O5, CAS 2172208-79-4
4-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}butanoic acid
CAS 2172208-79-4C25H28N2O5