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Murcko scaffold

Ring system with 2 rings and 11 atoms

52 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
52
With full pages
3
Scaffold SMILES

c1csc(C2CCOCC2)c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1csc(C2CCOCC2)c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 52 chemicals

N-(2,2-Dimethoxyethyl)-4-(thiophen-2-yl)tetrahydro-2H-pyran-4-carboxamide chemical structure, C14H21NO4S, CAS 877650-48-1
N-(2,2-Dimethoxyethyl)-4-(thiophen-2-yl)tetrahydro-2H-pyran-4-carboxamide
CAS 877650-48-1C14H21NO4S
4-(5-Bromothiophen-2-yl)oxan-4-ol chemical structure, C9H11BrO2S, CAS 140618-92-4
4-(5-Bromothiophen-2-yl)oxan-4-ol
CAS 140618-92-4C9H11BrO2S
4-(Thiophen-2-yl)oxane-4-carboxylic acid chemical structure, C10H12O3S, CAS 880166-18-7
4-(Thiophen-2-yl)oxane-4-carboxylic acid
CAS 880166-18-7C10H12O3S
4-(Thiophen-2-yl)oxane-4-carbonyl chloride chemical structure, C10H11ClO2S, CAS 906352-92-9
4-(Thiophen-2-yl)oxane-4-carbonyl chloride
CAS 906352-92-9C10H11ClO2S
4-(Thiophen-2-yl)oxane-4-carbaldehyde chemical structure, C10H12O2S, CAS 906352-93-0
4-(Thiophen-2-yl)oxane-4-carbaldehyde
CAS 906352-93-0C10H12O2S
4-Isocyanato-4-(thiophen-2-yl)oxane chemical structure, C10H11NO2S, CAS 926921-63-3
4-Isocyanato-4-(thiophen-2-yl)oxane
CAS 926921-63-3C10H11NO2S
(4-Thien-2-yltetrahydropyran-4-yl)methanol chemical structure, C10H14O2S, CAS 906352-94-1
(4-Thien-2-yltetrahydropyran-4-yl)methanol
CAS 906352-94-1C10H14O2S
(4-Thien-2-yltetrahydropyran-4-yl)methylamine chemical structure, C10H15NOS, CAS 906422-74-0
(4-Thien-2-yltetrahydropyran-4-yl)methylamine
CAS 906422-74-0C10H15NOS
Methyl({[4-(thiophen-2-yl)oxan-4-yl]methyl})amine chemical structure, C11H17NOS, CAS 916790-87-9
Methyl({[4-(thiophen-2-yl)oxan-4-yl]methyl})amine
CAS 916790-87-9C11H17NOS
N1-(tert-butyl)-N2-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)oxalamide chemical structure, C16H24N2O3S, CAS 1091417-27-4
N1-(tert-butyl)-N2-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)oxalamide
CAS 1091417-27-4C16H24N2O3S
N1-(2-methoxyethyl)-N2-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)oxalamide chemical structure, C15H22N2O4S, CAS 1091417-32-1
N1-(2-methoxyethyl)-N2-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)oxalamide
CAS 1091417-32-1C15H22N2O4S
N-((4-(Thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)pivalamide chemical structure, C15H23NO2S, CAS 1203296-78-9
N-((4-(Thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)pivalamide
CAS 1203296-78-9C15H23NO2S
1-(2-Methoxyethyl)-3-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)urea chemical structure, C14H22N2O3S, CAS 1207011-77-5
1-(2-Methoxyethyl)-3-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)urea
CAS 1207011-77-5C14H22N2O3S
Ethyl ((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)carbamate chemical structure, C13H19NO3S, CAS 1206994-09-3
Ethyl ((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)carbamate
CAS 1206994-09-3C13H19NO3S
2-Methoxy-N-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)acetamide chemical structure, C13H19NO3S, CAS 1207033-06-4
2-Methoxy-N-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)acetamide
CAS 1207033-06-4C13H19NO3S
2-Ethoxy-N-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)acetamide chemical structure, C14H21NO3S, CAS 1208636-30-9
2-Ethoxy-N-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)acetamide
CAS 1208636-30-9C14H21NO3S
2-Propyl-N-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)pentanamide chemical structure, C18H29NO2S, CAS 1208491-00-2
2-Propyl-N-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)pentanamide
CAS 1208491-00-2C18H29NO2S
N-((4-(Thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)ethanesulfonamide chemical structure, C12H19NO3S2, CAS 1209574-36-6
N-((4-(Thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)ethanesulfonamide
CAS 1209574-36-6C12H19NO3S2
N-((4-(Thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)propane-1-sulfonamide chemical structure, C13H21NO3S2, CAS 1208846-75-6
N-((4-(Thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)propane-1-sulfonamide
CAS 1208846-75-6C13H21NO3S2
2-Methyl-N-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)propane-1-sulfonamide chemical structure, C14H23NO3S2, CAS 1210799-95-3
2-Methyl-N-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)propane-1-sulfonamide
CAS 1210799-95-3C14H23NO3S2
N-((4-(Thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)butane-1-sulfonamide chemical structure, C14H23NO3S2, CAS 1211144-28-3
N-((4-(Thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)butane-1-sulfonamide
CAS 1211144-28-3C14H23NO3S2
1-Ethyl-3-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)urea chemical structure, C13H20N2O2S, CAS 1210497-18-9
1-Ethyl-3-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)urea
CAS 1210497-18-9C13H20N2O2S
1-Allyl-3-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)urea chemical structure, C14H20N2O2S, CAS 1209674-74-7
1-Allyl-3-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)urea
CAS 1209674-74-7C14H20N2O2S
1-Isopropyl-3-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)urea chemical structure, C14H22N2O2S, CAS 1211284-83-1
1-Isopropyl-3-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)urea
CAS 1211284-83-1C14H22N2O2S