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Murcko scaffold

1H,2H,3H,4H-Pyrido(2,3-b)pyrazine scaffold

92 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
92
With full pages
12
Scaffold SMILES

c1cnc2c(c1)NCCN2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1H,2H,3H,4H-Pyrido(2,3-b)pyrazine page
Murcko scaffold c1cnc2c(c1)NCCN2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 92 chemicals

2,3-Dimethyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazine chemical structure, C9H13N3, CAS 35808-54-9
2,3-Dimethyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazine
CAS 35808-54-9C9H13N3
(2R,3R)-2,3-Diethyl-1,2,3,4-tetrahydropyrido[2,3-B]pyrazine chemical structure, C11H17N3, CAS 59352-68-0
(2R,3R)-2,3-Diethyl-1,2,3,4-tetrahydropyrido[2,3-B]pyrazine
CAS 59352-68-0C11H17N3
(2R,3R)-2,3-Bis(ethenyl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine chemical structure, C11H13N3, CAS 59352-69-1
(2R,3R)-2,3-Bis(ethenyl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine
CAS 59352-69-1C11H13N3
1H,2H,3H,4H-Pyrido(2,3-b)pyrazine chemical structure, C7H9N3, CAS 35808-40-3
1H,2H,3H,4H-Pyrido(2,3-b)pyrazine
CAS 35808-40-3C7H9N3
2-Methyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazine chemical structure, C8H11N3, CAS 74983-03-2
2-Methyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazine
CAS 74983-03-2C8H11N3
3-Methyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazine chemical structure, C8H11N3, CAS 74983-05-4
3-Methyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazine
CAS 74983-05-4C8H11N3
1-(4-Methyl-3,4-dihydropyrido[2,3-b]pyrazin-1(2H)-yl)ethanone chemical structure, C10H13N3O, CAS 138768-66-8
1-(4-Methyl-3,4-dihydropyrido[2,3-b]pyrazin-1(2H)-yl)ethanone
CAS 138768-66-8C10H13N3O
4-Methyl-3,4-dihydropyrido[2,3-B]pyrazine-1(2H)-carbaldehyde chemical structure, C9H11N3O, CAS 138768-67-9
4-Methyl-3,4-dihydropyrido[2,3-B]pyrazine-1(2H)-carbaldehyde
CAS 138768-67-9C9H11N3O
1,4-Dimethyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine chemical structure, C9H13N3, CAS 72119-50-7
1,4-Dimethyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine
CAS 72119-50-7C9H13N3
1,4-Diethyl-1,2,3,4-tetrahydropyrido[2,3-B]pyrazine chemical structure, C11H17N3, CAS 72128-57-5
1,4-Diethyl-1,2,3,4-tetrahydropyrido[2,3-B]pyrazine
CAS 72128-57-5C11H17N3
tert-Butyl 1,6-dimethyl-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxylate chemical structure, C14H21N3O2, CAS 689259-33-4
tert-Butyl 1,6-dimethyl-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxylate
CAS 689259-33-4C14H21N3O2
tert-Butyl 6-(2-ethoxy-2-oxoethyl)-1-methyl-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxylate chemical structure, C17H25N3O4, CAS 689259-34-5
tert-Butyl 6-(2-ethoxy-2-oxoethyl)-1-methyl-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxylate
CAS 689259-34-5C17H25N3O4
tert-Butyl 6-(2-hydroxyethyl)-1-methyl-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxylate chemical structure, C15H23N3O3, CAS 722549-91-9
tert-Butyl 6-(2-hydroxyethyl)-1-methyl-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxylate
CAS 722549-91-9C15H23N3O3
1,6-Dimethyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine chemical structure, C9H13N3, CAS 689259-32-3
1,6-Dimethyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine
CAS 689259-32-3C9H13N3
2-(1-Methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-yl)ethanol chemical structure, C10H15N3O, CAS 689259-29-8
2-(1-Methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-yl)ethanol
CAS 689259-29-8C10H15N3O
6-Chloro-1H,2H,3H,4H-pyrido(2,3-b)pyrazine chemical structure, C7H8ClN3, CAS 1210129-64-8
6-Chloro-1H,2H,3H,4H-pyrido(2,3-b)pyrazine
CAS 1210129-64-8C7H8ClN3
1-(7-Bromo-4-methyl-3,4-dihydropyrido[2,3-b]pyrazin-1(2H)-yl)-2,2-dimethylpropan-1-one chemical structure, C13H18BrN3O, CAS 1142192-65-1
1-(7-Bromo-4-methyl-3,4-dihydropyrido[2,3-b]pyrazin-1(2H)-yl)-2,2-dimethylpropan-1-one
CAS 1142192-65-1C13H18BrN3O
4-Methyl-1H,2H,3H,4H-pyrido(2,3-b)pyrazine chemical structure, C8H11N3, CAS 928118-20-1
4-Methyl-1H,2H,3H,4H-pyrido(2,3-b)pyrazine
CAS 928118-20-1C8H11N3
4-Ethyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine chemical structure, C9H13N3, CAS 1058704-79-2
4-Ethyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine
CAS 1058704-79-2C9H13N3
7-Bromo-4-methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine chemical structure, C8H10BrN3, CAS 1211581-98-4
7-Bromo-4-methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine
CAS 1211581-98-4C8H10BrN3
7-Bromo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine chemical structure, C7H8BrN3, CAS 52333-31-0
7-Bromo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine
CAS 52333-31-0C7H8BrN3
6-Methoxy-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine chemical structure, C8H11N3O, CAS 1260862-06-3
6-Methoxy-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine
CAS 1260862-06-3C8H11N3O
4-Methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-amine chemical structure, C8H12N4, CAS 1314979-31-1
4-Methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-amine
CAS 1314979-31-1C8H12N4
6-Methoxy-4-methyl-1H,2H,3H,4H-pyrido(2,3-b)pyrazine chemical structure, C9H13N3O, CAS 1314922-89-8
6-Methoxy-4-methyl-1H,2H,3H,4H-pyrido(2,3-b)pyrazine
CAS 1314922-89-8C9H13N3O