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Murcko scaffold

5,6,7,8-Tetrahydroisoquinoline scaffold

224 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
224
With full pages
24
Scaffold SMILES

c1cc2c(cn1)CCCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 5,6,7,8-Tetrahydroisoquinoline page
Murcko scaffold c1cc2c(cn1)CCCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 224 chemicals

4-Isoquinolinecarbonitrile, 5,6,7,8-tetrahydro-3-(2-hydroxy-3-(1-methylethyl)amino)propoxy)-,monohydrochloride chemical structure, C16H24ClN3O2, CAS 103607-59-6
4-Isoquinolinecarbonitrile, 5,6,7,8-tetrahydro-3-(2-hydroxy-3-(1-methylethyl)amino)propoxy)-,monohydrochloride
CAS 103607-59-6C16H24ClN3O2
3-Amino-5,6,7,8-tetrahydro-4-isoquinolinecarbonitrile chemical structure, C10H11N3, CAS 53661-19-1
3-Amino-5,6,7,8-tetrahydro-4-isoquinolinecarbonitrile
CAS 53661-19-1C10H11N3
5,6,7,8-Tetrahydroisoquinoline chemical structure, C9H11N, CAS 36556-06-6
5,6,7,8-Tetrahydroisoquinoline
CAS 36556-06-6C9H11N
3-Amino-7-methyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile chemical structure, C11H13N3, CAS 146353-62-0
3-Amino-7-methyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS 146353-62-0C11H13N3
3-Chloro-1,8,8-trimethyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile chemical structure, C13H15ClN2, CAS 887571-73-5
3-Chloro-1,8,8-trimethyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS 887571-73-5C13H15ClN2
1-Butyl-3-(2-hydroxyethylamino)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile chemical structure, C16H23N3O, CAS 371203-04-2
1-Butyl-3-(2-hydroxyethylamino)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS 371203-04-2C16H23N3O
4-Isoquinolinecarbonitrile, 5,6,7,8-tetrahydro-3-(methylthio)- chemical structure, C11H12N2S, CAS 839680-24-9
4-Isoquinolinecarbonitrile, 5,6,7,8-tetrahydro-3-(methylthio)-
CAS 839680-24-9C11H12N2S
4-Isoquinolinecarboxylic acid, 5,6,7,8-tetrahydro-3-amino- chemical structure, C10H12N2O2, CAS 130688-31-2
4-Isoquinolinecarboxylic acid, 5,6,7,8-tetrahydro-3-amino-
CAS 130688-31-2C10H12N2O2
3-Amino-5,6,7,8-tetrahydro-4-isoquinolinecarboxamide chemical structure, C10H13N3O, CAS 130688-32-3
3-Amino-5,6,7,8-tetrahydro-4-isoquinolinecarboxamide
CAS 130688-32-3C10H13N3O
(4-Cyano-1-ethyl-5,6,7,8-tetrahydro-isoquinolin-3-ylsulfanyl)-acetic acid chemical structure, C14H16N2O2S, CAS 95546-61-5
(4-Cyano-1-ethyl-5,6,7,8-tetrahydro-isoquinolin-3-ylsulfanyl)-acetic acid
CAS 95546-61-5C14H16N2O2S
3-Chloro-1-ethyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile chemical structure, C12H13ClN2, CAS 53661-34-0
3-Chloro-1-ethyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS 53661-34-0C12H13ClN2
1-Ethyl-3-(3-hydroxypropylamino)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile chemical structure, C15H21N3O, CAS 373377-33-4
1-Ethyl-3-(3-hydroxypropylamino)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS 373377-33-4C15H21N3O
1-Ethyl-3-(2-hydroxyethylamino)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile chemical structure, C14H19N3O, CAS 374086-16-5
1-Ethyl-3-(2-hydroxyethylamino)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS 374086-16-5C14H19N3O
3-Chloro-1-methyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile chemical structure, C11H11ClN2, CAS 17012-31-6
3-Chloro-1-methyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS 17012-31-6C11H11ClN2
1-Butyl-3-chloro-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile chemical structure, C14H17ClN2, CAS 361534-72-7
1-Butyl-3-chloro-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS 361534-72-7C14H17ClN2
3-(2-Hydroxyethylamino)-1-propan-2-yl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile chemical structure, C15H21N3O, CAS 371931-23-6
3-(2-Hydroxyethylamino)-1-propan-2-yl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS 371931-23-6C15H21N3O
3,5-Dimethyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile chemical structure, C12H14N2, CAS 242474-46-0
3,5-Dimethyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS 242474-46-0C12H14N2
3-Chloro-1-isopropyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile chemical structure, C13H15ClN2, CAS 361534-70-5
3-Chloro-1-isopropyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS 361534-70-5C13H15ClN2
2-[(4-Cyano-1-ethyl-5,6,7,8-tetrahydroisoquinolin-3-yl)sulfanyl]-N,N-diethylacetamide chemical structure, C18H25N3OS, CAS 385786-71-0
2-[(4-Cyano-1-ethyl-5,6,7,8-tetrahydroisoquinolin-3-yl)sulfanyl]-N,N-diethylacetamide
CAS 385786-71-0C18H25N3OS
Ethyl [(4-cyano-1-ethyl-5,6,7,8-tetrahydro-3-isoquinolinyl)thio]acetate chemical structure, C16H20N2O2S, CAS 95546-60-4
Ethyl [(4-cyano-1-ethyl-5,6,7,8-tetrahydro-3-isoquinolinyl)thio]acetate
CAS 95546-60-4C16H20N2O2S
3-(2-Methoxyethylamino)-1-(2-methylpropyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile chemical structure, C17H25N3O, CAS 903202-79-9
3-(2-Methoxyethylamino)-1-(2-methylpropyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS 903202-79-9C17H25N3O
3-[3-(Dimethylamino)propylamino]-1-propan-2-yl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile chemical structure, C18H28N4, CAS 904006-63-9
3-[3-(Dimethylamino)propylamino]-1-propan-2-yl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS 904006-63-9C18H28N4
1-Butyl-3-(3-hydroxypropylamino)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile chemical structure, C17H25N3O, CAS 903851-81-0
1-Butyl-3-(3-hydroxypropylamino)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS 903851-81-0C17H25N3O
1-Ethyl-3-(3-methoxypropylamino)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile chemical structure, C16H23N3O, CAS 903206-54-2
1-Ethyl-3-(3-methoxypropylamino)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
CAS 903206-54-2C16H23N3O