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Murcko scaffold

Ring system with 2 rings and 15 atoms

10 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
10
With full pages
3
Scaffold SMILES

O=C(C=Cc1cccs1)Nc1nccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1cccs1)Nc1nccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

N,N,4-trimethyl-2-[[(E)-3-thiophen-2-ylprop-2-enoyl]amino]-1,3-thiazole-5-carboxamide chemical structure, C14H15N3O2S2, CAS 545370-90-9
N,N,4-trimethyl-2-[[(E)-3-thiophen-2-ylprop-2-enoyl]amino]-1,3-thiazole-5-carboxamide
CAS 545370-90-9C14H15N3O2S2
(2E)-N-(1,3-Thiazol-2-yl)-3-(thiophen-2-yl)prop-2-enamide chemical structure, C10H8N2OS2, CAS 117837-26-0
(2E)-N-(1,3-Thiazol-2-yl)-3-(thiophen-2-yl)prop-2-enamide
CAS 117837-26-0C10H8N2OS2
(2E)-2-Cyano-N-1,3-thiazol-2-yl-3-(2-thienyl)acrylamide chemical structure, C11H7N3OS2, CAS 667413-46-9
(2E)-2-Cyano-N-1,3-thiazol-2-yl-3-(2-thienyl)acrylamide
CAS 667413-46-9C11H7N3OS2
Ethyl 2-[[1-oxo-3-(2-thienyl)-2-propen-1-yl]amino]-4-thiazolecarboxylate chemical structure, C13H12N2O3S2, CAS 681250-10-2
Ethyl 2-[[1-oxo-3-(2-thienyl)-2-propen-1-yl]amino]-4-thiazolecarboxylate
CAS 681250-10-2C13H12N2O3S2
(E)-N-(5-Acetyl-4-methylthiazol-2-yl)-3-(thiophen-2-yl)acrylamide chemical structure, C13H12N2O2S2, CAS 476308-17-5
(E)-N-(5-Acetyl-4-methylthiazol-2-yl)-3-(thiophen-2-yl)acrylamide
CAS 476308-17-5C13H12N2O2S2
(E)-Ethyl 4-methyl-2-(3-(5-nitrothiophen-2-yl)acrylamido)thiazole-5-carboxylate chemical structure, C14H13N3O5S2, CAS 476319-80-9
(E)-Ethyl 4-methyl-2-(3-(5-nitrothiophen-2-yl)acrylamido)thiazole-5-carboxylate
CAS 476319-80-9C14H13N3O5S2
2-Cyano-3-(5-methylthiophen-2-yl)-N-(1,3-thiazol-2-yl)prop-2-enamide chemical structure, C12H9N3OS2, CAS 849057-48-3
2-Cyano-3-(5-methylthiophen-2-yl)-N-(1,3-thiazol-2-yl)prop-2-enamide
CAS 849057-48-3C12H9N3OS2
(Z)-Ethyl 3,4-dimethyl-2-(((E)-3-(thiophen-2-yl)acryloyl)imino)-2,3-dihydrothiazole-5-carboxylate chemical structure, C15H16N2O3S2, CAS 393838-98-7
(Z)-Ethyl 3,4-dimethyl-2-(((E)-3-(thiophen-2-yl)acryloyl)imino)-2,3-dihydrothiazole-5-carboxylate
CAS 393838-98-7C15H16N2O3S2
(E)-Ethyl 3,4-dimethyl-2-(((E)-3-(5-nitrothiophen-2-yl)acryloyl)imino)-2,3-dihydrothiazole-5-carboxylate chemical structure, C15H15N3O5S2, CAS 476641-51-7
(E)-Ethyl 3,4-dimethyl-2-(((E)-3-(5-nitrothiophen-2-yl)acryloyl)imino)-2,3-dihydrothiazole-5-carboxylate
CAS 476641-51-7C15H15N3O5S2
(E)-N-(4-(2-(Methylamino)-2-oxoethyl)thiazol-2-yl)-3-(thiophen-2-yl)acrylamide chemical structure, C13H13N3O2S2, CAS 1203440-09-8
(E)-N-(4-(2-(Methylamino)-2-oxoethyl)thiazol-2-yl)-3-(thiophen-2-yl)acrylamide
CAS 1203440-09-8C13H13N3O2S2