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Murcko scaffold

Ring system with 3 rings and 15 atoms

107 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
15
Chemicals
107
With full pages
11
Scaffold SMILES

c1ccc(-c2ccc3c[nH]nc3n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2ccc3c[nH]nc3n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 107 chemicals

6-(3,4-Dichlorophenyl)-2H-pyrazolo[3,4-b]pyridin-3-amine chemical structure, C12H8Cl2N4, CAS 685107-56-6
6-(3,4-Dichlorophenyl)-2H-pyrazolo[3,4-b]pyridin-3-amine
CAS 685107-56-6C12H8Cl2N4
6-Phenyl-1-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C16H15N3O2, CAS 851175-95-6
6-Phenyl-1-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS 851175-95-6C16H15N3O2
1,3-Dimethyl-6-(3-nitrophenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C15H12N4O4, CAS 886503-31-7
1,3-Dimethyl-6-(3-nitrophenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS 886503-31-7C15H12N4O4
6-(4-Chlorophenyl)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C15H12ClN3O2, CAS 886503-59-9
6-(4-Chlorophenyl)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS 886503-59-9C15H12ClN3O2
6-(4-Methylphenyl)-1-(propan-2-yl)-1H-pyrazolo(3,4-b)pyridine-4-carboxylic acid chemical structure, C17H17N3O2, CAS 924213-53-6
6-(4-Methylphenyl)-1-(propan-2-yl)-1H-pyrazolo(3,4-b)pyridine-4-carboxylic acid
CAS 924213-53-6C17H17N3O2
1-Isopropyl-6-(2-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C17H17N3O2, CAS 924243-72-1
1-Isopropyl-6-(2-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS 924243-72-1C17H17N3O2
1-Ethyl-6-phenyl-1H-pyrazolo(3,4-b)pyridine-4-carboxylic acid chemical structure, C15H13N3O2, CAS 924118-62-7
1-Ethyl-6-phenyl-1H-pyrazolo(3,4-b)pyridine-4-carboxylic acid
CAS 924118-62-7C15H13N3O2
1,3-Dimethyl-6-phenyl-1H-pyrazolo(3,4-b)pyridine-4-carboxylic acid chemical structure, C15H13N3O2, CAS 924014-94-8
1,3-Dimethyl-6-phenyl-1H-pyrazolo(3,4-b)pyridine-4-carboxylic acid
CAS 924014-94-8C15H13N3O2
6-(4-Fluorophenyl)-1,3-dimethyl-1H-pyrazolo-[3,4-b]-pyridine-4-carboxylic acid chemical structure, C15H12FN3O2, CAS 941234-32-8
6-(4-Fluorophenyl)-1,3-dimethyl-1H-pyrazolo-[3,4-b]-pyridine-4-carboxylic acid
CAS 941234-32-8C15H12FN3O2
6-(4-Methoxyphenyl)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C16H15N3O3, CAS 937598-82-8
6-(4-Methoxyphenyl)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS 937598-82-8C16H15N3O3
1,3-Dimethyl-6-(4-methylphenyl)-1H-pyrazolo(3,4-b)pyridine-4-carboxylic acid chemical structure, C16H15N3O2, CAS 937598-72-6
1,3-Dimethyl-6-(4-methylphenyl)-1H-pyrazolo(3,4-b)pyridine-4-carboxylic acid
CAS 937598-72-6C16H15N3O2
6-(4-Bromophenyl)-1,3-dimethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine chemical structure, C15H11BrF3N3, CAS 834901-35-8
6-(4-Bromophenyl)-1,3-dimethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
CAS 834901-35-8C15H11BrF3N3
6-(4-Methoxyphenyl)-1,3-dimethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine chemical structure, C16H14F3N3O, CAS 834896-20-7
6-(4-Methoxyphenyl)-1,3-dimethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
CAS 834896-20-7C16H14F3N3O
Methyl 6-(4-chlorophenyl)-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate chemical structure, C17H16ClN3O2, CAS 832741-63-6
Methyl 6-(4-chlorophenyl)-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate
CAS 832741-63-6C17H16ClN3O2
1-Ethyl-6-(2-methoxyphenyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine chemical structure, C17H16F3N3O, CAS 832742-01-5
1-Ethyl-6-(2-methoxyphenyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
CAS 832742-01-5C17H16F3N3O
6-[4-(Difluoromethoxy)phenyl]-1-ethyl-3-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine chemical structure, C17H14F5N3O, CAS 832742-09-3
6-[4-(Difluoromethoxy)phenyl]-1-ethyl-3-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
CAS 832742-09-3C17H14F5N3O
1-Ethyl-6-(3-methoxyphenyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine chemical structure, C17H16F3N3O, CAS 832742-28-6
1-Ethyl-6-(3-methoxyphenyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
CAS 832742-28-6C17H16F3N3O
6-(3,4-Dichlorophenyl)-4-(difluoromethyl)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine chemical structure, C15H11Cl2F2N3, CAS 834896-07-0
6-(3,4-Dichlorophenyl)-4-(difluoromethyl)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine
CAS 834896-07-0C15H11Cl2F2N3
Methyl 6-(4-chlorophenyl)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate chemical structure, C16H14ClN3O2, CAS 834896-71-8
Methyl 6-(4-chlorophenyl)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate
CAS 834896-71-8C16H14ClN3O2
Methyl 1,3-dimethyl-6-(3-nitrophenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate chemical structure, C16H14N4O4, CAS 834897-24-4
Methyl 1,3-dimethyl-6-(3-nitrophenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate
CAS 834897-24-4C16H14N4O4
6-(4-tert-Butylphenyl)-1,3-dimethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine chemical structure, C19H20F3N3, CAS 834897-37-9
6-(4-tert-Butylphenyl)-1,3-dimethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
CAS 834897-37-9C19H20F3N3
4-[Chloro(difluoro)methyl]-6-(4-fluorophenyl)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine chemical structure, C15H11ClF3N3, CAS 834899-19-3
4-[Chloro(difluoro)methyl]-6-(4-fluorophenyl)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine
CAS 834899-19-3C15H11ClF3N3
6-[3-(Difluoromethoxy)phenyl]-1,3-dimethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine chemical structure, C16H12F5N3O, CAS 834899-42-2
6-[3-(Difluoromethoxy)phenyl]-1,3-dimethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
CAS 834899-42-2C16H12F5N3O
Methyl 1-butyl-3-methyl-6-(3-nitrophenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate chemical structure, C19H20N4O4, CAS 866814-41-7
Methyl 1-butyl-3-methyl-6-(3-nitrophenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate
CAS 866814-41-7C19H20N4O4