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Murcko scaffold

Ring system with 3 rings and 16 atoms

124 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 16
Chemicals: 124
With full pages: 13

Scaffold SMILES

O=c1c2c(ncn1-c1ccccc1)CCS2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1c2c(ncn1-c1ccccc1)CCS2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 124 chemicals

2-[(4-Oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide chemical structure, C14H13N3O2S2, CAS 686770-63-8

2-[(4-Oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide

CAS 686770-63-8C₁₄H₁₃N₃O₂S₂

Ethyl 2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetate chemical structure, C16H16N2O3S2, CAS 686770-97-8

Ethyl 2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetate

CAS 686770-97-8C₁₆H₁₆N₂O₃S₂

2-[[3-(4-Methylphenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]acetamide chemical structure, C15H15N3O2S2, CAS 686771-52-8

2-[[3-(4-Methylphenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]acetamide

CAS 686771-52-8C₁₅H₁₅N₃O₂S₂

2-(Ethylthio)-3-(p-tolyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one chemical structure, C15H16N2OS2, CAS 686771-63-1

2-(Ethylthio)-3-(p-tolyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one

CAS 686771-63-1C₁₅H₁₆N₂OS₂

2-(Isopropylthio)-3-(p-tolyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one chemical structure, C16H18N2OS2, CAS 686771-65-3

2-(Isopropylthio)-3-(p-tolyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one

CAS 686771-65-3C₁₆H₁₈N₂OS₂

3-(2-Methoxyphenyl)-2-methylsulfanyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-one chemical structure, C14H14N2O2S2, CAS 686772-28-1

3-(2-Methoxyphenyl)-2-methylsulfanyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-one

CAS 686772-28-1C₁₄H₁₄N₂O₂S₂

3-(4-Ethoxyphenyl)-2-(methylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one chemical structure, C15H16N2O2S2, CAS 686772-57-6

3-(4-Ethoxyphenyl)-2-(methylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one

CAS 686772-57-6C₁₅H₁₆N₂O₂S₂

3-(4-Ethoxyphenyl)-2-(ethylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one chemical structure, C16H18N2O2S2, CAS 686772-58-7

3-(4-Ethoxyphenyl)-2-(ethylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one

CAS 686772-58-7C₁₆H₁₈N₂O₂S₂

3-(4-Ethoxyphenyl)-2-(isopropylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one chemical structure, C17H20N2O2S2, CAS 686772-60-1

3-(4-Ethoxyphenyl)-2-(isopropylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one

CAS 686772-60-1C₁₇H₂₀N₂O₂S₂

3-(4-Chlorophenyl)-2-(ethylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one chemical structure, C14H13ClN2OS2, CAS 687564-40-5

3-(4-Chlorophenyl)-2-(ethylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one

CAS 687564-40-5C₁₄H₁₃ClN₂OS₂

2-(Methylthio)-3-(4-nitrophenyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one chemical structure, C13H11N3O3S2, CAS 687569-08-0

2-(Methylthio)-3-(4-nitrophenyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one

CAS 687569-08-0C₁₃H₁₁N₃O₃S₂

2-(Ethylthio)-3-(4-nitrophenyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one chemical structure, C14H13N3O3S2, CAS 687569-11-5

2-(Ethylthio)-3-(4-nitrophenyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one

CAS 687569-11-5C₁₄H₁₃N₃O₃S₂

BC11-38 chemical structure, C15H16N2OS2, CAS 686770-80-9

CAS 686770-80-9C₁₅H₁₆N₂OS₂

3-(4-Methylphenyl)-2-propylsulfanyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-one chemical structure, C16H18N2OS2, CAS 686771-64-2

3-(4-Methylphenyl)-2-propylsulfanyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-one

CAS 686771-64-2C₁₆H₁₈N₂OS₂

2-(Ethylthio)-3-(2-methoxyphenyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one chemical structure, C15H16N2O2S2, CAS 850915-30-9

2-(Ethylthio)-3-(2-methoxyphenyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one

CAS 850915-30-9C₁₅H₁₆N₂O₂S₂

3-(4-Ethoxyphenyl)-2-(propylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one chemical structure, C17H20N2O2S2, CAS 686772-59-8

3-(4-Ethoxyphenyl)-2-(propylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one

CAS 686772-59-8C₁₇H₂₀N₂O₂S₂

3-(4-Fluorophenyl)-2-(propylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one chemical structure, C15H15FN2OS2, CAS 687561-96-2

3-(4-Fluorophenyl)-2-(propylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one

CAS 687561-96-2C₁₅H₁₅FN₂OS₂

Ethyl 2-((3-(4-fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-2-methylpropanoate chemical structure, C18H19FN2O3S2, CAS 687562-50-1

Ethyl 2-((3-(4-fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-2-methylpropanoate

CAS 687562-50-1C₁₈H₁₉FN₂O₃S₂

2-((3-(4-Chlorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide chemical structure, C14H12ClN3O2S2, CAS 687563-96-8

2-((3-(4-Chlorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide

CAS 687563-96-8C₁₄H₁₂ClN₃O₂S₂

3-(4-Chlorophenyl)-2-propylsulfanyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-one chemical structure, C15H15ClN2OS2, CAS 687564-44-9

3-(4-Chlorophenyl)-2-propylsulfanyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-one

CAS 687564-44-9C₁₅H₁₅ClN₂OS₂

2-(Butylthio)-3-(4-chlorophenyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one chemical structure, C16H17ClN2OS2, CAS 687564-52-9

2-(Butylthio)-3-(4-chlorophenyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one

CAS 687564-52-9C₁₆H₁₇ClN₂OS₂

Ethyl 2-[[3-(4-chlorophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-2-methylpropanoate chemical structure, C18H19ClN2O3S2, CAS 687565-24-8

Ethyl 2-[[3-(4-chlorophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-2-methylpropanoate

CAS 687565-24-8C₁₈H₁₉ClN₂O₃S₂

3-(4-Bromophenyl)-2-ethylsulfanyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-one chemical structure, C14H13BrN2OS2, CAS 687566-54-7

3-(4-Bromophenyl)-2-ethylsulfanyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-one

CAS 687566-54-7C₁₄H₁₃BrN₂OS₂

3-(4-Bromophenyl)-2-(propylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one chemical structure, C15H15BrN2OS2, CAS 687566-59-2

3-(4-Bromophenyl)-2-(propylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one

CAS 687566-59-2C₁₅H₁₅BrN₂OS₂