Free for buyers, contact details stay privateFree for buyers. Your contact details stay private until you accept a quote.

Sign in Join free

Murcko scaffold

Ring system with 4 rings and 21 atoms

19 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 21
Chemicals: 19
With full pages: 7

Scaffold SMILES

O=C1c2n[nH]cc2C(c2ccccc2)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1c2n[nH]cc2C(c2ccccc2)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

Ethyl 4-(4-(4-hydroxyphenyl)-3-methyl-6-oxo-4,6-dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl)benzoate chemical structure, C21H19N3O4, CAS 573695-84-8

Ethyl 4-(4-(4-hydroxyphenyl)-3-methyl-6-oxo-4,6-dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl)benzoate

CAS 573695-84-8C₂₁H₁₉N₃O₄

4-(4-Hydroxy-3-methoxyphenyl)-3-methyl-5-(4-methylphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one chemical structure, C20H19N3O3, CAS 573942-06-0

4-(4-Hydroxy-3-methoxyphenyl)-3-methyl-5-(4-methylphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one

CAS 573942-06-0C₂₀H₁₉N₃O₃

Ethyl 4-(3-methyl-6-oxo-4-phenyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl)benzoate chemical structure, C21H19N3O3, CAS 573945-16-1

Ethyl 4-(3-methyl-6-oxo-4-phenyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl)benzoate

CAS 573945-16-1C₂₁H₁₉N₃O₃

5-(4-Bromophenyl)-4-(3-ethoxy-4-hydroxyphenyl)-3-methyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one chemical structure, C20H18BrN3O3, CAS 587010-15-9

5-(4-Bromophenyl)-4-(3-ethoxy-4-hydroxyphenyl)-3-methyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one

CAS 587010-15-9C₂₀H₁₈BrN₃O₃

4-(3-Ethoxy-4-hydroxyphenyl)-3-methyl-5-(4-methylphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one chemical structure, C21H21N3O3, CAS 587005-40-1

4-(3-Ethoxy-4-hydroxyphenyl)-3-methyl-5-(4-methylphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one

CAS 587005-40-1C₂₁H₂₁N₃O₃

Methyl 4-[3-methyl-5-(4-methylphenyl)-6-oxo-2,4-dihydropyrrolo[3,4-c]pyrazol-4-yl]benzoate chemical structure, C21H19N3O3, CAS 573705-93-8

Methyl 4-[3-methyl-5-(4-methylphenyl)-6-oxo-2,4-dihydropyrrolo[3,4-c]pyrazol-4-yl]benzoate

CAS 573705-93-8C₂₁H₁₉N₃O₃

5-(4-Bromophenyl)-3-methyl-4-(4-nitrophenyl)-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one chemical structure, C18H13BrN4O3, CAS 840513-10-2

5-(4-Bromophenyl)-3-methyl-4-(4-nitrophenyl)-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one

CAS 840513-10-2C₁₈H₁₃BrN₄O₃

3-Methyl-5-(4-methylphenyl)-4-(4-nitrophenyl)-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one chemical structure, C19H16N4O3, CAS 842958-41-2

3-Methyl-5-(4-methylphenyl)-4-(4-nitrophenyl)-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one

CAS 842958-41-2C₁₉H₁₆N₄O₃

4-(3-Fluorophenyl)-3-methyl-5-(4-methylphenyl)-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one chemical structure, C19H16FN3O, CAS 843630-58-0

4-(3-Fluorophenyl)-3-methyl-5-(4-methylphenyl)-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one

CAS 843630-58-0C₁₉H₁₆FN₃O

Ethyl 4-(4-(4-fluorophenyl)-3-methyl-6-oxo-4,6-dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl)benzoate chemical structure, C21H18FN3O3, CAS 587009-71-0

Ethyl 4-(4-(4-fluorophenyl)-3-methyl-6-oxo-4,6-dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl)benzoate

CAS 587009-71-0C₂₁H₁₈FN₃O₃

4-(2-Fluorophenyl)-3-methyl-5-(4-methylphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one chemical structure, C19H16FN3O, CAS 578756-07-7

4-(2-Fluorophenyl)-3-methyl-5-(4-methylphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one

CAS 578756-07-7C₁₉H₁₆FN₃O

4-(3,4-Dimethoxyphenyl)-3-methyl-5-(4-methylphenyl)-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one chemical structure, C21H21N3O3, CAS 577763-86-1

4-(3,4-Dimethoxyphenyl)-3-methyl-5-(4-methylphenyl)-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one

CAS 577763-86-1C₂₁H₂₁N₃O₃

3-Methyl-5-(4-methylphenyl)-4-(2-nitrophenyl)-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one chemical structure, C19H16N4O3, CAS 585559-78-0

3-Methyl-5-(4-methylphenyl)-4-(2-nitrophenyl)-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one

CAS 585559-78-0C₁₉H₁₆N₄O₃

Ethyl 4-(4-(3-methoxyphenyl)-3-methyl-6-oxo-4,6-dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl)benzoate chemical structure, C22H21N3O4, CAS 575460-14-9

Ethyl 4-(4-(3-methoxyphenyl)-3-methyl-6-oxo-4,6-dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl)benzoate

CAS 575460-14-9C₂₂H₂₁N₃O₄

Ethyl 4-[4-(2-fluorophenyl)-3-methyl-6-oxo-2,4-dihydropyrrolo[3,4-c]pyrazol-5-yl]benzoate chemical structure, C21H18FN3O3, CAS 696629-01-3

Ethyl 4-[4-(2-fluorophenyl)-3-methyl-6-oxo-2,4-dihydropyrrolo[3,4-c]pyrazol-5-yl]benzoate

CAS 696629-01-3C₂₁H₁₈FN₃O₃

Ethyl 4-[4-(3-fluorophenyl)-3-methyl-6-oxo-2,4-dihydropyrrolo[3,4-c]pyrazol-5-yl]benzoate chemical structure, C21H18FN3O3, CAS 578720-99-7

Ethyl 4-[4-(3-fluorophenyl)-3-methyl-6-oxo-2,4-dihydropyrrolo[3,4-c]pyrazol-5-yl]benzoate

CAS 578720-99-7C₂₁H₁₈FN₃O₃

3-Methyl-5-(4-methylphenyl)-4-(3-nitrophenyl)-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one chemical structure, C19H16N4O3, CAS 585556-95-2

3-Methyl-5-(4-methylphenyl)-4-(3-nitrophenyl)-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one

CAS 585556-95-2C₁₉H₁₆N₄O₃

Ethyl 4-[4-(2-methoxyphenyl)-3-methyl-6-oxo-2,4-dihydropyrrolo[3,4-c]pyrazol-5-yl]benzoate chemical structure, C22H21N3O4, CAS 841207-80-5

Ethyl 4-[4-(2-methoxyphenyl)-3-methyl-6-oxo-2,4-dihydropyrrolo[3,4-c]pyrazol-5-yl]benzoate

CAS 841207-80-5C₂₂H₂₁N₃O₄

4-(4-Hydroxyphenyl)-3-methyl-5-(4-methylphenyl)-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one chemical structure, C19H17N3O2, CAS 843628-83-1

4-(4-Hydroxyphenyl)-3-methyl-5-(4-methylphenyl)-2,4-dihydropyrrolo[3,4-c]pyrazol-6-one

CAS 843628-83-1C₁₉H₁₇N₃O₂