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Murcko scaffold

Ring system with 4 rings and 21 atoms

11 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
11
With full pages
3
Scaffold SMILES

O=C1C2CCCN2C(c2ccccc2)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C2CCCN2C(c2ccccc2)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

2-(4-Chlorophenyl)-3-(2,5-dimethoxyphenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one chemical structure, C20H21ClN2O3, CAS 1034845-99-2
2-(4-Chlorophenyl)-3-(2,5-dimethoxyphenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one
CAS 1034845-99-2C20H21ClN2O3
2-(3,4-Dichlorophenyl)-3-(3,4,5-trimethoxyphenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one chemical structure, C21H22Cl2N2O4, CAS 1035011-19-8
2-(3,4-Dichlorophenyl)-3-(3,4,5-trimethoxyphenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one
CAS 1035011-19-8C21H22Cl2N2O4
2-(4-Chlorophenyl)-3-(3,4,5-trimethoxyphenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one chemical structure, C21H23ClN2O4, CAS 1035301-26-8
2-(4-Chlorophenyl)-3-(3,4,5-trimethoxyphenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one
CAS 1035301-26-8C21H23ClN2O4
2-(4-Chlorophenyl)-3-(4-nitrophenyl)-hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one chemical structure, C18H16ClN3O3, CAS 1008571-67-2
2-(4-Chlorophenyl)-3-(4-nitrophenyl)-hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one
CAS 1008571-67-2C18H16ClN3O3
3-[4-(Dimethylamino)phenyl]-2-(4-methoxyphenyl)-hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one chemical structure, C21H25N3O2, CAS 1009605-56-4
3-[4-(Dimethylamino)phenyl]-2-(4-methoxyphenyl)-hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one
CAS 1009605-56-4C21H25N3O2
2-(3-Methoxyphenyl)-3-(p-tolyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one chemical structure, C20H22N2O2, CAS 1008571-62-7
2-(3-Methoxyphenyl)-3-(p-tolyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one
CAS 1008571-62-7C20H22N2O2
2-(4-Methoxyphenyl)-3-(4-nitrophenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one chemical structure, C19H19N3O4, CAS 1009178-25-9
2-(4-Methoxyphenyl)-3-(4-nitrophenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one
CAS 1009178-25-9C19H19N3O4
2-(3-Chlorophenyl)-3-(4-ethoxy-3-methoxyphenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one chemical structure, C21H23ClN2O3, CAS 1009516-49-7
2-(3-Chlorophenyl)-3-(4-ethoxy-3-methoxyphenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one
CAS 1009516-49-7C21H23ClN2O3
2-(3,4-Dichlorophenyl)-3-(p-tolyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one chemical structure, C19H18Cl2N2O, CAS 1094822-48-6
2-(3,4-Dichlorophenyl)-3-(p-tolyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one
CAS 1094822-48-6C19H18Cl2N2O
2-(3,4-Dichlorophenyl)-3-(4-(trifluoromethyl)phenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one chemical structure, C19H15Cl2F3N2O, CAS 1094784-45-8
2-(3,4-Dichlorophenyl)-3-(4-(trifluoromethyl)phenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one
CAS 1094784-45-8C19H15Cl2F3N2O
2,3-Bis(3,4-dichlorophenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one chemical structure, C18H14Cl4N2O, CAS 1101195-45-2
2,3-Bis(3,4-dichlorophenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one
CAS 1101195-45-2C18H14Cl4N2O