Murcko scaffold
Ring system with 2 rings and 16 atoms
36 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 16
- Chemicals
- 36
- With full pages
- 7
Scaffold SMILES
O=C(CSc1ccccc1)Nc1nncs1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 36 of 36 chemicals
![2-(Phenylsulfanyl)-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide chemical structure, C11H8F3N3OS2, CAS 309280-39-5](/s/AZUDTNUSWWODJN-UHFFFAOYSA-N.svg)
2-(Phenylsulfanyl)-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide
CAS 309280-39-5C11H8F3N3OS2
N-(5-Isopropyl-1,3,4-thiadiazol-2-yl)-2-(phenylthio)acetamide
CAS 309271-99-6C13H15N3OS2
![N-[5-(Methoxymethyl)-1,3,4-thiadiazol-2-yl]-2-phenylsulfanylacetamide chemical structure, C12H13N3O2S2, CAS 669704-88-5](/s/PCSNMNWDBCSFOX-UHFFFAOYSA-N.svg)
N-[5-(Methoxymethyl)-1,3,4-thiadiazol-2-yl]-2-phenylsulfanylacetamide
CAS 669704-88-5C12H13N3O2S2
N-(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)-2-phenylsulfanylacetamide
CAS 394233-07-9C12H13N3OS3
N-(5-Pentan-3-yl-1,3,4-thiadiazol-2-yl)-2-phenylsulfanylacetamide
CAS 600150-45-6C15H19N3OS2
N-(5-tert-Butyl-1,3,4-thiadiazol-2-yl)-2-phenylsulfanylacetamide
CAS 724734-78-5C14H17N3OS2
![2-(2-Amino-phenylsulfanyl)-N-(5-methyl-[1,3,4]thiadiazol-2-yl)-acetamide chemical structure, C11H12N4OS2, CAS 436094-55-2](/s/UPAVLRSPGGAWTR-UHFFFAOYSA-N.svg)
2-(2-Amino-phenylsulfanyl)-N-(5-methyl-[1,3,4]thiadiazol-2-yl)-acetamide
CAS 436094-55-2C11H12N4OS2
2-((4-Chlorophenyl)thio)-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide
CAS 313704-81-3C11H10ClN3OS2
![2-[(2-Aminophenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide chemical structure, C11H9F3N4OS2, CAS 478045-34-0](/s/FNBXLDWDJFHIQX-UHFFFAOYSA-N.svg)
2-[(2-Aminophenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide
CAS 478045-34-0C11H9F3N4OS2
![2-[(4-Bromophenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide chemical structure, C11H7BrF3N3OS2, CAS 339013-79-5](/s/BIWFZNSDSNKBKG-UHFFFAOYSA-N.svg)
2-[(4-Bromophenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide
CAS 339013-79-5C11H7BrF3N3OS2
![2-[(4-Chlorophenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide chemical structure, C11H7ClF3N3OS2, CAS 339013-81-9](/s/CBHGBDRCXZQNJP-UHFFFAOYSA-N.svg)
2-[(4-Chlorophenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide
CAS 339013-81-9C11H7ClF3N3OS2
![2-[(2-Chlorophenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide chemical structure, C11H7ClF3N3OS2, CAS 339013-82-0](/s/ROAKZZCAQBANET-UHFFFAOYSA-N.svg)
2-[(2-Chlorophenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide
CAS 339013-82-0C11H7ClF3N3OS2
![2-[(4-Methoxyphenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide chemical structure, C12H10F3N3O2S2, CAS 339013-83-1](/s/WVRLDFGGZLNYNP-UHFFFAOYSA-N.svg)
2-[(4-Methoxyphenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide
CAS 339013-83-1C12H10F3N3O2S2
![2-[(3-Chlorophenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide chemical structure, C11H7ClF3N3OS2, CAS 339013-85-3](/s/ZNETVWYSSWGGIT-UHFFFAOYSA-N.svg)
2-[(3-Chlorophenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide
CAS 339013-85-3C11H7ClF3N3OS2
![2-[(2,3-Dichlorophenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide chemical structure, C11H6Cl2F3N3OS2, CAS 339013-87-5](/s/TYDHEXZDXJGRFY-UHFFFAOYSA-N.svg)
2-[(2,3-Dichlorophenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide
CAS 339013-87-5C11H6Cl2F3N3OS2
![2-[(2-Methylphenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide chemical structure, C12H10F3N3OS2, CAS 339013-89-7](/s/MAAYNRJUPMVKOG-UHFFFAOYSA-N.svg)
2-[(2-Methylphenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide
CAS 339013-89-7C12H10F3N3OS2
![Methyl 2-[(2-oxo-2-{[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]amino}ethyl)sulfanyl]benzenecarboxylate chemical structure, C13H10F3N3O3S2, CAS 339013-90-0](/s/XHTAIZPLLMRKFM-UHFFFAOYSA-N.svg)
Methyl 2-[(2-oxo-2-{[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]amino}ethyl)sulfanyl]benzenecarboxylate
CAS 339013-90-0C13H10F3N3O3S2
![2-[(2,5-Dichlorophenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide chemical structure, C11H6Cl2F3N3OS2, CAS 339014-08-3](/s/CWQVXQLGDZBSMW-UHFFFAOYSA-N.svg)
2-[(2,5-Dichlorophenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide
CAS 339014-08-3C11H6Cl2F3N3OS2
![N-[5-(2-Methoxyethylsulfanyl)-1,3,4-thiadiazol-2-yl]-2-phenylsulfanylacetamide chemical structure, C13H15N3O2S3, CAS 710980-29-3](/s/AJDUTWPCOWTIAF-UHFFFAOYSA-N.svg)
N-[5-(2-Methoxyethylsulfanyl)-1,3,4-thiadiazol-2-yl]-2-phenylsulfanylacetamide
CAS 710980-29-3C13H15N3O2S3
![N-[5-(Ethoxymethyl)-1,3,4-thiadiazol-2-yl]-2-(phenylthio)acetamide chemical structure, C13H15N3O2S2, CAS 701221-90-1](/s/CEAQUIJPGSBKQW-UHFFFAOYSA-N.svg)
N-[5-(Ethoxymethyl)-1,3,4-thiadiazol-2-yl]-2-(phenylthio)acetamide
CAS 701221-90-1C13H15N3O2S2
2-((4-Chlorophenyl)thio)-N-(1,3,4-thiadiazol-2-yl)acetamide
CAS 331658-83-4C10H8ClN3OS2
![N-[5-(2-Methylpropyl)-1,3,4-thiadiazol-2-yl]-2-phenylsulfanylacetamide chemical structure, C14H17N3OS2, CAS 510737-29-8](/s/YJNCMDYHWDXQQB-UHFFFAOYSA-N.svg)
N-[5-(2-Methylpropyl)-1,3,4-thiadiazol-2-yl]-2-phenylsulfanylacetamide
CAS 510737-29-8C14H17N3OS2
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-(4-fluorophenyl)sulfanylacetamide
CAS 831207-27-3C12H12FN3OS2
2-(4-tert-Butylphenyl)sulfanyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide
CAS 824979-37-5C15H19N3OS2
- N-[5-(Ethylsulfanyl)-1,3,4-thiadiazol-2-yl]-2-(phenylsulfanyl)propanamide394236-07-8C13H15N3OS3
- 2-[(4-Methylphenyl)sulfanyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide338966-33-9C12H10F3N3OS2
- 2-((4-Chlorophenyl)thio)-N-(5-(ethylthio)-1,3,4-thiadiazol-2-yl)acetamide394233-09-1C12H12ClN3OS3
- N-(5-Methyl-1,3,4-thiadiazol-2-yl)-2-(p-tolylthio)butanamide394236-34-1C14H17N3OS2
- 2-((4-Chlorophenyl)thio)-N-(5-(ethylthio)-1,3,4-thiadiazol-2-yl)butanamide394239-09-9C14H16ClN3OS3
- 2-(4-Chlorophenyl)sulfanyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)butanamide394236-32-9C13H14ClN3OS2
- N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-phenylsulfanylpropanamide394233-57-9C13H15N3OS2
- N-(5-Methyl-1,3,4-thiadiazol-2-yl)-2-(phenylthio)propanamide394233-39-7C12H13N3OS2
- 2-((4-Chlorophenyl)thio)-N-(5-methyl-1,3,4-thiadiazol-2-yl)propanamide394233-41-1C12H12ClN3OS2
- 2-((4-Chlorophenyl)thio)-N-(5-isopropyl-1,3,4-thiadiazol-2-yl)propanamide394233-82-0C14H16ClN3OS2
- 2-[(4-Aminophenyl)thio]-N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]propanamide931292-83-0C13H16N4OS3
- 2-[(4-Fluorophenyl)sulfanyl]-N-(1,3,4-thiadiazol-2-yl)acetamide2324601-91-2C10H8FN3OS2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(CSc1nnc[nH]1)Nc1ccccc1](/scaffold/VJBDIQRNSVRUDP-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc[nH]1)Nc1ccccc165 chemicals
O=C(COc1ccccc1)Nc1nccs143 chemicals
O=C(CCc1ccco1)Nc1ccccc134 chemicals
O=C(CSc1nncs1)Nc1ccccc134 chemicals![Scaffold O=C(NN=Cc1ccccc1)c1cc[nH]n1](/scaffold/UEBQXDJERRSAMF-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1cc[nH]n129 chemicals
O=C(CCc1ccccc1)Nc1nncs125 chemicals
S=C(NCc1ccco1)Nc1ccccc124 chemicals![Scaffold O=C(CSc1nnn[nH]1)Nc1ccccc1](/scaffold/FDRBWKCIVMSABC-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnn[nH]1)Nc1ccccc122 chemicals![Scaffold O=C(CSc1ncc[nH]1)Nc1ccccc1](/scaffold/OMOYRSCPUXAYDW-UHFFFAOYSA-N/structure.svg)
O=C(CSc1ncc[nH]1)Nc1ccccc121 chemicals
O=C(NC(=S)Nc1ccccc1)c1ccco121 chemicals
O=C(CCN1CCCC1)Nc1ccccc120 chemicals
O=C(NN=Cc1ccco1)c1ccccc119 chemicals