Murcko scaffold
Ring system with 2 rings and 16 atoms
163 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 16
- Chemicals
- 163
- With full pages
- 29
Scaffold SMILES
O=C(NN=Cc1ccccc1)c1cc[nH]n1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=C(NN=Cc1ccccc1)c1cc[nH]n1](/scaffold/UEBQXDJERRSAMF-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 163 chemicals
![1-Methyl-1H-pyrazole-3-carboxylic acid 2-[(4-ethoxy-3-hydroxyphenyl)methylene]hydrazide chemical structure, C14H16N4O3, CAS 1006518-90-6](/s/FCGGVJVSSNDWAT-UHFFFAOYSA-N.svg)
1-Methyl-1H-pyrazole-3-carboxylic acid 2-[(4-ethoxy-3-hydroxyphenyl)methylene]hydrazide
CAS 1006518-90-6C14H16N4O3
![4-Bromo-N-[(3-hydroxyphenyl)methylideneamino]-1-methylpyrazole-3-carboxamide chemical structure, C12H11BrN4O2, CAS 725251-25-2](/s/BMYFZHOREUBRQT-UHFFFAOYSA-N.svg)
4-Bromo-N-[(3-hydroxyphenyl)methylideneamino]-1-methylpyrazole-3-carboxamide
CAS 725251-25-2C12H11BrN4O2
![N'-[1-(2-Hydroxyphenyl)ethylidene]-3-methyl-1H-pyrazole-5-carbohydrazide chemical structure, C13H14N4O2, CAS 944780-95-4](/s/YYGNLEAKGXYTOQ-UHFFFAOYSA-N.svg)
N'-[1-(2-Hydroxyphenyl)ethylidene]-3-methyl-1H-pyrazole-5-carbohydrazide
CAS 944780-95-4C13H14N4O2
![N-[(2,4-Dichlorophenyl)methylideneamino]-5-methyl-1H-pyrazole-3-carboxamide chemical structure, C12H10Cl2N4O, CAS 4834-07-5](/s/JXZKNSZCVBUKCK-UHFFFAOYSA-N.svg)
N-[(2,4-Dichlorophenyl)methylideneamino]-5-methyl-1H-pyrazole-3-carboxamide
CAS 4834-07-5C12H10Cl2N4O
![N'-{(Z)-[4-(Diethylamino)-2-hydroxyphenyl]methylidene}-3-methyl-1H-pyrazole-5-carbohydrazide chemical structure, C16H21N5O2, CAS 306755-70-4](/s/GDOZRPJUBBRPNX-UHFFFAOYSA-N.svg)
N'-{(Z)-[4-(Diethylamino)-2-hydroxyphenyl]methylidene}-3-methyl-1H-pyrazole-5-carbohydrazide
CAS 306755-70-4C16H21N5O2
![5-(1,1-Dimethylethyl)-1H-pyrazole-3-carboxylic acid 2-[(2-hydroxy-3-nitrophenyl)methylene]hydrazide chemical structure, C15H17N5O4, CAS 387344-76-5](/s/MHWUECCPBDWUFG-UHFFFAOYSA-N.svg)
5-(1,1-Dimethylethyl)-1H-pyrazole-3-carboxylic acid 2-[(2-hydroxy-3-nitrophenyl)methylene]hydrazide
CAS 387344-76-5C15H17N5O4
![5-(1,1-Dimethylethyl)-1H-pyrazole-3-carboxylic acid 2-[(5-bromo-2-hydroxy-3-nitrophenyl)methylene]hydrazide chemical structure, C15H16BrN5O4, CAS 402727-86-0](/s/GOMQHDOEFIFZKB-UHFFFAOYSA-N.svg)
5-(1,1-Dimethylethyl)-1H-pyrazole-3-carboxylic acid 2-[(5-bromo-2-hydroxy-3-nitrophenyl)methylene]hydrazide
CAS 402727-86-0C15H16BrN5O4
![N-[(E)-Benzylideneamino]-5-tert-butyl-1H-pyrazole-3-carboxamide chemical structure, C15H18N4O, CAS 402600-75-3](/s/YKNCHILAMPMLRP-MHWRWJLKSA-N.svg)
N-[(E)-Benzylideneamino]-5-tert-butyl-1H-pyrazole-3-carboxamide
CAS 402600-75-3C15H18N4O
(E)-N'-(3-Hydroxy-4-methoxybenzylidene)-3-methyl-1H-pyrazole-5-carbohydrazide
CAS 1284268-48-9C13H14N4O3
(E)-N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-methyl-1H-pyrazole-5-carbohydrazide
CAS 1285537-03-2C15H18N4O3
![N-[(E)-(2,5-Dimethoxyphenyl)methylideneamino]-1H-pyrazole-5-carboxamide chemical structure, C13H14N4O3, CAS 1321701-40-9](/s/UZDHPCXJVPHYIH-OVCLIPMQSA-N.svg)
N-[(E)-(2,5-Dimethoxyphenyl)methylideneamino]-1H-pyrazole-5-carboxamide
CAS 1321701-40-9C13H14N4O3
![2-Methyl-N-[(E)-(3-nitrophenyl)methylideneamino]pyrazole-3-carboxamide chemical structure, C12H11N5O3, CAS 300668-42-2](/s/ZRGKPSLJTDUUBX-MDWZMJQESA-N.svg)
2-Methyl-N-[(E)-(3-nitrophenyl)methylideneamino]pyrazole-3-carboxamide
CAS 300668-42-2C12H11N5O3
(E)-3-(tert-Butyl)-N'-(2-chlorobenzylidene)-1H-pyrazole-5-carbohydrazide
CAS 1048933-09-0C15H17ClN4O
![5-tert-Butyl-N-[(Z)-[4-(diethylamino)phenyl]methylideneamino]-1H-pyrazole-3-carboxamide chemical structure, C19H27N5O](/s/FFCZTVFCHSBPNQ-MOSHPQCFSA-N.svg)
5-tert-Butyl-N-[(Z)-[4-(diethylamino)phenyl]methylideneamino]-1H-pyrazole-3-carboxamide
C19H27N5O
(E)-N'-(2,6-Dichlorobenzylidene)-3-methyl-1H-pyrazole-5-carbohydrazide
CAS 89270-42-8C12H10Cl2N4O
![N-[(E)-(4-Bromophenyl)methylideneamino]-5-tert-butyl-1H-pyrazole-3-carboxamide chemical structure, C15H17BrN4O, CAS 1305337-97-6](/s/RIHFNTINAXGVFE-RQZCQDPDSA-N.svg)
N-[(E)-(4-Bromophenyl)methylideneamino]-5-tert-butyl-1H-pyrazole-3-carboxamide
CAS 1305337-97-6C15H17BrN4O
![3-tert-Butyl-N'-{(E)-[4-(dimethylamino)phenyl]methylidene}-1H-pyrazole-5-carbohydrazide chemical structure, C17H23N5O, CAS 1299371-20-2](/s/ZYDLDCUJAUITBK-WOJGMQOQSA-N.svg)
3-tert-Butyl-N'-{(E)-[4-(dimethylamino)phenyl]methylidene}-1H-pyrazole-5-carbohydrazide
CAS 1299371-20-2C17H23N5O
3-tert-Butyl-N'-(4-fluorobenzylidene)-1H-pyrazole-5-carbohydrazide
CAS 1310359-38-6C15H17FN4O
(E)-3-Methyl-N'-(1-(p-tolyl)ethylidene)-1H-pyrazole-5-carbohydrazide
CAS 1285531-12-5C14H16N4O
(E)-N'-(4-Ethoxybenzylidene)-3-methyl-1H-pyrazole-5-carbohydrazide
CAS 306301-39-3C14H16N4O2
![5-tert-Butyl-N-[(E)-(2,4-dichlorophenyl)methylideneamino]-1H-pyrazole-3-carboxamide chemical structure, C15H16Cl2N4O, CAS 384822-15-5](/s/JJVHPCZLNBBIGW-QGMBQPNBSA-N.svg)
5-tert-Butyl-N-[(E)-(2,4-dichlorophenyl)methylideneamino]-1H-pyrazole-3-carboxamide
CAS 384822-15-5C15H16Cl2N4O
(Z)-3-(tert-Butyl)-N'-(2-methoxybenzylidene)-1H-pyrazole-5-carbohydrazide
CAS 1285495-78-4C16H20N4O2
3-tert-Butyl-N'-(4-methoxybenzylidene)-1H-pyrazole-5-carbohydrazide
CAS 1284275-05-3C16H20N4O2
![3-tert-Butyl-N'-[(1E)-1-(3-nitrophenyl)ethylidene]-1H-pyrazole-5-carbohydrazide chemical structure, C16H19N5O3, CAS 5791-35-5](/s/WBACIZGBAUDFLU-LICLKQGHSA-N.svg)
3-tert-Butyl-N'-[(1E)-1-(3-nitrophenyl)ethylidene]-1H-pyrazole-5-carbohydrazide
CAS 5791-35-5C16H19N5O3
- 5-Methyl-N'-[(E)-(2,4,5-trimethoxyphenyl)methylidene]-1H-pyrazole-3-carbohydrazide5791-69-5C15H18N4O4
- (E)-N'-(3-Methoxybenzylidene)-3-methyl-1H-pyrazole-5-carbohydrazide306301-35-9C13H14N4O2
- (Z)-3-(tert-Butyl)-N'-(4-chlorobenzylidene)-1H-pyrazole-5-carbohydrazide305354-79-4C15H17ClN4O
- N'-[(1E)-1-(4-Chlorophenyl)ethylidene]-3-methyl-1H-pyrazole-5-carbohydrazide1285497-63-3C13H13ClN4O
- (Z)-3-Isopropyl-N'-(3-methoxybenzylidene)-1H-pyrazole-5-carbohydrazide1285535-72-9C15H18N4O2
- (Z)-3-(tert-Butyl)-N'-(4-methylbenzylidene)-1H-pyrazole-5-carbohydrazide1284273-95-5C16H20N4O
- 3-Methyl-N'-[(1E)-1-(4-nitrophenyl)ethylidene]-1H-pyrazole-5-carbohydrazide1285537-54-3C13H13N5O3
- 3-Isopropyl-N'-(1-phenylethylidene)-1H-pyrazole-5-carbohydrazide303104-18-9C15H18N4O
- (E)-N'-(1-(2-Chlorophenyl)ethylidene)-3-isopropyl-1H-pyrazole-5-carbohydrazide1285530-99-5C15H17ClN4O
- (Z)-3-(tert-Butyl)-N'-(3,4-dimethoxybenzylidene)-1H-pyrazole-5-carbohydrazide1285537-48-5C17H22N4O3
- 4-Bromo-2,5-dimethyl-N-[(E)-1-[4-(propanoylamino)phenyl]ethylideneamino]pyrazole-3-carboxamide490032-61-6C17H20BrN5O2
- N-[(E)-1-(4-Acetamidophenyl)ethylideneamino]-4-iodo-1-methylpyrazole-3-carboxamide515122-51-7C15H16IN5O2
- N-[(E)-(3,4-Dimethoxyphenyl)methylideneamino]-1H-pyrazole-5-carboxamide300668-49-9C13H14N4O3
- 3-tert-Butyl-N'-{(E)-[4-(diethylamino)phenyl]methylidene}-1H-pyrazole-5-carbohydrazide305354-03-4C19H27N5O
- 3-tert-Butyl-N'-[(E)-(2-methoxyphenyl)methylidene]-1H-pyrazole-5-carbohydrazideC16H20N4O2
- 5-tert-Butyl-N-[(E)-(3,4,5-trimethoxyphenyl)methylideneamino]-1H-pyrazole-3-carboxamide1299390-44-5C18H24N4O4
- N'-[(1E)-1-(4-Aminophenyl)ethylidene]-5-(propan-2-yl)-1H-pyrazole-3-carbohydrazide1285683-83-1C15H19N5O
- (Z)-N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-isopropyl-1H-pyrazole-5-carbohydrazide1285532-29-7C17H22N4O3
- 4-Chloro-1-methyl-N'-(4-methylbenzylidene)-1H-pyrazole-3-carbohydrazide351334-05-9C13H13ClN4O
- (Z)-N'-(1-(4-Chlorophenyl)ethylidene)-3-isopropyl-1H-pyrazole-5-carbohydrazide403659-98-3C15H17ClN4O
- (Z)-N'-(1-(4-Bromophenyl)ethylidene)-3-isopropyl-1H-pyrazole-5-carbohydrazide403659-99-4C15H17BrN4O
- N'-[(1Z)-1-(3-Hydroxyphenyl)ethylidene]-3-methyl-1H-pyrazole-5-carbohydrazide634882-74-9C13H14N4O2
- (E)-3-Isopropyl-N'-(3,4,5-trimethoxybenzylidene)-1H-pyrazole-5-carbohydrazide403659-67-6C17H22N4O4
- (E)-Methyl 4-((2-(3-isopropyl-1H-pyrazole-5-carbonyl)hydrazono)methyl)benzoate1310341-71-9C16H18N4O3
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(CSc1nnc[nH]1)Nc1ccccc1](/scaffold/VJBDIQRNSVRUDP-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc[nH]1)Nc1ccccc165 chemicals
O=C(COc1ccccc1)Nc1nccs143 chemicals
O=C(CCc1ccco1)Nc1ccccc134 chemicals
O=C(CSc1nncs1)Nc1ccccc134 chemicals
O=C(CCc1ccccc1)Nc1nncs125 chemicals
S=C(NCc1ccco1)Nc1ccccc124 chemicals![Scaffold O=C(CSc1nnn[nH]1)Nc1ccccc1](/scaffold/FDRBWKCIVMSABC-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnn[nH]1)Nc1ccccc122 chemicals![Scaffold O=C(CSc1ncc[nH]1)Nc1ccccc1](/scaffold/OMOYRSCPUXAYDW-UHFFFAOYSA-N/structure.svg)
O=C(CSc1ncc[nH]1)Nc1ccccc121 chemicals
O=C(NC(=S)Nc1ccccc1)c1ccco121 chemicals
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