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Murcko scaffold

Ring system with 2 rings and 16 atoms

324 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
324
With full pages
34
Scaffold SMILES

O=C(CSc1nncs1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nncs1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 324 chemicals

N-(2-Ethoxyphenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide chemical structure, C13H15N3O2S2, CAS 346639-10-9
N-(2-Ethoxyphenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
CAS 346639-10-9C13H15N3O2S2
N-(2,4-Dimethoxyphenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide chemical structure, C13H15N3O3S2, CAS 354538-76-4
N-(2,4-Dimethoxyphenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
CAS 354538-76-4C13H15N3O3S2
N-[4-[Chloro(difluoro)methoxy]phenyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide chemical structure, C12H10ClF2N3O2S2, CAS 442638-93-9
N-[4-[Chloro(difluoro)methoxy]phenyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
CAS 442638-93-9C12H10ClF2N3O2S2
N-(3-Chloro-4-fluorophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide chemical structure, C11H9ClFN3OS2, CAS 329079-08-5
N-(3-Chloro-4-fluorophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
CAS 329079-08-5C11H9ClFN3OS2
2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C11H9F3N4OS2, CAS 271798-74-4
2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 271798-74-4C11H9F3N4OS2
Butyl 4-[[2-[(5-amino-1,3,4-thiadiazol-2-yl)thio]acetyl]amino]benzoate chemical structure, C15H18N4O3S2, CAS 329921-14-4
Butyl 4-[[2-[(5-amino-1,3,4-thiadiazol-2-yl)thio]acetyl]amino]benzoate
CAS 329921-14-4C15H18N4O3S2
2-[(5-Amino-1,3,4-thiadiazol-2-yl)thio]-N-(5-chloro-2-methylphenyl)acetamide chemical structure, C11H11ClN4OS2, CAS 328281-60-3
2-[(5-Amino-1,3,4-thiadiazol-2-yl)thio]-N-(5-chloro-2-methylphenyl)acetamide
CAS 328281-60-3C11H11ClN4OS2
2-[(5-Amino-1,3,4-thiadiazol-2-yl)thio]-N-(3-nitrophenyl)acetamide chemical structure, C10H9N5O3S2, CAS 339318-48-8
2-[(5-Amino-1,3,4-thiadiazol-2-yl)thio]-N-(3-nitrophenyl)acetamide
CAS 339318-48-8C10H9N5O3S2
N-(4-Ethoxyphenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide chemical structure, C14H17N3O2S2, CAS 346642-03-3
N-(4-Ethoxyphenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
CAS 346642-03-3C14H17N3O2S2
N-(5-((2-((4-Fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)propionamide chemical structure, C13H13FN4O2S2, CAS 392297-33-5
N-(5-((2-((4-Fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)propionamide
CAS 392297-33-5C13H13FN4O2S2
N-(4-Ethoxyphenyl)-2-((5-methyl-1,3,4-thiadiazol-2-yl)thio)acetamide chemical structure, C13H15N3O2S2, CAS 303090-82-6
N-(4-Ethoxyphenyl)-2-((5-methyl-1,3,4-thiadiazol-2-yl)thio)acetamide
CAS 303090-82-6C13H15N3O2S2
N-(3,5-Dimethylphenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide chemical structure, C13H15N3OS2, CAS 329079-42-7
N-(3,5-Dimethylphenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
CAS 329079-42-7C13H15N3OS2
N-(4-Fluorophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide chemical structure, C11H10FN3OS2, CAS 329079-49-4
N-(4-Fluorophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
CAS 329079-49-4C11H10FN3OS2
N-(2,4-Difluorophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide chemical structure, C11H9F2N3OS2, CAS 329079-52-9
N-(2,4-Difluorophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
CAS 329079-52-9C11H9F2N3OS2
N-(4-Methoxyphenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide chemical structure, C12H13N3O2S2, CAS 329079-69-8
N-(4-Methoxyphenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
CAS 329079-69-8C12H13N3O2S2
2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(2,4-dimethylphenyl)acetamide chemical structure, C12H14N4OS2, CAS 304662-72-4
2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(2,4-dimethylphenyl)acetamide
CAS 304662-72-4C12H14N4OS2
2-((5-Amino-1,3,4-thiadiazol-2-yl)thio)-N-(4-fluorophenyl)acetamide chemical structure, C10H9FN4OS2, CAS 292057-71-7
2-((5-Amino-1,3,4-thiadiazol-2-yl)thio)-N-(4-fluorophenyl)acetamide
CAS 292057-71-7C10H9FN4OS2
2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(4-bromophenyl)acetamide chemical structure, C10H9BrN4OS2, CAS 329921-68-8
2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(4-bromophenyl)acetamide
CAS 329921-68-8C10H9BrN4OS2
N-(3,5-Dichlorophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide chemical structure, C11H9Cl2N3OS2, CAS 306730-38-1
N-(3,5-Dichlorophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
CAS 306730-38-1C11H9Cl2N3OS2
N-(3-Chlorophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide chemical structure, C11H10ClN3OS2, CAS 298215-36-8
N-(3-Chlorophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
CAS 298215-36-8C11H10ClN3OS2
2-[(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(4-propan-2-ylphenyl)acetamide chemical structure, C14H17N3OS2, CAS 311315-74-9
2-[(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(4-propan-2-ylphenyl)acetamide
CAS 311315-74-9C14H17N3OS2
2-[(5-Amino-1,3,4-thiadiazol-2-yl)thio]-N-(4-methylphenyl)acetamide chemical structure, C11H12N4OS2, CAS 304662-71-3
2-[(5-Amino-1,3,4-thiadiazol-2-yl)thio]-N-(4-methylphenyl)acetamide
CAS 304662-71-3C11H12N4OS2
2-((5-Amino-1,3,4-thiadiazol-2-yl)thio)-N-(2-fluorophenyl)acetamide chemical structure, C10H9FN4OS2, CAS 329694-46-4
2-((5-Amino-1,3,4-thiadiazol-2-yl)thio)-N-(2-fluorophenyl)acetamide
CAS 329694-46-4C10H9FN4OS2
2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-phenylacetamide chemical structure, C10H10N4OS2, CAS 332114-16-6
2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-phenylacetamide
CAS 332114-16-6C10H10N4OS2