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Murcko scaffold

Ring system with 3 rings and 16 atoms

65 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
65
With full pages
3
Scaffold SMILES

O=C1C(=Cc2cccs2)Oc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=Cc2cccs2)Oc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 65 chemicals

(Z)-2-((3-Methylthiophen-2-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl dimethylcarbamate chemical structure, C17H15NO4S, CAS 622794-28-9
(Z)-2-((3-Methylthiophen-2-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl dimethylcarbamate
CAS 622794-28-9C17H15NO4S
(Z)-2-((3-Methylthiophen-2-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl acetate chemical structure, C16H12O4S, CAS 622358-63-8
(Z)-2-((3-Methylthiophen-2-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl acetate
CAS 622358-63-8C16H12O4S
(Z)-6-Methoxy-2-((3-methylthiophen-2-yl)methylene)benzofuran-3(2H)-one chemical structure, C15H12O3S, CAS 1164536-84-8
(Z)-6-Methoxy-2-((3-methylthiophen-2-yl)methylene)benzofuran-3(2H)-one
CAS 1164536-84-8C15H12O3S
(2Z)-6-Hydroxy-2-(2-thienylmethylene)-1-benzofuran-3(2H)-one chemical structure, C13H8O3S, CAS 637753-83-4
(2Z)-6-Hydroxy-2-(2-thienylmethylene)-1-benzofuran-3(2H)-one
CAS 637753-83-4C13H8O3S
(2Z)-6-Hydroxy-2-[(3-methyl-2-thienyl)methylene]-1-benzofuran-3(2H)-one chemical structure, C14H10O3S, CAS 620546-02-3
(2Z)-6-Hydroxy-2-[(3-methyl-2-thienyl)methylene]-1-benzofuran-3(2H)-one
CAS 620546-02-3C14H10O3S
3(2H)-Benzofuranone, 6-methoxy-2-(2-thienylmethylene)- chemical structure, C14H10O3S
3(2H)-Benzofuranone, 6-methoxy-2-(2-thienylmethylene)-
C14H10O3S
(Z)-2-((3-Methylthiophen-2-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl isobutyrate chemical structure, C18H16O4S, CAS 622359-91-5
(Z)-2-((3-Methylthiophen-2-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl isobutyrate
CAS 622359-91-5C18H16O4S
(Z)-2-((3-Methylthiophen-2-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl pivalate chemical structure, C19H18O4S, CAS 622360-61-6
(Z)-2-((3-Methylthiophen-2-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl pivalate
CAS 622360-61-6C19H18O4S
(Z)-6-((3-Methylbut-2-en-1-yl)oxy)-2-((3-methylthiophen-2-yl)methylene)benzofuran-3(2H)-one chemical structure, C19H18O3S, CAS 622808-59-7
(Z)-6-((3-Methylbut-2-en-1-yl)oxy)-2-((3-methylthiophen-2-yl)methylene)benzofuran-3(2H)-one
CAS 622808-59-7C19H18O3S
(Z)-6-((2-Methylallyl)oxy)-2-((3-methylthiophen-2-yl)methylene)benzofuran-3(2H)-one chemical structure, C18H16O3S, CAS 620547-43-5
(Z)-6-((2-Methylallyl)oxy)-2-((3-methylthiophen-2-yl)methylene)benzofuran-3(2H)-one
CAS 620547-43-5C18H16O3S
(Z)-Methyl 2-((2-((3-methylthiophen-2-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl)oxy)acetate chemical structure, C17H14O5S, CAS 620547-67-3
(Z)-Methyl 2-((2-((3-methylthiophen-2-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl)oxy)acetate
CAS 620547-67-3C17H14O5S
(Z)-7-((Diethylamino)methyl)-6-hydroxy-2-(thiophen-2-ylmethylene)benzofuran-3(2H)-one chemical structure, C18H19NO3S, CAS 896808-10-9
(Z)-7-((Diethylamino)methyl)-6-hydroxy-2-(thiophen-2-ylmethylene)benzofuran-3(2H)-one
CAS 896808-10-9C18H19NO3S
(Z)-2-((3-Methylthiophen-2-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl diethylcarbamate chemical structure, C19H19NO4S, CAS 622797-57-3
(Z)-2-((3-Methylthiophen-2-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl diethylcarbamate
CAS 622797-57-3C19H19NO4S
(Z)-7-((Diethylamino)methyl)-6-hydroxy-2-((3-methylthiophen-2-yl)methylene)benzofuran-3(2H)-one chemical structure, C19H21NO3S, CAS 896835-71-5
(Z)-7-((Diethylamino)methyl)-6-hydroxy-2-((3-methylthiophen-2-yl)methylene)benzofuran-3(2H)-one
CAS 896835-71-5C19H21NO3S
2-[[(2Z)-3-Oxo-2-(thiophen-2-ylmethylidene)-1-benzofuran-6-yl]oxy]acetic acid chemical structure, C15H10O5S, CAS 885952-31-8
2-[[(2Z)-3-Oxo-2-(thiophen-2-ylmethylidene)-1-benzofuran-6-yl]oxy]acetic acid
CAS 885952-31-8C15H10O5S
(Z)-7-((Dimethylamino)methyl)-6-hydroxy-2-(thiophen-2-ylmethylene)benzofuran-3(2H)-one chemical structure, C16H15NO3S, CAS 900298-32-0
(Z)-7-((Dimethylamino)methyl)-6-hydroxy-2-(thiophen-2-ylmethylene)benzofuran-3(2H)-one
CAS 900298-32-0C16H15NO3S
(Z)-7-((Bis(2-methoxyethyl)amino)methyl)-6-hydroxy-2-(thiophen-2-ylmethylene)benzofuran-3(2H)-one chemical structure, C20H23NO5S, CAS 900285-73-6
(Z)-7-((Bis(2-methoxyethyl)amino)methyl)-6-hydroxy-2-(thiophen-2-ylmethylene)benzofuran-3(2H)-one
CAS 900285-73-6C20H23NO5S
(Z)-Isopropyl 2-((2-((3-methylthiophen-2-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl)oxy)acetate chemical structure, C19H18O5S, CAS 622806-88-6
(Z)-Isopropyl 2-((2-((3-methylthiophen-2-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl)oxy)acetate
CAS 622806-88-6C19H18O5S
6-Methoxy-2-(thiophen-2-ylmethylene)benzofuran-3(2H)-one chemical structure, C14H10O3S
6-Methoxy-2-(thiophen-2-ylmethylene)benzofuran-3(2H)-one
C14H10O3S
(Z)-6-Methoxy-2-(thiophen-2-ylmethylene)benzofuran-3(2H)-one chemical structure, C14H10O3S, CAS 646996-28-3
(Z)-6-Methoxy-2-(thiophen-2-ylmethylene)benzofuran-3(2H)-one
CAS 646996-28-3C14H10O3S
(2Z)-2-[(3-Methylthiophen-2-yl)methylidene]-3-oxo-2,3-dihydro-1-benzofuran-6-yl propanoate chemical structure, C17H14O4S, CAS 622359-25-5
(2Z)-2-[(3-Methylthiophen-2-yl)methylidene]-3-oxo-2,3-dihydro-1-benzofuran-6-yl propanoate
CAS 622359-25-5C17H14O4S
(Z)-2-((3-Oxo-2-(thiophen-2-ylmethylene)-2,3-dihydrobenzofuran-6-yl)oxy)acetonitrile chemical structure, C15H9NO3S, CAS 844850-99-3
(Z)-2-((3-Oxo-2-(thiophen-2-ylmethylene)-2,3-dihydrobenzofuran-6-yl)oxy)acetonitrile
CAS 844850-99-3C15H9NO3S
(Z)-Allyl 2-((2-((3-methylthiophen-2-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl)oxy)acetate chemical structure, C19H16O5S, CAS 622815-09-2
(Z)-Allyl 2-((2-((3-methylthiophen-2-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl)oxy)acetate
CAS 622815-09-2C19H16O5S
(Z)-6-Ethoxy-2-((3-methylthiophen-2-yl)methylene)benzofuran-3(2H)-one chemical structure, C16H14O3S, CAS 620547-19-5
(Z)-6-Ethoxy-2-((3-methylthiophen-2-yl)methylene)benzofuran-3(2H)-one
CAS 620547-19-5C16H14O3S