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Murcko scaffold

1-(1H-Pyrazol-3-yl)pyrrolidin-2-one scaffold

25 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
25
With full pages
4
Scaffold SMILES

O=C1CCCN1c1cc[nH]n1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(1H-Pyrazol-3-yl)pyrrolidin-2-one page
Murcko scaffold O=C1CCCN1c1cc[nH]n1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

1-(5-tert-Butyl-1H-pyrazol-3-yl)-5-hydroxy-3-methylpyrrolidin-2-one chemical structure, C12H19N3O2, CAS 127056-80-8
1-(5-tert-Butyl-1H-pyrazol-3-yl)-5-hydroxy-3-methylpyrrolidin-2-one
CAS 127056-80-8C12H19N3O2
1-(1-Ethyl-5-methyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxylic acid chemical structure, C11H15N3O3, CAS 925199-99-1
1-(1-Ethyl-5-methyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxylic acid
CAS 925199-99-1C11H15N3O3
1-(1H-Pyrazol-3-yl)pyrrolidin-2-one chemical structure, C7H9N3O, CAS 786700-16-1
1-(1H-Pyrazol-3-yl)pyrrolidin-2-one
CAS 786700-16-1C7H9N3O
1-(5-Methyl-1-propyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxylic acid chemical structure, C12H17N3O3, CAS 1172320-01-2
1-(5-Methyl-1-propyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxylic acid
CAS 1172320-01-2C12H17N3O3
5-Oxo-1-(1H-pyrazol-3-yl)pyrrolidine-3-carboxylic acid chemical structure, C8H9N3O3, CAS 1171036-90-0
5-Oxo-1-(1H-pyrazol-3-yl)pyrrolidine-3-carboxylic acid
CAS 1171036-90-0C8H9N3O3
1-(1-Methyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxylic acid chemical structure, C9H11N3O3, CAS 1171097-21-4
1-(1-Methyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxylic acid
CAS 1171097-21-4C9H11N3O3
1-(1-Methyl-1H-pyrazol-3-yl)pyrrolidin-2-one chemical structure, C8H11N3O, CAS 1189655-98-8
1-(1-Methyl-1H-pyrazol-3-yl)pyrrolidin-2-one
CAS 1189655-98-8C8H11N3O
3-Bromo-1-(1-methyl-1H-pyrazol-3-yl)pyrrolidin-2-one chemical structure, C8H10BrN3O, CAS 1315367-41-9
3-Bromo-1-(1-methyl-1H-pyrazol-3-yl)pyrrolidin-2-one
CAS 1315367-41-9C8H10BrN3O
3-Amino-1-(1-methyl-1H-pyrazol-3-yl)pyrrolidin-2-one chemical structure, C8H12N4O, CAS 1315365-07-1
3-Amino-1-(1-methyl-1H-pyrazol-3-yl)pyrrolidin-2-one
CAS 1315365-07-1C8H12N4O
3-Amino-1-(1,3-dimethyl-1H-pyrazol-5-yl)pyrrolidin-2-one chemical structure, C9H14N4O, CAS 1354950-92-7
3-Amino-1-(1,3-dimethyl-1H-pyrazol-5-yl)pyrrolidin-2-one
CAS 1354950-92-7C9H14N4O
3-Bromo-1-(1,3-dimethyl-1H-pyrazol-5-yl)pyrrolidin-2-one chemical structure, C9H12BrN3O, CAS 1354952-65-0
3-Bromo-1-(1,3-dimethyl-1H-pyrazol-5-yl)pyrrolidin-2-one
CAS 1354952-65-0C9H12BrN3O
1-(4-Amino-1-methyl-1H-pyrazol-3-yl)-3,3-dimethyl-2-pyrrolidinone chemical structure, C10H16N4O, CAS 1773505-43-3
1-(4-Amino-1-methyl-1H-pyrazol-3-yl)-3,3-dimethyl-2-pyrrolidinone
CAS 1773505-43-3C10H16N4O
1-(4-Bromo-1-methyl-1H-pyrazol-3-yl)-2-pyrrolidinone chemical structure, C8H10BrN3O, CAS 1773505-13-7
1-(4-Bromo-1-methyl-1H-pyrazol-3-yl)-2-pyrrolidinone
CAS 1773505-13-7C8H10BrN3O
3-Methyl-1-(1-methyl-1H-pyrazol-3-yl)-2-pyrrolidinone chemical structure, C9H13N3O, CAS 1773504-59-8
3-Methyl-1-(1-methyl-1H-pyrazol-3-yl)-2-pyrrolidinone
CAS 1773504-59-8C9H13N3O
1-(1-Methyl-1H-pyrazol-3-yl)-2-oxopyrrolidine-3-carbonitrile chemical structure, C9H10N4O, CAS 1773505-26-2
1-(1-Methyl-1H-pyrazol-3-yl)-2-oxopyrrolidine-3-carbonitrile
CAS 1773505-26-2C9H10N4O
3,3-Dimethyl-1-(1-methyl-1H-pyrazol-3-yl)-2-pyrrolidinone chemical structure, C10H15N3O, CAS 1773505-39-7
3,3-Dimethyl-1-(1-methyl-1H-pyrazol-3-yl)-2-pyrrolidinone
CAS 1773505-39-7C10H15N3O
3-Methyl-1-(1-methyl-4-nitro-1H-pyrazol-3-yl)-2-pyrrolidinone chemical structure, C9H12N4O3, CAS 1773504-62-3
3-Methyl-1-(1-methyl-4-nitro-1H-pyrazol-3-yl)-2-pyrrolidinone
CAS 1773504-62-3C9H12N4O3
1-(4-Bromo-1-methyl-1H-pyrazol-3-yl)-4-(hydroxymethyl)pyrrolidin-2-one chemical structure, C9H12BrN3O2, CAS 1773505-22-8
1-(4-Bromo-1-methyl-1H-pyrazol-3-yl)-4-(hydroxymethyl)pyrrolidin-2-one
CAS 1773505-22-8C9H12BrN3O2
1-(4-Bromo-1-methyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxylic acid chemical structure, C9H10BrN3O3, CAS 1773505-20-6
1-(4-Bromo-1-methyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxylic acid
CAS 1773505-20-6C9H10BrN3O3
3-Amino-1-(1H-pyrazol-3-yl)pyrrolidin-2-one chemical structure, C7H10N4O, CAS 1506420-65-0
3-Amino-1-(1H-pyrazol-3-yl)pyrrolidin-2-one
CAS 1506420-65-0C7H10N4O
1-(4-Bromo-1-methyl-1H-pyrazol-3-yl)-4-(((tert-butyl(dimethyl)silyl)oxy)methyl)pyrrolidin-2-one chemical structure, C15H26BrN3O2Si, CAS 1773505-24-0
1-(4-Bromo-1-methyl-1H-pyrazol-3-yl)-4-(((tert-butyl(dimethyl)silyl)oxy)methyl)pyrrolidin-2-one
CAS 1773505-24-0C15H26BrN3O2Si
N-[1-(1-Methylpyrazol-3-yl)-2-oxopyrrolidin-3-yl]prop-2-enamide chemical structure, C11H14N4O2, CAS 2174410-86-5
N-[1-(1-Methylpyrazol-3-yl)-2-oxopyrrolidin-3-yl]prop-2-enamide
CAS 2174410-86-5C11H14N4O2
N-[1-(2,5-Dimethylpyrazol-3-yl)-2-oxopyrrolidin-3-yl]prop-2-enamide chemical structure, C12H16N4O2, CAS 2174410-87-6
N-[1-(2,5-Dimethylpyrazol-3-yl)-2-oxopyrrolidin-3-yl]prop-2-enamide
CAS 2174410-87-6C12H16N4O2
3-Amino-1-(1H-pyrazol-3-yl)pyrrolidin-2-one dihydrochloride chemical structure, C7H12Cl2N4O, CAS 2411193-27-4
3-Amino-1-(1H-pyrazol-3-yl)pyrrolidin-2-one dihydrochloride
CAS 2411193-27-4C7H12Cl2N4O