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Murcko scaffold

5,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-one scaffold

79 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
79
With full pages
8
Scaffold SMILES

O=c1ccc2c([nH]1)CCNC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 5,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-one page
Murcko scaffold O=c1ccc2c([nH]1)CCNC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 79 chemicals

Ethyl 2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carboxylate chemical structure, C11H14N2O3, CAS 156364-00-0
Ethyl 2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carboxylate
CAS 156364-00-0C11H14N2O3
6-Methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one chemical structure, C9H12N2O, CAS 14757-35-8
6-Methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one
CAS 14757-35-8C9H12N2O
5,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-one chemical structure, C8H10N2O, CAS 676994-64-2
5,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-one
CAS 676994-64-2C8H10N2O
tert-Butyl 3-cyano-2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-6-carboxylate chemical structure, C14H17N3O3, CAS 1190440-61-9
tert-Butyl 3-cyano-2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-6-carboxylate
CAS 1190440-61-9C14H17N3O3
2-Hydroxy-5,6,7,8-tetrahydro-[1,6]naphthyridine-3-carboxylic acid methyl ester chemical structure, C10H12N2O3, CAS 933722-83-9
2-Hydroxy-5,6,7,8-tetrahydro-[1,6]naphthyridine-3-carboxylic acid methyl ester
CAS 933722-83-9C10H12N2O3
tert-Butyl 3-methanesulfonyl-2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-6-carboxylate chemical structure, C14H20N2O5S, CAS 1333763-64-6
tert-Butyl 3-methanesulfonyl-2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-6-carboxylate
CAS 1333763-64-6C14H20N2O5S
2-Oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carbonitrile chemical structure, C9H9N3O, CAS 1190440-62-0
2-Oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carbonitrile
CAS 1190440-62-0C9H9N3O
6-Methyl-2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carbonitrile chemical structure, C10H11N3O, CAS 14757-34-7
6-Methyl-2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carbonitrile
CAS 14757-34-7C10H11N3O
tert-Butyl 3-bromo-2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-6-carboxylate chemical structure, C13H17BrN2O3, CAS 1036381-92-6
tert-Butyl 3-bromo-2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-6-carboxylate
CAS 1036381-92-6C13H17BrN2O3
tert-Butyl 2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5H)-carboxylate chemical structure, C13H18N2O3, CAS 1036381-91-5
tert-Butyl 2-oxo-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5H)-carboxylate
CAS 1036381-91-5C13H18N2O3
3-(Aminomethyl)-6-methyl-1,2,5,6,7,8-hexahydro-1,6-naphthyridin-2-one chemical structure, C10H15N3O, CAS 933713-78-1
3-(Aminomethyl)-6-methyl-1,2,5,6,7,8-hexahydro-1,6-naphthyridin-2-one
CAS 933713-78-1C10H15N3O
6-Ethyl-2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carboxylic acid chemical structure, C11H14N2O3, CAS 1248066-20-7
6-Ethyl-2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carboxylic acid
CAS 1248066-20-7C11H14N2O3
6-Isopropyl-2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carboxylic acid chemical structure, C12H16N2O3, CAS 1281483-77-9
6-Isopropyl-2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carboxylic acid
CAS 1281483-77-9C12H16N2O3
6-Methyl-2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carboxylic acid chemical structure, C10H12N2O3, CAS 14903-72-1
6-Methyl-2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carboxylic acid
CAS 14903-72-1C10H12N2O3
6-[(tert-Butoxy)carbonyl]-2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carboxylic acid chemical structure, C14H18N2O5, CAS 1305278-26-5
6-[(tert-Butoxy)carbonyl]-2-oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carboxylic acid
CAS 1305278-26-5C14H18N2O5
1,2,5,6,7,8-Hexahydro-1,6-naphthyridin-2-one hydrochloride chemical structure, C8H11ClN2O, CAS 1211505-91-7
1,2,5,6,7,8-Hexahydro-1,6-naphthyridin-2-one hydrochloride
CAS 1211505-91-7C8H11ClN2O
tert-Butyl 8-methyl-2-oxo-1,5,7,8-tetrahydro-1,6-naphthyridine-6(2H)-carboxylate chemical structure, C14H20N2O3, CAS 1401034-50-1
tert-Butyl 8-methyl-2-oxo-1,5,7,8-tetrahydro-1,6-naphthyridine-6(2H)-carboxylate
CAS 1401034-50-1C14H20N2O3
8,8-Dimethyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one chemical structure, C10H14N2O, CAS 1151665-35-8
8,8-Dimethyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one
CAS 1151665-35-8C10H14N2O
6-Acetyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one chemical structure, C10H12N2O2, CAS 1421501-36-1
6-Acetyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one
CAS 1421501-36-1C10H12N2O2
6-(2-Ethoxyacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one chemical structure, C12H16N2O3, CAS 1421501-41-8
6-(2-Ethoxyacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one
CAS 1421501-41-8C12H16N2O3
2-Oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carbonitrile hydrochloride chemical structure, C9H10ClN3O, CAS 1864064-57-2
2-Oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carbonitrile hydrochloride
CAS 1864064-57-2C9H10ClN3O
2-Oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-4-carboxylic acid chemical structure, C9H10N2O3, CAS 1498685-93-0
2-Oxo-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-4-carboxylic acid
CAS 1498685-93-0C9H10N2O3
3-Amino-6-methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one chemical structure, C9H13N3O, CAS 1480247-70-8
3-Amino-6-methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one
CAS 1480247-70-8C9H13N3O
3-Amino-1,6-dimethyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one chemical structure, C10H15N3O, CAS 1483208-57-6
3-Amino-1,6-dimethyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one
CAS 1483208-57-6C10H15N3O