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Murcko scaffold

Ring system with 3 rings and 16 atoms

60 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
60
With full pages
1
Scaffold SMILES

O=C1CC2(CCCc3ccccc32)C(=O)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC2(CCCc3ccccc32)C(=O)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 60 chemicals

Rac 109 chemical structure, C20H28N2O2, CAS 17592-97-1
Rac 109
CAS 17592-97-1C20H28N2O2
Rac 421-II chemical structure, C18H24N2O2, CAS 139085-58-8
Rac 421-II
CAS 139085-58-8C18H24N2O2
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-7-chloro-1'-(2-(dimethylamino)ethyl)- chemical structure, C17H21ClN2O2, CAS 17502-65-7
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-7-chloro-1'-(2-(dimethylamino)ethyl)-
CAS 17502-65-7C17H21ClN2O2
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(2-(dimethylamino)ethyl)-6-methoxy-, hydrochloride chemical structure, C18H25ClN2O3, CAS 17502-67-9
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(2-(dimethylamino)ethyl)-6-methoxy-, hydrochloride
CAS 17502-67-9C18H25ClN2O3
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-(diethylamino)propyl)-6-methoxy-, hydrochloride chemical structure, C21H31ClN2O3, CAS 17502-68-0
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-(diethylamino)propyl)-6-methoxy-, hydrochloride
CAS 17502-68-0C21H31ClN2O3
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-(diethylamino)propyl)-7-isopropoxy-, hydrochloride chemical structure, C23H35ClN2O3, CAS 17502-70-4
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-(diethylamino)propyl)-7-isopropoxy-, hydrochloride
CAS 17502-70-4C23H35ClN2O3
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-(dimethylamino)propyl)-7-methyl- chemical structure, C19H26N2O2, CAS 17502-72-6
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-(dimethylamino)propyl)-7-methyl-
CAS 17502-72-6C19H26N2O2
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(4-(dimethylamino)butyl)-7-hydroxy-, hydrochloride chemical structure, C19H27ClN2O3, CAS 17502-73-7
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(4-(dimethylamino)butyl)-7-hydroxy-, hydrochloride
CAS 17502-73-7C19H27ClN2O3
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(4-(diethylamino)butyl)-7-hydroxy-, hydrochloride chemical structure, C21H31ClN2O3, CAS 17502-74-8
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(4-(diethylamino)butyl)-7-hydroxy-, hydrochloride
CAS 17502-74-8C21H31ClN2O3
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(4-(dimethylamino)butyl)-7-methoxy- chemical structure, C20H28N2O3, CAS 17502-75-9
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(4-(dimethylamino)butyl)-7-methoxy-
CAS 17502-75-9C20H28N2O3
1'-(2-((2-Hydroxyethyl)(methyl)amino)ethyl)-3,4-dihydro-2H-spiro(naphthalene-1,3'-pyrrolidine)-2',5'-dione chemical structure, C18H24N2O3, CAS 17502-76-0
1'-(2-((2-Hydroxyethyl)(methyl)amino)ethyl)-3,4-dihydro-2H-spiro(naphthalene-1,3'-pyrrolidine)-2',5'-dione
CAS 17502-76-0C18H24N2O3
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-(diethylamino)propyl)-7-methyl- chemical structure, C21H30N2O2, CAS 17516-22-2
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-(diethylamino)propyl)-7-methyl-
CAS 17516-22-2C21H30N2O2
1'-(4-(Diethylamino)butyl)-3,4-dihydro-2H-spiro(naphthalene-1,3'-pyrrolidine)-2',5'-dione chemical structure, C21H30N2O2, CAS 28309-58-2
1'-(4-(Diethylamino)butyl)-3,4-dihydro-2H-spiro(naphthalene-1,3'-pyrrolidine)-2',5'-dione
CAS 28309-58-2C21H30N2O2
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(2-(methylamino)ethyl)-, hydrochloride, (±)- chemical structure, C16H21ClN2O2, CAS 74246-71-2
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(2-(methylamino)ethyl)-, hydrochloride, (±)-
CAS 74246-71-2C16H21ClN2O2
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(2-(dimethylamino)ethyl)-, hydrochloride, (±)- chemical structure, C17H23ClN2O2, CAS 74246-72-3
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(2-(dimethylamino)ethyl)-, hydrochloride, (±)-
CAS 74246-72-3C17H23ClN2O2
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(2-(diethylamino)ethyl)-, hydrochloride, (±)- chemical structure, C19H27ClN2O2, CAS 74246-73-4
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(2-(diethylamino)ethyl)-, hydrochloride, (±)-
CAS 74246-73-4C19H27ClN2O2
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(2-(ethyl(2-methoxyethyl)amino)ethyl)-, hydrochloride, (±)- chemical structure, C20H29ClN2O3, CAS 74246-75-6
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(2-(ethyl(2-methoxyethyl)amino)ethyl)-, hydrochloride, (±)-
CAS 74246-75-6C20H29ClN2O3
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(2-((2-ethoxyethyl)ethylamino)ethyl)-, (±)- chemical structure, C21H30N2O3, CAS 74246-76-7
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(2-((2-ethoxyethyl)ethylamino)ethyl)-, (±)-
CAS 74246-76-7C21H30N2O3
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-(dimethylamino)propyl)-, hydrochloride, (±)- chemical structure, C18H25ClN2O2, CAS 74246-78-9
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-(dimethylamino)propyl)-, hydrochloride, (±)-
CAS 74246-78-9C18H25ClN2O2
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-(ethylmethylamino)propyl)-, hydrochloride, (±)- chemical structure, C19H27ClN2O2, CAS 74246-79-0
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-(ethylmethylamino)propyl)-, hydrochloride, (±)-
CAS 74246-79-0C19H27ClN2O2
1'-(3-(Diethylamino)propyl)-3,4-dihydro-2H-spiro(naphthalene-1,3'-pyrrolidine)-2',5'-dione--hydrogen chloride (1/1) chemical structure, C20H29ClN2O2, CAS 74246-80-3
1'-(3-(Diethylamino)propyl)-3,4-dihydro-2H-spiro(naphthalene-1,3'-pyrrolidine)-2',5'-dione--hydrogen chloride (1/1)
CAS 74246-80-3C20H29ClN2O2
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-(methylpropylamino)propyl)-, hydrochloride, (±)- chemical structure, C20H29ClN2O2, CAS 74246-81-4
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-(methylpropylamino)propyl)-, hydrochloride, (±)-
CAS 74246-81-4C20H29ClN2O2
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-((2-hydroxyethyl)methylamino)propyl)-, (±)- chemical structure, C19H26N2O3, CAS 74246-85-8
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-((2-hydroxyethyl)methylamino)propyl)-, (±)-
CAS 74246-85-8C19H26N2O3
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-(ethyl(2-hydroxyethyl)amino)propyl)-, (±)- chemical structure, C20H28N2O3, CAS 74246-86-9
Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(3-(ethyl(2-hydroxyethyl)amino)propyl)-, (±)-
CAS 74246-86-9C20H28N2O3