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Murcko scaffold

Ring system with 3 rings and 25 atoms

19 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 25
Chemicals: 19
With full pages: 3

Scaffold SMILES

O=C(Cc1nnc(SCC(=O)c2ccccc2)[nH]1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Cc1nnc(SCC(=O)c2ccccc2)[nH]1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C21H18BrF3N4O2S, CAS 718603-99-7

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]-N-[3-(trifluoromethyl)phenyl]acetamide

CAS 718603-99-7C₂₁H₁₈BrF₃N₄O₂S

2-[4-Ethyl-5-[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]-N-(2-fluorophenyl)acetamide chemical structure, C21H21FN4O3S, CAS 767326-31-8

2-[4-Ethyl-5-[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]-N-(2-fluorophenyl)acetamide

CAS 767326-31-8C₂₁H₂₁FN₄O₃S

N-(3-Methoxyphenyl)-2-(4-methyl-5-phenacylsulfanyl-1,2,4-triazol-3-yl)acetamide chemical structure, C20H20N4O3S, CAS 713493-12-0

N-(3-Methoxyphenyl)-2-(4-methyl-5-phenacylsulfanyl-1,2,4-triazol-3-yl)acetamide

CAS 713493-12-0C₂₀H₂₀N₄O₃S

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]-N-(4-methylphenyl)acetamide chemical structure, C20H19BrN4O2S, CAS 701970-64-1

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]-N-(4-methylphenyl)acetamide

CAS 701970-64-1C₂₀H₁₉BrN₄O₂S

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-prop-2-enyl-1,2,4-triazol-3-yl]-N-(2-methylphenyl)acetamide chemical structure, C22H21BrN4O2S, CAS 792943-20-5

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-prop-2-enyl-1,2,4-triazol-3-yl]-N-(2-methylphenyl)acetamide

CAS 792943-20-5C₂₂H₂₁BrN₄O₂S

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]-N-(4-methoxyphenyl)acetamide chemical structure, C21H21BrN4O3S, CAS 767325-01-9

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]-N-(4-methoxyphenyl)acetamide

CAS 767325-01-9C₂₁H₂₁BrN₄O₃S

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-prop-2-enyl-1,2,4-triazol-3-yl]-N-(2-methoxyphenyl)acetamide chemical structure, C22H21BrN4O3S, CAS 792943-21-6

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-prop-2-enyl-1,2,4-triazol-3-yl]-N-(2-methoxyphenyl)acetamide

CAS 792943-21-6C₂₂H₂₁BrN₄O₃S

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]-N-(3-chloro-4-methylphenyl)acetamide chemical structure, C20H18BrClN4O2S, CAS 714281-72-8

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]-N-(3-chloro-4-methylphenyl)acetamide

CAS 714281-72-8C₂₀H₁₈BrClN₄O₂S

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]-N-(3,4-dimethylphenyl)acetamide chemical structure, C22H23BrN4O2S, CAS 792943-22-7

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]-N-(3,4-dimethylphenyl)acetamide

CAS 792943-22-7C₂₂H₂₃BrN₄O₂S

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C20H16BrF3N4O2S, CAS 714281-76-2

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]-N-[3-(trifluoromethyl)phenyl]acetamide

CAS 714281-76-2C₂₀H₁₆BrF₃N₄O₂S

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-prop-2-enyl-1,2,4-triazol-3-yl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C22H18BrF3N4O2S, CAS 714281-77-3

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-prop-2-enyl-1,2,4-triazol-3-yl]-N-[3-(trifluoromethyl)phenyl]acetamide

CAS 714281-77-3C₂₂H₁₈BrF₃N₄O₂S

2-[4-Ethyl-5-[2-(3-nitrophenyl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]-N-(4-fluorophenyl)acetamide chemical structure, C20H18FN5O4S, CAS 792943-92-1

2-[4-Ethyl-5-[2-(3-nitrophenyl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]-N-(4-fluorophenyl)acetamide

CAS 792943-92-1C₂₀H₁₈FN₅O₄S

2-[5-[2-(4-Methoxyphenyl)-2-oxoethyl]sulfanyl-4-prop-2-enyl-1,2,4-triazol-3-yl]-N-(2-methylphenyl)acetamide chemical structure, C23H24N4O3S, CAS 792943-50-1

2-[5-[2-(4-Methoxyphenyl)-2-oxoethyl]sulfanyl-4-prop-2-enyl-1,2,4-triazol-3-yl]-N-(2-methylphenyl)acetamide

CAS 792943-50-1C₂₃H₂₄N₄O₃S

2-[4-Ethyl-5-[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]-N-(2-methoxyphenyl)acetamide chemical structure, C22H24N4O4S, CAS 792943-53-4

2-[4-Ethyl-5-[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]-N-(2-methoxyphenyl)acetamide

CAS 792943-53-4C₂₂H₂₄N₄O₄S

N-(2-Methoxyphenyl)-2-[4-methyl-5-[2-(3-nitrophenyl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]acetamide chemical structure, C20H19N5O5S, CAS 792943-90-9

N-(2-Methoxyphenyl)-2-[4-methyl-5-[2-(3-nitrophenyl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]acetamide

CAS 792943-90-9C₂₀H₁₉N₅O₅S

2-[4-Methyl-5-[2-(3-nitrophenyl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]-N-(2-methylphenyl)acetamide chemical structure, C20H19N5O4S, CAS 767326-87-4

2-[4-Methyl-5-[2-(3-nitrophenyl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]-N-(2-methylphenyl)acetamide

CAS 767326-87-4C₂₀H₁₉N₅O₄S

N-(3-Chloro-4-methylphenyl)-2-[4-ethyl-5-[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]acetamide chemical structure, C22H23ClN4O3S, CAS 832091-52-8

N-(3-Chloro-4-methylphenyl)-2-[4-ethyl-5-[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]acetamide

CAS 832091-52-8C₂₂H₂₃ClN₄O₃S

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]-N-(3-methoxyphenyl)acetamide chemical structure, C21H21BrN4O3S, CAS 708282-49-9

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]-N-(3-methoxyphenyl)acetamide

CAS 708282-49-9C₂₁H₂₁BrN₄O₃S

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]-N-(2-methylphenyl)acetamide chemical structure, C20H19BrN4O2S, CAS 767325-00-8

2-[5-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]-N-(2-methylphenyl)acetamide

CAS 767325-00-8C₂₀H₁₉BrN₄O₂S