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Murcko scaffold

Ring system with 3 rings and 25 atoms

17 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 25
Chemicals: 17
With full pages: 10

Scaffold SMILES

O=C(Cc1nnc(SCC(=O)N2CCOCC2)[nH]1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Cc1nnc(SCC(=O)N2CCOCC2)[nH]1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

2-[4-Ethyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]-N-phenylacetamide chemical structure, C18H23N5O3S, CAS 842115-83-7

2-[4-Ethyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]-N-phenylacetamide

CAS 842115-83-7C₁₈H₂₃N₅O₃S

2-[4-Ethyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]-N-(2-fluorophenyl)acetamide chemical structure, C18H22FN5O3S, CAS 892669-90-8

2-[4-Ethyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]-N-(2-fluorophenyl)acetamide

CAS 892669-90-8C₁₈H₂₂FN₅O₃S

2-[4-Ethyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]-N-(4-methoxyphenyl)acetamide chemical structure, C19H25N5O4S, CAS 892670-14-3

2-[4-Ethyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]-N-(4-methoxyphenyl)acetamide

CAS 892670-14-3C₁₉H₂₅N₅O₄S

2-[4-Ethyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]-N-(3-methoxyphenyl)acetamide chemical structure, C19H25N5O4S, CAS 892669-94-2

2-[4-Ethyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]-N-(3-methoxyphenyl)acetamide

CAS 892669-94-2C₁₉H₂₅N₅O₄S

2-[4-Methyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]-N-(2-methylphenyl)acetamide chemical structure, C18H23N5O3S, CAS 892670-06-3

2-[4-Methyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]-N-(2-methylphenyl)acetamide

CAS 892670-06-3C₁₈H₂₃N₅O₃S

2-[4-Ethyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]-N-(4-fluorophenyl)acetamide chemical structure, C18H22FN5O3S, CAS 892670-20-1

2-[4-Ethyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]-N-(4-fluorophenyl)acetamide

CAS 892670-20-1C₁₈H₂₂FN₅O₃S

N-(2,4-Dimethylphenyl)-2-[5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-4-prop-2-enyl-1,2,4-triazol-3-yl]acetamide chemical structure, C21H27N5O3S, CAS 892670-22-3

N-(2,4-Dimethylphenyl)-2-[5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-4-prop-2-enyl-1,2,4-triazol-3-yl]acetamide

CAS 892670-22-3C₂₁H₂₇N₅O₃S

N-(4-Chlorophenyl)-2-[4-ethyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]acetamide chemical structure, C18H22ClN5O3S, CAS 892670-17-6

N-(4-Chlorophenyl)-2-[4-ethyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]acetamide

CAS 892670-17-6C₁₈H₂₂ClN₅O₃S

N-(4-Chlorophenyl)-2-[4-methyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]acetamide chemical structure, C17H20ClN5O3S, CAS 892670-08-5

N-(4-Chlorophenyl)-2-[4-methyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]acetamide

CAS 892670-08-5C₁₇H₂₀ClN₅O₃S

N-(4-Ethoxyphenyl)-2-[4-methyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]acetamide chemical structure, C19H25N5O4S, CAS 892670-11-0

N-(4-Ethoxyphenyl)-2-[4-methyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-1,2,4-triazol-3-yl]acetamide

CAS 892670-11-0C₁₉H₂₅N₅O₄S

N-(4-Fluorophenyl)-2-[5-{[2-(morpholin-4-yl)-2-oxoethyl]sulfanyl}-4-(prop-2-en-1-yl)-4H-1,2,4-triazol-3-yl]acetamide chemical structure, C19H22FN5O3S, CAS 892704-65-3

N-(4-Fluorophenyl)-2-[5-{[2-(morpholin-4-yl)-2-oxoethyl]sulfanyl}-4-(prop-2-en-1-yl)-4H-1,2,4-triazol-3-yl]acetamide

CAS 892704-65-3C₁₉H₂₂FN₅O₃S

N-(4-Fluorophenyl)-2-(4-methyl-5-{[2-(morpholin-4-yl)-2-oxoethyl]sulfanyl}-4H-1,2,4-triazol-3-yl)acetamide chemical structure, C17H20FN5O3S, CAS 906214-57-1

N-(4-Fluorophenyl)-2-(4-methyl-5-{[2-(morpholin-4-yl)-2-oxoethyl]sulfanyl}-4H-1,2,4-triazol-3-yl)acetamide

CAS 906214-57-1C₁₇H₂₀FN₅O₃S

2-(4-Ethyl-5-{[2-(morpholin-4-yl)-2-oxoethyl]sulfanyl}-4H-1,2,4-triazol-3-yl)-N-(2-methylphenyl)acetamide chemical structure, C19H25N5O3S, CAS 906214-61-7

2-(4-Ethyl-5-{[2-(morpholin-4-yl)-2-oxoethyl]sulfanyl}-4H-1,2,4-triazol-3-yl)-N-(2-methylphenyl)acetamide

CAS 906214-61-7C₁₉H₂₅N₅O₃S

2-(4-Ethyl-5-{[2-(morpholin-4-yl)-2-oxoethyl]sulfanyl}-4H-1,2,4-triazol-3-yl)-N-(3-methylphenyl)acetamide chemical structure, C19H25N5O3S, CAS 906214-75-3

2-(4-Ethyl-5-{[2-(morpholin-4-yl)-2-oxoethyl]sulfanyl}-4H-1,2,4-triazol-3-yl)-N-(3-methylphenyl)acetamide

CAS 906214-75-3C₁₉H₂₅N₅O₃S

2-(4-Methyl-5-{[2-(morpholin-4-yl)-2-oxoethyl]sulfanyl}-4H-1,2,4-triazol-3-yl)-N-(4-methylphenyl)acetamide chemical structure, C18H23N5O3S, CAS 906212-65-5

2-(4-Methyl-5-{[2-(morpholin-4-yl)-2-oxoethyl]sulfanyl}-4H-1,2,4-triazol-3-yl)-N-(4-methylphenyl)acetamide

CAS 906212-65-5C₁₈H₂₃N₅O₃S

N-(3-Methylphenyl)-2-[5-{[2-(morpholin-4-yl)-2-oxoethyl]sulfanyl}-4-(prop-2-en-1-yl)-4H-1,2,4-triazol-3-yl]acetamide chemical structure, C20H25N5O3S, CAS 917214-97-2

N-(3-Methylphenyl)-2-[5-{[2-(morpholin-4-yl)-2-oxoethyl]sulfanyl}-4-(prop-2-en-1-yl)-4H-1,2,4-triazol-3-yl]acetamide

CAS 917214-97-2C₂₀H₂₅N₅O₃S

N-(3-Chloro-4-methylphenyl)-2-(4-methyl-5-{[2-(morpholin-4-yl)-2-oxoethyl]sulfanyl}-4H-1,2,4-triazol-3-yl)acetamide chemical structure, C18H22ClN5O3S, CAS 950245-80-4

N-(3-Chloro-4-methylphenyl)-2-(4-methyl-5-{[2-(morpholin-4-yl)-2-oxoethyl]sulfanyl}-4H-1,2,4-triazol-3-yl)acetamide

CAS 950245-80-4C₁₈H₂₂ClN₅O₃S