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Murcko scaffold

Ring system with 3 rings and 26 atoms

14 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
26
Chemicals
14
With full pages
5
Scaffold SMILES

O=C(CN1C(=O)SC(=CC=Cc2ccccc2)C1=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN1C(=O)SC(=CC=Cc2ccccc2)C1=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

4-[({(5Z)-2,4-Dioxo-5-[(2E)-3-phenylprop-2-enylidene]-1,3-thiazolidin-3-yl}acetyl)amino]benzoic acid chemical structure, C21H16N2O5S, CAS 315236-35-2
4-[({(5Z)-2,4-Dioxo-5-[(2E)-3-phenylprop-2-enylidene]-1,3-thiazolidin-3-yl}acetyl)amino]benzoic acid
CAS 315236-35-2C21H16N2O5S
2-[5-((2E)-3-Phenylprop-2-enylidene)-2,4-dioxo(1,3-thiazolidin-3-yl)]-N-(4-chl orophenyl)acetamide chemical structure, C20H15ClN2O3S, CAS 425648-41-5
2-[5-((2E)-3-Phenylprop-2-enylidene)-2,4-dioxo(1,3-thiazolidin-3-yl)]-N-(4-chl orophenyl)acetamide
CAS 425648-41-5C20H15ClN2O3S
2-(2-((Z)-2,4-Dioxo-5-((E)-3-phenylallylidene)thiazolidin-3-yl)acetamido)benzoic acid chemical structure, C21H16N2O5S, CAS 315236-33-0
2-(2-((Z)-2,4-Dioxo-5-((E)-3-phenylallylidene)thiazolidin-3-yl)acetamido)benzoic acid
CAS 315236-33-0C21H16N2O5S
2-((Z)-2,4-Dioxo-5-((E)-3-phenylallylidene)thiazolidin-3-yl)-N-(4-hydroxyphenyl)acetamide chemical structure, C20H16N2O4S, CAS 1164461-15-7
2-((Z)-2,4-Dioxo-5-((E)-3-phenylallylidene)thiazolidin-3-yl)-N-(4-hydroxyphenyl)acetamide
CAS 1164461-15-7C20H16N2O4S
N-(4-Hydroxyphenyl)-2-[5-(2-methyl-3-phenyl-2-propen-1-ylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide chemical structure, C21H18N2O4S, CAS 1164535-51-6
N-(4-Hydroxyphenyl)-2-[5-(2-methyl-3-phenyl-2-propen-1-ylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide
CAS 1164535-51-6C21H18N2O4S
N-(3-Hydroxyphenyl)-2-[5-(2-methyl-3-phenyl-2-propen-1-ylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide chemical structure, C21H18N2O4S, CAS 1164525-35-2
N-(3-Hydroxyphenyl)-2-[5-(2-methyl-3-phenyl-2-propen-1-ylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide
CAS 1164525-35-2C21H18N2O4S
N-(2-Hydroxyphenyl)-2-{(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-2,4-dioxo-1,3-thiazolidin-3-yl}acetamide chemical structure, C21H18N2O4S, CAS 371235-59-5
N-(2-Hydroxyphenyl)-2-{(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-2,4-dioxo-1,3-thiazolidin-3-yl}acetamide
CAS 371235-59-5C21H18N2O4S
N-(4-Methoxyphenyl)-2-((Z)-5-((E)-2-methyl-3-phenylallylidene)-2,4-dioxothiazolidin-3-yl)acetamide chemical structure, C22H20N2O4S, CAS 428859-47-6
N-(4-Methoxyphenyl)-2-((Z)-5-((E)-2-methyl-3-phenylallylidene)-2,4-dioxothiazolidin-3-yl)acetamide
CAS 428859-47-6C22H20N2O4S
Ethyl 4-[({(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-2,4-dioxo-1,3-thiazolidin-3-yl}acetyl)amino]benzoate chemical structure, C24H22N2O5S, CAS 385373-97-7
Ethyl 4-[({(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-2,4-dioxo-1,3-thiazolidin-3-yl}acetyl)amino]benzoate
CAS 385373-97-7C24H22N2O5S
4-(2-((E)-5-((E)-2-Methyl-3-phenylallylidene)-2,4-dioxothiazolidin-3-yl)acetamido)benzoic acid chemical structure, C22H18N2O5S, CAS 370870-70-5
4-(2-((E)-5-((E)-2-Methyl-3-phenylallylidene)-2,4-dioxothiazolidin-3-yl)acetamido)benzoic acid
CAS 370870-70-5C22H18N2O5S
2-((Z)-2,4-Dioxo-5-((E)-3-phenylallylidene)thiazolidin-3-yl)-N-(4-fluorophenyl)acetamide chemical structure, C20H15FN2O3S, CAS 639509-38-9
2-((Z)-2,4-Dioxo-5-((E)-3-phenylallylidene)thiazolidin-3-yl)-N-(4-fluorophenyl)acetamide
CAS 639509-38-9C20H15FN2O3S
2-((Z)-2,4-Dioxo-5-((E)-3-phenylallylidene)thiazolidin-3-yl)-N-(4-sulfamoylphenyl)acetamide chemical structure, C20H17N3O5S2, CAS 433239-89-5
2-((Z)-2,4-Dioxo-5-((E)-3-phenylallylidene)thiazolidin-3-yl)-N-(4-sulfamoylphenyl)acetamide
CAS 433239-89-5C20H17N3O5S2
2-[(5E)-5-{(2E)-3-[4-(Dimethylamino)phenyl]prop-2-en-1-ylidene}-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(3,4-dimethylphenyl)acetamide chemical structure, C24H25N3O3S, CAS 432497-87-5
2-[(5E)-5-{(2E)-3-[4-(Dimethylamino)phenyl]prop-2-en-1-ylidene}-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(3,4-dimethylphenyl)acetamide
CAS 432497-87-5C24H25N3O3S
4-[({(5Z)-2,4-Dioxo-5-[(2E)-3-phenylprop-2-en-1-ylidene]-1,3-thiazolidin-3-yl}acetyl)amino]-2-hydroxybenzoic acid chemical structure, C21H16N2O6S, CAS 902329-05-9
4-[({(5Z)-2,4-Dioxo-5-[(2E)-3-phenylprop-2-en-1-ylidene]-1,3-thiazolidin-3-yl}acetyl)amino]-2-hydroxybenzoic acid
CAS 902329-05-9C21H16N2O6S