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Murcko scaffold

Ring system with 3 rings and 27 atoms

29 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 27
Chemicals: 29
With full pages: 2

Scaffold SMILES

O=C(C=C1SC(=O)N(CC(=O)Nc2ccccc2)C1=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(C=C1SC(=O)N(CC(=O)Nc2ccccc2)C1=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-(phenylamino)ethyl)thiazolidin-5-ylidene)-N-(4-methoxyphenyl)acetamide chemical structure, C20H17N3O5S, CAS 692762-71-3

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-(phenylamino)ethyl)thiazolidin-5-ylidene)-N-(4-methoxyphenyl)acetamide

CAS 692762-71-3C₂₀H₁₇N₃O₅S

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-(m-tolylamino)ethyl)thiazolidin-5-ylidene)-N-(p-tolyl)acetamide chemical structure, C21H19N3O4S, CAS 692762-76-8

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-(m-tolylamino)ethyl)thiazolidin-5-ylidene)-N-(p-tolyl)acetamide

CAS 692762-76-8C₂₁H₁₉N₃O₄S

N-(4-Chlorophenyl)-2-[(5Z)-5-[2-(4-fluoroanilino)-2-oxoethylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide chemical structure, C19H13ClFN3O4S, CAS 1164460-60-9

N-(4-Chlorophenyl)-2-[(5Z)-5-[2-(4-fluoroanilino)-2-oxoethylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide

CAS 1164460-60-9C₁₉H₁₃ClFN₃O₄S

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-(phenylamino)ethyl)thiazolidin-5-ylidene)-N-phenylacetamide chemical structure, C19H15N3O4S, CAS 692762-69-9

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-(phenylamino)ethyl)thiazolidin-5-ylidene)-N-phenylacetamide

CAS 692762-69-9C₁₉H₁₅N₃O₄S

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-(phenylamino)ethyl)thiazolidin-5-ylidene)-N-(4-fluorophenyl)acetamide chemical structure, C19H14FN3O4S, CAS 692762-73-5

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-(phenylamino)ethyl)thiazolidin-5-ylidene)-N-(4-fluorophenyl)acetamide

CAS 692762-73-5C₁₉H₁₄FN₃O₄S

(Z)-N-(4-Chlorophenyl)-2-(2,4-dioxo-3-(2-oxo-2-(phenylamino)ethyl)thiazolidin-5-ylidene)acetamide chemical structure, C19H14ClN3O4S, CAS 692762-74-6

(Z)-N-(4-Chlorophenyl)-2-(2,4-dioxo-3-(2-oxo-2-(phenylamino)ethyl)thiazolidin-5-ylidene)acetamide

CAS 692762-74-6C₁₉H₁₄ClN₃O₄S

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-(m-tolylamino)ethyl)thiazolidin-5-ylidene)-N-phenylacetamide chemical structure, C20H17N3O4S, CAS 692762-75-7

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-(m-tolylamino)ethyl)thiazolidin-5-ylidene)-N-phenylacetamide

CAS 692762-75-7C₂₀H₁₇N₃O₄S

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-((2-(trifluoromethyl)phenyl)amino)ethyl)thiazolidin-5-ylidene)-N-(4-fluorophenyl)acetamide chemical structure, C20H13F4N3O4S, CAS 781656-67-5

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-((2-(trifluoromethyl)phenyl)amino)ethyl)thiazolidin-5-ylidene)-N-(4-fluorophenyl)acetamide

CAS 781656-67-5C₂₀H₁₃F₄N₃O₄S

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-((4-sulfamoylphenyl)amino)ethyl)thiazolidin-5-ylidene)-N-phenylacetamide chemical structure, C19H16N4O6S2, CAS 692762-80-4

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-((4-sulfamoylphenyl)amino)ethyl)thiazolidin-5-ylidene)-N-phenylacetamide

CAS 692762-80-4C₁₉H₁₆N₄O₆S₂

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-((4-sulfamoylphenyl)amino)ethyl)thiazolidin-5-ylidene)-N-(p-tolyl)acetamide chemical structure, C20H18N4O6S2, CAS 1942846-73-2

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-((4-sulfamoylphenyl)amino)ethyl)thiazolidin-5-ylidene)-N-(p-tolyl)acetamide

CAS 1942846-73-2C₂₀H₁₈N₄O₆S₂

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-((4-sulfamoylphenyl)amino)ethyl)thiazolidin-5-ylidene)-N-(4-fluorophenyl)acetamide chemical structure, C19H15FN4O6S2, CAS 867041-24-5

(Z)-2-(2,4-Dioxo-3-(2-oxo-2-((4-sulfamoylphenyl)amino)ethyl)thiazolidin-5-ylidene)-N-(4-fluorophenyl)acetamide

CAS 867041-24-5C₁₉H₁₅FN₄O₆S₂

(Z)-N-(4-Chlorophenyl)-2-(2,4-dioxo-3-(2-oxo-2-((4-sulfamoylphenyl)amino)ethyl)thiazolidin-5-ylidene)acetamide chemical structure, C19H15ClN4O6S2, CAS 867041-23-4

(Z)-N-(4-Chlorophenyl)-2-(2,4-dioxo-3-(2-oxo-2-((4-sulfamoylphenyl)amino)ethyl)thiazolidin-5-ylidene)acetamide

CAS 867041-23-4C₁₉H₁₅ClN₄O₆S₂

(Z)-N-(4-Fluorophenyl)-2-(3-(2-((4-fluorophenyl)amino)-2-oxoethyl)-2,4-dioxothiazolidin-5-ylidene)acetamide chemical structure, C19H13F2N3O4S, CAS 867041-20-1

(Z)-N-(4-Fluorophenyl)-2-(3-(2-((4-fluorophenyl)amino)-2-oxoethyl)-2,4-dioxothiazolidin-5-ylidene)acetamide

CAS 867041-20-1C₁₉H₁₃F₂N₃O₄S

2-[(5Z)-5-[2-(4-Chloroanilino)-2-oxoethylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-fluorophenyl)acetamide chemical structure, C19H13ClFN3O4S, CAS 1164524-65-5

2-[(5Z)-5-[2-(4-Chloroanilino)-2-oxoethylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-fluorophenyl)acetamide

CAS 1164524-65-5C₁₉H₁₃ClFN₃O₄S

2-[(5Z)-5-[2-(4-Fluoroanilino)-2-oxoethylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(3-methylphenyl)acetamide chemical structure, C20H16FN3O4S, CAS 867041-30-3

2-[(5Z)-5-[2-(4-Fluoroanilino)-2-oxoethylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(3-methylphenyl)acetamide

CAS 867041-30-3C₂₀H₁₆FN₃O₄S

(Z)-N-(4-Chlorophenyl)-2-(2,4-dioxo-3-(2-oxo-2-(m-tolylamino)ethyl)thiazolidin-5-ylidene)acetamide chemical structure, C20H16ClN3O4S, CAS 1164524-51-9

(Z)-N-(4-Chlorophenyl)-2-(2,4-dioxo-3-(2-oxo-2-(m-tolylamino)ethyl)thiazolidin-5-ylidene)acetamide

CAS 1164524-51-9C₂₀H₁₆ClN₃O₄S

2-[(5Z)-5-[2-(4-Fluoroanilino)-2-oxoethylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C20H13F4N3O4S, CAS 867041-28-9

2-[(5Z)-5-[2-(4-Fluoroanilino)-2-oxoethylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-[3-(trifluoromethyl)phenyl]acetamide

CAS 867041-28-9C₂₀H₁₃F₄N₃O₄S

2-[(5Z)-5-[2-(4-Chloroanilino)-2-oxoethylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C20H13ClF3N3O4S, CAS 867041-29-0

2-[(5Z)-5-[2-(4-Chloroanilino)-2-oxoethylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-[3-(trifluoromethyl)phenyl]acetamide

CAS 867041-29-0C₂₀H₁₃ClF₃N₃O₄S

(Z)-N-(4-Chlorophenyl)-2-(2,4-dioxo-3-(2-oxo-2-((2-(trifluoromethyl)phenyl)amino)ethyl)thiazolidin-5-ylidene)acetamide chemical structure, C20H13ClF3N3O4S, CAS 867041-34-7

(Z)-N-(4-Chlorophenyl)-2-(2,4-dioxo-3-(2-oxo-2-((2-(trifluoromethyl)phenyl)amino)ethyl)thiazolidin-5-ylidene)acetamide

CAS 867041-34-7C₂₀H₁₃ClF₃N₃O₄S

2-[(5Z)-5-[2-(4-Chloroanilino)-2-oxoethylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide chemical structure, C20H16ClN3O4S, CAS 1164518-75-5

2-[(5Z)-5-[2-(4-Chloroanilino)-2-oxoethylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide

CAS 1164518-75-5C₂₀H₁₆ClN₃O₄S

(Z)-N-(4-Chlorophenyl)-2-(3-(2-((4-chlorophenyl)amino)-2-oxoethyl)-2,4-dioxothiazolidin-5-ylidene)acetamide chemical structure, C19H13Cl2N3O4S, CAS 867041-19-8

(Z)-N-(4-Chlorophenyl)-2-(3-(2-((4-chlorophenyl)amino)-2-oxoethyl)-2,4-dioxothiazolidin-5-ylidene)acetamide

CAS 867041-19-8C₁₉H₁₃Cl₂N₃O₄S

2-[(5Z)-5-{[(4-Fluorophenyl)carbamoyl]methylidene}-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide chemical structure, C20H16FN3O4S, CAS 880796-62-3

2-[(5Z)-5-{[(4-Fluorophenyl)carbamoyl]methylidene}-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide

CAS 880796-62-3C₂₀H₁₆FN₃O₄S

(Z)-Ethyl 4-(2-(2,4-dioxo-3-(2-oxo-2-(phenylamino)ethyl)thiazolidin-5-ylidene)acetamido)benzoate chemical structure, C22H19N3O6S, CAS 692762-72-4

(Z)-Ethyl 4-(2-(2,4-dioxo-3-(2-oxo-2-(phenylamino)ethyl)thiazolidin-5-ylidene)acetamido)benzoate

CAS 692762-72-4C₂₂H₁₉N₃O₆S

(Z)-Ethyl 4-(2-(2,4-dioxo-3-(2-oxo-2-((4-sulfamoylphenyl)amino)ethyl)thiazolidin-5-ylidene)acetamido)benzoate chemical structure, C22H20N4O8S2, CAS 692762-82-6

(Z)-Ethyl 4-(2-(2,4-dioxo-3-(2-oxo-2-((4-sulfamoylphenyl)amino)ethyl)thiazolidin-5-ylidene)acetamido)benzoate

CAS 692762-82-6C₂₂H₂₀N₄O₈S₂