Murcko scaffold
2-(Phenoxymethyl)-1H-imidazole scaffold
51 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 13
- Chemicals
- 51
- With full pages
- 7
Scaffold SMILES
c1ccc(OCc2ncc[nH]2)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold c1ccc(OCc2ncc[nH]2)cc1](/scaffold/JMZUTNMUXBNVPD-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 51 chemicals
Fexinidazole
CAS 59729-37-2C12H13N3O3S
1H-Imidazole, 2-(phenoxymethyl)-, monohydrochloride
CAS 43111-21-3C10H11ClN2O
2-(Phenoxymethyl)-1H-imidazole
CAS 752924-01-9C10H10N2O
1H-Imidazole, 2-((3-chlorophenoxy)methyl)-, monohydrochloride
CAS 43111-23-5C10H10Cl2N2O
1H-Imidazole, 2-((4-chlorophenoxy)methyl)-, monohydrochloride
CAS 43111-24-6C10H10Cl2N2O
1H-Imidazole, 2-((3,4-dichlorophenoxy)methyl)-, monohydrochloride
CAS 43111-25-7C10H9Cl3N2O
1H-Imidazole, 2-((4-methoxyphenoxy)methyl)-, monohydrochloride
CAS 43111-27-9C11H13ClN2O2
1H-Imidazole, 2-((2-chlorophenoxy)methyl)-, monohydrochloride
CAS 29786-72-9C10H10Cl2N2O
![4-[(1-Methyl-1H-imidazol-2-yl)methoxy]benzaldehyde chemical structure, C12H12N2O2, CAS 118001-71-1](/s/DMUKYFSMBNHCHM-UHFFFAOYSA-N.svg)
4-[(1-Methyl-1H-imidazol-2-yl)methoxy]benzaldehyde
CAS 118001-71-1C12H12N2O2
![5-Chloro-1-methyl-2-[(5-methyl-2-nitrophenoxy)methyl]imidazole chemical structure, C12H12ClN3O3, CAS 879302-67-7](/s/RGCJHAGTSZDPPU-UHFFFAOYSA-N.svg)
5-Chloro-1-methyl-2-[(5-methyl-2-nitrophenoxy)methyl]imidazole
CAS 879302-67-7C12H12ClN3O3
![4-[(1-Methyl-1H-imidazol-2-yl)methoxy]benzaldehyde oxime chemical structure, C12H13N3O2, CAS 887575-91-9](/s/WLMXKWOSOIXTIU-RIYZIHGNSA-N.svg)
4-[(1-Methyl-1H-imidazol-2-yl)methoxy]benzaldehyde oxime
CAS 887575-91-9C12H13N3O2
![1-Methyl-2-[4-(dimethylaminomethyleneamino)phenoxymethyl]-5-nitro-1H-imidazole chemical structure, C14H17N5O3, CAS 61799-91-5](/s/OTYINWYVVXNPJC-UHFFFAOYSA-N.svg)
1-Methyl-2-[4-(dimethylaminomethyleneamino)phenoxymethyl]-5-nitro-1H-imidazole
CAS 61799-91-5C14H17N5O3
3-Chloro-4-((1-methyl-1H-imidazol-2-yl)methoxy)aniline
CAS 179687-84-4C11H12ClN3O
4-((1-Methyl-5-nitro-1H-imidazol-2-yl)methoxy)aniline
CAS 61800-00-8C11H12N4O3
![2-{[4-(Methanesulfinyl)phenoxy]methyl}-1-methyl-5-nitro-1H-imidazole chemical structure, C12H13N3O4S, CAS 62351-99-9](/s/HBDLZYHJBXDDJM-UHFFFAOYSA-N.svg)
2-{[4-(Methanesulfinyl)phenoxy]methyl}-1-methyl-5-nitro-1H-imidazole
CAS 62351-99-9C12H13N3O4S
![2-{[4-(Ethanesulfinyl)phenoxy]methyl}-1-methyl-5-nitro-1H-imidazole chemical structure, C13H15N3O4S, CAS 62352-00-5](/s/GXTVOQVRERBPSB-UHFFFAOYSA-N.svg)
2-{[4-(Ethanesulfinyl)phenoxy]methyl}-1-methyl-5-nitro-1H-imidazole
CAS 62352-00-5C13H15N3O4S
Fexinidazole sulfone
CAS 64570-18-9C12H13N3O5S
![2-Methyl-4-[(1-methyl-5-nitro-1H-imidazol-2-yl)methoxy]benzonitrile chemical structure, C13H12N4O3, CAS 64580-34-3](/s/UNJPPZBYOPFXHK-UHFFFAOYSA-N.svg)
2-Methyl-4-[(1-methyl-5-nitro-1H-imidazol-2-yl)methoxy]benzonitrile
CAS 64580-34-3C13H12N4O3
![4-[(1-Methyl-5-nitro-1H-imidazol-2-yl)methoxy]benzonitrile chemical structure, C12H10N4O3, CAS 60768-32-3](/s/PHJZBIKWWAHKEA-UHFFFAOYSA-N.svg)
4-[(1-Methyl-5-nitro-1H-imidazol-2-yl)methoxy]benzonitrile
CAS 60768-32-3C12H10N4O3
![4-[(1-Methyl-1H-imidazol-2-yl)methoxy]aniline chemical structure, C11H13N3O, CAS 1146290-31-4](/s/ZDKSIKJGUOTJJK-UHFFFAOYSA-N.svg)
4-[(1-Methyl-1H-imidazol-2-yl)methoxy]aniline
CAS 1146290-31-4C11H13N3O
![1-{4-[(1-Methyl-1H-imidazol-2-yl)methoxy]phenyl}ethan-1-one chemical structure, C13H14N2O2, CAS 1094382-05-4](/s/WHBBMCFOFMDJBZ-UHFFFAOYSA-N.svg)
1-{4-[(1-Methyl-1H-imidazol-2-yl)methoxy]phenyl}ethan-1-one
CAS 1094382-05-4C13H14N2O2
![2-{4-[(1-Methyl-1H-imidazol-2-yl)methoxy]phenyl}ethan-1-amine chemical structure, C13H17N3O, CAS 1181346-01-9](/s/PEQZNJJJIKHFPP-UHFFFAOYSA-N.svg)
2-{4-[(1-Methyl-1H-imidazol-2-yl)methoxy]phenyl}ethan-1-amine
CAS 1181346-01-9C13H17N3O
![4-[(1-Methyl-1H-imidazol-2-yl)methoxy]benzoic acid chemical structure, C12H12N2O3, CAS 1094451-54-3](/s/FRSXOQOLPYKWIS-UHFFFAOYSA-N.svg)
4-[(1-Methyl-1H-imidazol-2-yl)methoxy]benzoic acid
CAS 1094451-54-3C12H12N2O3
![3-Methoxy-4-[(1-methyl-1H-imidazol-2-yl)methoxy]benzaldehyde chemical structure, C13H14N2O3, CAS 1096925-63-1](/s/CMKVVFHFCIPNDM-UHFFFAOYSA-N.svg)
3-Methoxy-4-[(1-methyl-1H-imidazol-2-yl)methoxy]benzaldehyde
CAS 1096925-63-1C13H14N2O3
- 2-[4-(Chloromethyl)phenoxymethyl]-1-methyl-1H-imidazole1170775-81-1C12H13ClN2O
- {4-[(1-Methyl-1H-imidazol-2-yl)methoxy]phenyl}methanol1094451-64-5C12H14N2O2
- 2-[4-(Chloromethyl)phenoxymethyl]-1-methyl-1H-imidazole hydrochloride1170478-93-9C12H14Cl2N2O
- 2-[(4-Bromophenoxy)methyl]-5-chloro-1-methyl-1H-imidazole1094306-76-9C11H10BrClN2O
- 2-(4-Bromophenoxymethyl)-1-(difluoromethyl)-1H-imidazole1152545-67-9C11H9BrF2N2O
- 2-((2-Bromo-4-fluorophenoxy)methyl)-1-(difluoromethyl)-1H-imidazole1094415-85-6C11H8BrF3N2O
- 2-[(2-Bromo-4-methylphenoxy)methyl]-1-methyl-1H-imidazole1152568-00-7C12H13BrN2O
- 2-[[1-(Difluoromethyl)-1H-imidazol-2-yl]methoxy]phenol1094451-91-8C11H10F2N2O2
- 3-Methyl-4-[(1-methyl-1H-imidazol-2-yl)methoxy]aniline793646-28-3C12H15N3O
- 5-Bromo-2-{[1-(2,2,2-trifluoroethyl)-1H-imidazol-2-yl]methoxy}benzaldehyde1311623-58-1C13H10BrF3N2O2
- 1H-Imidazole, 5-chloro-1-methyl-2-[[4-(methylthio)phenoxy]methyl]-1270127-86-0C12H13ClN2OS
- 2-{[4-(Ethylsulfanyl)phenoxy]methyl}-1-methyl-5-nitro-1H-imidazole62351-98-8C13H15N3O3S
- 1-(3-((1-Ethyl-1H-imidazol-2-yl)methoxy)phenyl)ethan-1-one1285421-30-8C14H16N2O2
- Benzoic acid, 3-hydroxy-5-[(1-methyl-1H-imidazol-2-yl)methoxy]-, methyl ester927908-27-8C13H14N2O4
- 5-Methoxy-2-[(1-methyl-1H-imidazol-2-yl)methoxy]-N-propylbenzenemethanamine1178275-83-6C16H23N3O2
- 3-Bromo-4-[[1-(difluoromethyl)-1H-imidazol-2-yl]methoxy]-5-methoxybenzenemethanamine1182797-08-5C13H14BrF2N3O2
- (2-(Phenoxymethyl)-1H-imidazol-5-yl)methanol1340285-29-1C11H12N2O2
- 4-[(1-Methyl-1H-imidazol-2-yl)methoxy]benzoic acid hydrochloride1318776-59-8C12H13ClN2O3
- 2-[(4-Bromo-2-methoxyphenoxy)methyl]-1-methyl-1H-imidazole956002-44-1C12H13BrN2O2
- 1-Ethyl-2-{[4-(methylsulfanyl)phenoxy]methyl}-5-nitro-1H-imidazole67266-44-8C13H15N3O3S
- Methyl 5-fluoro-2-((1-methyl-1H-imidazol-2-yl)methoxy)benzoate1363404-98-1C13H13FN2O3
- 5-Fluoro-2-((1-methyl-1H-imidazol-2-yl)methoxy)benzoic acid1363405-32-6C12H11FN2O3
- 2-((1-Methyl-1H-imidazol-2-yl)methoxy)-5-nitrobenzene-1-sulfonyl chloride1545171-20-7C11H10ClN3O5S
- N-[2-[4-[(1-Methylimidazol-2-yl)methoxy]phenyl]ethyl]prop-2-enamide2411224-19-4C16H19N3O2
Related scaffolds
Same ring framework with different atoms or bond orders
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O=C(Nc1ccccc1)c1cccs1150 chemicals
O=C(Nc1nccs1)c1ccccc1121 chemicals![Scaffold O=C(N=c1[nH]ncs1)c1ccccc1](/scaffold/RWOUBULBQYRRNL-UHFFFAOYSA-N/structure.svg)
O=C(N=c1[nH]ncs1)c1ccccc187 chemicals
c1ccc(OCc2ccco2)cc175 chemicals
O=S(=O)(Nc1nccs1)c1ccccc161 chemicals![Scaffold c1ccc(CSc2ncn[nH]2)cc1](/scaffold/IQQYSQRJFHUASD-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2ncn[nH]2)cc160 chemicals![Scaffold O=C(Nc1ccccc1)c1cc[nH]n1](/scaffold/WMZYZYFPPQOFKY-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)c1cc[nH]n160 chemicals
O=C(Nc1cccs1)c1ccccc152 chemicals
O=C(Nc1ccccc1)C1CCCO150 chemicals
O=C(Nc1ccccc1)c1ccoc148 chemicals
c1ccc(CSc2nncs2)cc144 chemicals