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Murcko scaffold

Ring system with 2 rings and 14 atoms

28 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
14
Chemicals
28
With full pages
5
Scaffold SMILES

C(=NNc1nccs1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C(=NNc1nccs1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

4-Thiazolecarboxylic acid, 2-[(phenylmethylene)hydrazino]-, ethyl ester chemical structure, C13H13N3O2S, CAS 67618-38-6
4-Thiazolecarboxylic acid, 2-[(phenylmethylene)hydrazino]-, ethyl ester
CAS 67618-38-6C13H13N3O2S
Ethyl 2-[2-[(2E)-2-[(2-methoxyphenyl)methylidene]hydrazinyl]-1,3-thiazol-4-yl]acetate chemical structure, C15H17N3O3S, CAS 6147-92-8
Ethyl 2-[2-[(2E)-2-[(2-methoxyphenyl)methylidene]hydrazinyl]-1,3-thiazol-4-yl]acetate
CAS 6147-92-8C15H17N3O3S
N-[(2-Fluorophenyl)methylideneamino]-4-methyl-1,3-thiazol-2-amine chemical structure, C11H10FN3S, CAS 425403-47-0
N-[(2-Fluorophenyl)methylideneamino]-4-methyl-1,3-thiazol-2-amine
CAS 425403-47-0C11H10FN3S
Benzoic acid, 4-[(2-thiazolylhydrazono)methyl]- chemical structure, C11H9N3O2S, CAS 89408-28-6
Benzoic acid, 4-[(2-thiazolylhydrazono)methyl]-
CAS 89408-28-6C11H9N3O2S
Methyl 4-[[2-(4,5-dimethyl-2-thiazolyl)hydrazinylidene]methyl]benzoate chemical structure, C14H15N3O2S, CAS 351521-83-0
Methyl 4-[[2-(4,5-dimethyl-2-thiazolyl)hydrazinylidene]methyl]benzoate
CAS 351521-83-0C14H15N3O2S
(Z)-Ethyl 2-(2-(2-(4-butoxybenzylidene)hydrazinyl)thiazol-4-yl)acetate chemical structure, C18H23N3O3S, CAS 6133-47-7
(Z)-Ethyl 2-(2-(2-(4-butoxybenzylidene)hydrazinyl)thiazol-4-yl)acetate
CAS 6133-47-7C18H23N3O3S
(E)-Ethyl 2-(2-(4-(diethylamino)benzylidene)hydrazinyl)-4-methylthiazole-5-carboxylate chemical structure, C18H24N4O2S, CAS 307528-39-8
(E)-Ethyl 2-(2-(4-(diethylamino)benzylidene)hydrazinyl)-4-methylthiazole-5-carboxylate
CAS 307528-39-8C18H24N4O2S
N-[(E)-(2-Chloro-6-fluorophenyl)methylideneamino]-4-methyl-1,3-thiazol-2-amine chemical structure, C11H9ClFN3S, CAS 347914-43-6
N-[(E)-(2-Chloro-6-fluorophenyl)methylideneamino]-4-methyl-1,3-thiazol-2-amine
CAS 347914-43-6C11H9ClFN3S
Ethyl 2-[2-[(2E)-2-[[4-(dimethylamino)phenyl]methylidene]hydrazinyl]-1,3-thiazol-4-yl]acetate chemical structure, C16H20N4O2S, CAS 37072-82-5
Ethyl 2-[2-[(2E)-2-[[4-(dimethylamino)phenyl]methylidene]hydrazinyl]-1,3-thiazol-4-yl]acetate
CAS 37072-82-5C16H20N4O2S
3,4-Dichlorobenzaldehyde (5-acetyl-4-methyl-1,3-thiazol-2-yl)hydrazone chemical structure, C13H11Cl2N3OS, CAS 466643-54-9
3,4-Dichlorobenzaldehyde (5-acetyl-4-methyl-1,3-thiazol-2-yl)hydrazone
CAS 466643-54-9C13H11Cl2N3OS
Ethyl {2-[(2E)-2-benzylidenehydrazinyl]-1,3-thiazol-4-yl}acetate chemical structure, C14H15N3O2S, CAS 37072-41-6
Ethyl {2-[(2E)-2-benzylidenehydrazinyl]-1,3-thiazol-4-yl}acetate
CAS 37072-41-6C14H15N3O2S
2-[(2Z)-2-[(4-Bromophenyl)methylidene]hydrazinyl]-1,3-thiazole-4-carboxylate chemical structure, C11H7BrN3O2S-, CAS 136513-94-5
2-[(2Z)-2-[(4-Bromophenyl)methylidene]hydrazinyl]-1,3-thiazole-4-carboxylate
CAS 136513-94-5C11H7BrN3O2S-
2-{(2Z)-2-[(4-Methoxyphenyl)methylidene]hydrazin-1-yl}-1,3-thiazole-4-carboxylate chemical structure, C12H10N3O3S-, CAS 136513-93-4
2-{(2Z)-2-[(4-Methoxyphenyl)methylidene]hydrazin-1-yl}-1,3-thiazole-4-carboxylate
CAS 136513-93-4C12H10N3O3S-
N-[(E)-Benzylideneamino]-4-methyl-1,3-thiazol-2-amine chemical structure, C11H11N3S, CAS 37072-50-7
N-[(E)-Benzylideneamino]-4-methyl-1,3-thiazol-2-amine
CAS 37072-50-7C11H11N3S
1-(4-Methoxyphenyl)ethanone (5-acetyl-4-methyl-1,3-thiazol-2-yl)hydrazone chemical structure, C15H17N3O2S, CAS 315707-26-7
1-(4-Methoxyphenyl)ethanone (5-acetyl-4-methyl-1,3-thiazol-2-yl)hydrazone
CAS 315707-26-7C15H17N3O2S
4-[(4-Methyl-thiazol-2-ylhydrazono)-methyl]-benzoic acid chemical structure, C12H11N3O2S, CAS 99989-28-3
4-[(4-Methyl-thiazol-2-ylhydrazono)-methyl]-benzoic acid
CAS 99989-28-3C12H11N3O2S
4-[(E)-{2-[5-(Ethoxycarbonyl)-4-methyl-1,3-thiazol-2-yl]hydrazinylidene}methyl]benzoic acid chemical structure, C15H15N3O4S, CAS 469877-18-7
4-[(E)-{2-[5-(Ethoxycarbonyl)-4-methyl-1,3-thiazol-2-yl]hydrazinylidene}methyl]benzoic acid
CAS 469877-18-7C15H15N3O4S
(E)-1-(2-(2-(3-Hydroxybenzylidene)hydrazinyl)-4-methylthiazol-5-yl)ethanone chemical structure, C13H13N3O2S, CAS 464211-86-7
(E)-1-(2-(2-(3-Hydroxybenzylidene)hydrazinyl)-4-methylthiazol-5-yl)ethanone
CAS 464211-86-7C13H13N3O2S
4-(Chloromethyl)-2-(2-{[4-(propan-2-yl)phenyl]methylidene}hydrazin-1-yl)-1,3-thiazole chemical structure, C14H16ClN3S, CAS 750608-13-0
4-(Chloromethyl)-2-(2-{[4-(propan-2-yl)phenyl]methylidene}hydrazin-1-yl)-1,3-thiazole
CAS 750608-13-0C14H16ClN3S
(E)-1-(2-(2-(2-Methoxybenzylidene)hydrazinyl)-4-methylthiazol-5-yl)ethanone chemical structure, C14H15N3O2S, CAS 464210-68-2
(E)-1-(2-(2-(2-Methoxybenzylidene)hydrazinyl)-4-methylthiazol-5-yl)ethanone
CAS 464210-68-2C14H15N3O2S
N-[4-(Chloromethyl)-1,3-thiazol-2-yl]-N'-[(4-methylphenyl)methylidene]acetohydrazide chemical structure, C14H14ClN3OS, CAS 749902-35-0
N-[4-(Chloromethyl)-1,3-thiazol-2-yl]-N'-[(4-methylphenyl)methylidene]acetohydrazide
CAS 749902-35-0C14H14ClN3OS
4-Nitrobenzaldehyde 2-(2-thiazolyl)hydrazone chemical structure, C10H8N4O2S, CAS 99361-85-0
4-Nitrobenzaldehyde 2-(2-thiazolyl)hydrazone
CAS 99361-85-0C10H8N4O2S
4-Ethoxy-3,5-dimethoxybenzaldehyde 2-(2-thiazolyl)hydrazone chemical structure, C14H17N3O3S, CAS 156027-07-5
4-Ethoxy-3,5-dimethoxybenzaldehyde 2-(2-thiazolyl)hydrazone
CAS 156027-07-5C14H17N3O3S
(E)-2-((2-(4-Methylthiazol-2-yl)hydrazono)methyl)phenol chemical structure, C11H11N3OS, CAS 302804-77-9
(E)-2-((2-(4-Methylthiazol-2-yl)hydrazono)methyl)phenol
CAS 302804-77-9C11H11N3OS