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Murcko scaffold

1-(Thien-2-ylcarbonyl)piperazine scaffold

74 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
74
With full pages
9
Scaffold SMILES

O=C(c1cccs1)N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Thien-2-ylcarbonyl)piperazine page
Murcko scaffold O=C(c1cccs1)N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 74 chemicals

(4-Propylsulfonylpiperazin-1-yl)-thiophen-2-ylmethanone chemical structure, C12H18N2O3S2, CAS 428836-69-5
(4-Propylsulfonylpiperazin-1-yl)-thiophen-2-ylmethanone
CAS 428836-69-5C12H18N2O3S2
Ethyl 4-(2-thienylcarbonyl)piperazinecarboxylate chemical structure, C12H16N2O3S, CAS 333430-62-9
Ethyl 4-(2-thienylcarbonyl)piperazinecarboxylate
CAS 333430-62-9C12H16N2O3S
[4-(Propan-2-yl)piperazin-1-yl](thiophen-2-yl)methanone chemical structure, C12H18N2OS, CAS 461409-27-8
[4-(Propan-2-yl)piperazin-1-yl](thiophen-2-yl)methanone
CAS 461409-27-8C12H18N2OS
(4-Ethylsulfonylpiperazin-1-yl)-thiophen-2-ylmethanone chemical structure, C11H16N2O3S2, CAS 428505-13-9
(4-Ethylsulfonylpiperazin-1-yl)-thiophen-2-ylmethanone
CAS 428505-13-9C11H16N2O3S2
1-(3-Methylbutanoyl)-4-(2-thienylcarbonyl)piperazine chemical structure, C14H20N2O2S, CAS 333756-79-9
1-(3-Methylbutanoyl)-4-(2-thienylcarbonyl)piperazine
CAS 333756-79-9C14H20N2O2S
1-(Thien-2-ylcarbonyl)piperazine chemical structure, C9H12N2OS, CAS 52063-83-9
1-(Thien-2-ylcarbonyl)piperazine
CAS 52063-83-9C9H12N2OS
N,N-Dimethyl-4-(thiophene-2-carbonyl)piperazine-1-sulfonamide chemical structure, C11H17N3O3S2, CAS 700849-30-5
N,N-Dimethyl-4-(thiophene-2-carbonyl)piperazine-1-sulfonamide
CAS 700849-30-5C11H17N3O3S2
2-Chloro-1-[4-(thiophene-2-carbonyl)piperazin-1-yl]ethan-1-one chemical structure, C11H13ClN2O2S, CAS 852389-12-9
2-Chloro-1-[4-(thiophene-2-carbonyl)piperazin-1-yl]ethan-1-one
CAS 852389-12-9C11H13ClN2O2S
tert-Butyl 4-(thiophene-2-carbonyl)piperazine-1-carboxylate chemical structure, C14H20N2O3S, CAS 473733-88-9
tert-Butyl 4-(thiophene-2-carbonyl)piperazine-1-carboxylate
CAS 473733-88-9C14H20N2O3S
1-sec-Butyl-4-(2-thienylcarbonyl)piperazine chemical structure, C13H20N2OS, CAS 462604-38-2
1-sec-Butyl-4-(2-thienylcarbonyl)piperazine
CAS 462604-38-2C13H20N2OS
Methanone, (4-methyl-1-piperazinyl)(3-methyl-2-thienyl)- chemical structure, C11H16N2OS, CAS 515859-98-0
Methanone, (4-methyl-1-piperazinyl)(3-methyl-2-thienyl)-
CAS 515859-98-0C11H16N2OS
(5-Chlorothiophen-2-yl)-(4-prop-2-enylpiperazin-1-yl)methanone chemical structure, C12H15ClN2OS, CAS 886632-83-3
(5-Chlorothiophen-2-yl)-(4-prop-2-enylpiperazin-1-yl)methanone
CAS 886632-83-3C12H15ClN2OS
(4-Bromo-5-ethylthiophen-2-yl)-(4-prop-2-enylpiperazin-1-yl)methanone chemical structure, C14H19BrN2OS, CAS 904380-05-8
(4-Bromo-5-ethylthiophen-2-yl)-(4-prop-2-enylpiperazin-1-yl)methanone
CAS 904380-05-8C14H19BrN2OS
(4-Prop-2-enylpiperazin-1-yl)-thiophen-2-ylmethanone chemical structure, C12H16N2OS, CAS 886629-02-3
(4-Prop-2-enylpiperazin-1-yl)-thiophen-2-ylmethanone
CAS 886629-02-3C12H16N2OS
(5-Bromothiophen-2-yl)-(4-prop-2-enylpiperazin-1-yl)methanone chemical structure, C12H15BrN2OS, CAS 898135-23-4
(5-Bromothiophen-2-yl)-(4-prop-2-enylpiperazin-1-yl)methanone
CAS 898135-23-4C12H15BrN2OS
(5-Bromo-2-thienyl)(piperazino)methanone chemical structure, C9H11BrN2OS, CAS 395648-06-3
(5-Bromo-2-thienyl)(piperazino)methanone
CAS 395648-06-3C9H11BrN2OS
1-(5-Nitrothiophene-2-carbonyl)piperazine chemical structure, C9H11N3O3S, CAS 104554-65-6
1-(5-Nitrothiophene-2-carbonyl)piperazine
CAS 104554-65-6C9H11N3O3S
(5-Bromothiophen-2-yl)(4-methylpiperazin-1-yl)methanone chemical structure, C10H13BrN2OS, CAS 945192-25-6
(5-Bromothiophen-2-yl)(4-methylpiperazin-1-yl)methanone
CAS 945192-25-6C10H13BrN2OS
1-(5-Methylthiophene-2-carbonyl)piperazine chemical structure, C10H14N2OS, CAS 1016723-39-9
1-(5-Methylthiophene-2-carbonyl)piperazine
CAS 1016723-39-9C10H14N2OS
1-Amino-4-(2-thenoyl)piperazine chemical structure, C9H13N3OS, CAS 133920-82-8
1-Amino-4-(2-thenoyl)piperazine
CAS 133920-82-8C9H13N3OS
1-(4-(5-Bromothiophene-2-carbonyl)piperazin-1-yl)ethan-1-one chemical structure, C11H13BrN2O2S, CAS 1090500-12-1
1-(4-(5-Bromothiophene-2-carbonyl)piperazin-1-yl)ethan-1-one
CAS 1090500-12-1C11H13BrN2O2S
tert-Butyl 4-(5-bromothiophene-2-carbonyl)piperazine-1-carboxylate chemical structure, C14H19BrN2O3S, CAS 1017782-71-6
tert-Butyl 4-(5-bromothiophene-2-carbonyl)piperazine-1-carboxylate
CAS 1017782-71-6C14H19BrN2O3S
(4-Ethylpiperazin-1-yl)-(5-ethylthiophen-2-yl)methanone chemical structure, C13H20N2OS, CAS 950226-32-1
(4-Ethylpiperazin-1-yl)-(5-ethylthiophen-2-yl)methanone
CAS 950226-32-1C13H20N2OS
(2-[4-(2-Thienylcarbonyl)piperazin-1-yl]ethyl)amine chemical structure, C11H17N3OS, CAS 1018255-96-3
(2-[4-(2-Thienylcarbonyl)piperazin-1-yl]ethyl)amine
CAS 1018255-96-3C11H17N3OS