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Murcko scaffold

3-Anilino-2,3-dihydro-1H-1lambda~6~-thiophene-1,1-dione scaffold

136 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
14
Chemicals
136
With full pages
20
Scaffold SMILES

O=S1(=O)C=CC(Nc2ccccc2)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-Anilino-2,3-dihydro-1H-1lambda~6~-thiophene-1,1-dione page
Murcko scaffold O=S1(=O)C=CC(Nc2ccccc2)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 136 chemicals

3-Anilino-2,3-dihydro-1H-1lambda~6~-thiophene-1,1-dione chemical structure, C10H11NO2S, CAS 39565-69-0
3-Anilino-2,3-dihydro-1H-1lambda~6~-thiophene-1,1-dione
CAS 39565-69-0C10H11NO2S
2-Chloro-N-(1,1-dioxo-2,3-dihydro-1lambda6-thiophen-3-yl)-N-phenylacetamide chemical structure, C12H12ClNO3S, CAS 392314-55-5
2-Chloro-N-(1,1-dioxo-2,3-dihydro-1lambda6-thiophen-3-yl)-N-phenylacetamide
CAS 392314-55-5C12H12ClNO3S
N-(3,4-Dimethylphenyl)-1,1-dioxo-2,3-dihydrothiophen-3-amine chemical structure, C12H15NO2S, CAS 301229-94-7
N-(3,4-Dimethylphenyl)-1,1-dioxo-2,3-dihydrothiophen-3-amine
CAS 301229-94-7C12H15NO2S
3-(p-Tolylamino)-2,3-dihydrothiophene 1,1-dioxide chemical structure, C11H13NO2S, CAS 39565-71-4
3-(p-Tolylamino)-2,3-dihydrothiophene 1,1-dioxide
CAS 39565-71-4C11H13NO2S
3-[(3-Methylphenyl)amino]-2,3-dihydro-1lambda6-thiophene-1,1-dione chemical structure, C11H13NO2S, CAS 39565-72-5
3-[(3-Methylphenyl)amino]-2,3-dihydro-1lambda6-thiophene-1,1-dione
CAS 39565-72-5C11H13NO2S
3-((4-Methoxyphenyl)amino)-2,3-dihydrothiophene 1,1-dioxide chemical structure, C11H13NO3S, CAS 39760-05-9
3-((4-Methoxyphenyl)amino)-2,3-dihydrothiophene 1,1-dioxide
CAS 39760-05-9C11H13NO3S
3-((4-Chlorophenyl)amino)-2,3-dihydrothiophene 1,1-dioxide chemical structure, C10H10ClNO2S, CAS 39565-75-8
3-((4-Chlorophenyl)amino)-2,3-dihydrothiophene 1,1-dioxide
CAS 39565-75-8C10H10ClNO2S
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-phenylacetamide chemical structure, C12H13NO3S, CAS 325984-41-6
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-phenylacetamide
CAS 325984-41-6C12H13NO3S
N-(4-Chlorophenyl)-N-(1,1-dioxo-2,3-dihydrothiophen-3-yl)-2,2,2-trifluoroacetamide chemical structure, C12H9ClF3NO3S, CAS 302950-44-3
N-(4-Chlorophenyl)-N-(1,1-dioxo-2,3-dihydrothiophen-3-yl)-2,2,2-trifluoroacetamide
CAS 302950-44-3C12H9ClF3NO3S
Ethyl 3-[(1,1-dioxo-2,3-dihydrothiophen-3-yl)amino]benzoate chemical structure, C13H15NO4S, CAS 302948-90-9
Ethyl 3-[(1,1-dioxo-2,3-dihydrothiophen-3-yl)amino]benzoate
CAS 302948-90-9C13H15NO4S
2,2,2-Trichloro-N-(1,1-dioxo-2,3-dihydrothiophen-3-yl)-N-(2-methoxyphenyl)acetamide chemical structure, C13H12Cl3NO4S, CAS 6104-44-5
2,2,2-Trichloro-N-(1,1-dioxo-2,3-dihydrothiophen-3-yl)-N-(2-methoxyphenyl)acetamide
CAS 6104-44-5C13H12Cl3NO4S
N-(3,4-Dimethylphenyl)-N-(1,1-dioxo-2,3-dihydrothiophen-3-yl)-2,2,2-trifluoroacetamide chemical structure, C14H14F3NO3S, CAS 325984-99-4
N-(3,4-Dimethylphenyl)-N-(1,1-dioxo-2,3-dihydrothiophen-3-yl)-2,2,2-trifluoroacetamide
CAS 325984-99-4C14H14F3NO3S
N-(1,1-Dioxido-2,3-dihydrothien-3-yl)-N-[3-(trifluoromethyl)phenyl]amine chemical structure, C11H10F3NO2S, CAS 6110-32-3
N-(1,1-Dioxido-2,3-dihydrothien-3-yl)-N-[3-(trifluoromethyl)phenyl]amine
CAS 6110-32-3C11H10F3NO2S
Ethyl 4-[(1,1-dioxido-2,3-dihydrothiophen-3-yl)amino]benzoate chemical structure, C13H15NO4S, CAS 302948-91-0
Ethyl 4-[(1,1-dioxido-2,3-dihydrothiophen-3-yl)amino]benzoate
CAS 302948-91-0C13H15NO4S
N-(2-Methoxyphenyl)-1,1-dioxo-2,3-dihydrothiophen-3-amine chemical structure, C11H13NO3S, CAS 40508-70-1
N-(2-Methoxyphenyl)-1,1-dioxo-2,3-dihydrothiophen-3-amine
CAS 40508-70-1C11H13NO3S
N-(1,1-Dioxido-2,3-dihydro-3-thienyl)-N-(3-methoxyphenyl)acetamide chemical structure, C13H15NO4S, CAS 294851-33-5
N-(1,1-Dioxido-2,3-dihydro-3-thienyl)-N-(3-methoxyphenyl)acetamide
CAS 294851-33-5C13H15NO4S
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(3-(trifluoromethyl)phenyl)acetamide chemical structure, C13H12F3NO3S, CAS 538338-37-3
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(3-(trifluoromethyl)phenyl)acetamide
CAS 538338-37-3C13H12F3NO3S
N-(2,3-Dimethylphenyl)-N-(1,1-dioxo(3-2,3-dihydrothienyl))acetamide chemical structure, C14H17NO3S, CAS 620590-11-6
N-(2,3-Dimethylphenyl)-N-(1,1-dioxo(3-2,3-dihydrothienyl))acetamide
CAS 620590-11-6C14H17NO3S
N-(4-Ethoxyphenyl)-1,1-dioxo-2,3-dihydrothiophen-3-amine chemical structure, C12H15NO3S, CAS 620590-04-7
N-(4-Ethoxyphenyl)-1,1-dioxo-2,3-dihydrothiophen-3-amine
CAS 620590-04-7C12H15NO3S
N-(2,3-Dimethylphenyl)-1,1-dioxo-2,3-dihydrothiophen-3-amine chemical structure, C12H15NO2S, CAS 620590-03-6
N-(2,3-Dimethylphenyl)-1,1-dioxo-2,3-dihydrothiophen-3-amine
CAS 620590-03-6C12H15NO2S
N-(4-Bromophenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)acetamide chemical structure, C12H12BrNO3S, CAS 620543-78-4
N-(4-Bromophenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)acetamide
CAS 620543-78-4C12H12BrNO3S
N-(1,1-Dioxido-2,3-dihydro-3-thienyl)-N-(4-ethylphenyl)acetamide chemical structure, C14H17NO3S, CAS 718603-18-0
N-(1,1-Dioxido-2,3-dihydro-3-thienyl)-N-(4-ethylphenyl)acetamide
CAS 718603-18-0C14H17NO3S
N-(3-Chlorophenyl)-1,1-dioxo-2,3-dihydrothiophen-3-amine chemical structure, C10H10ClNO2S, CAS 321977-85-9
N-(3-Chlorophenyl)-1,1-dioxo-2,3-dihydrothiophen-3-amine
CAS 321977-85-9C10H10ClNO2S
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(2-methoxyphenyl)acetamide chemical structure, C13H15NO4S, CAS 329202-71-3
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(2-methoxyphenyl)acetamide
CAS 329202-71-3C13H15NO4S