Murcko scaffold
2-Phenylpyrazolo[1,5-a]pyrimidin-7-ol scaffold
65 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 16
- Chemicals
- 65
- With full pages
- 17
Scaffold SMILES
O=c1ccnc2cc(-c3ccccc3)[nH]n12
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=c1ccnc2cc(-c3ccccc3)[nH]n12](/scaffold/LCIWNFJRZJKIJM-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 65 chemicals
![2-(4-tert-Butyl-phenyl)-5-methyl-4H-pyrazolo[1,5-a]pyrimidin-7-one chemical structure, C17H19N3O, CAS 309938-89-4](/s/RVNYCWOXUCOSMF-UHFFFAOYSA-N.svg)
2-(4-tert-Butyl-phenyl)-5-methyl-4H-pyrazolo[1,5-a]pyrimidin-7-one
CAS 309938-89-4C17H19N3O
![6-Ethyl-2-(4-iodo-phenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C15H14IN3O, CAS 331962-25-5](/s/CJBQKQYSDIZPOH-UHFFFAOYSA-N.svg)
6-Ethyl-2-(4-iodo-phenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-7-ol
CAS 331962-25-5C15H14IN3O
![6-Chloro-2-(4-iodo-phenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C13H9ClIN3O, CAS 420828-80-4](/s/FOODICXZEFPWFL-UHFFFAOYSA-N.svg)
6-Chloro-2-(4-iodo-phenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-7-ol
CAS 420828-80-4C13H9ClIN3O
![5-Propyl-2-p-tolyl-4H-pyrazolo[1,5-a]pyrimidin-7-one chemical structure, C16H17N3O, CAS 423746-38-7](/s/MERRDVXKSSIBGD-UHFFFAOYSA-N.svg)
5-Propyl-2-p-tolyl-4H-pyrazolo[1,5-a]pyrimidin-7-one
CAS 423746-38-7C16H17N3O
![2-(4-Bromophenyl)-6-ethyl-5-methylpyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C15H14BrN3O, CAS 310422-21-0](/s/ZIKKOPULQCJPQF-UHFFFAOYSA-N.svg)
2-(4-Bromophenyl)-6-ethyl-5-methylpyrazolo[1,5-a]pyrimidin-7-ol
CAS 310422-21-0C15H14BrN3O
![2-(4-Bromophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C13H10BrN3O, CAS 312278-48-1](/s/LOPRPQCEFSPKLL-UHFFFAOYSA-N.svg)
2-(4-Bromophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-ol
CAS 312278-48-1C13H10BrN3O
![2-(4-Bromophenyl)-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one chemical structure, C14H12BrN3O2, CAS 309294-10-8](/s/UGOJTPASRRPMJB-UHFFFAOYSA-N.svg)
2-(4-Bromophenyl)-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
CAS 309294-10-8C14H12BrN3O2
![5-Methyl-2-(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C14H13N3O, CAS 700847-30-9](/s/JWNOATYNIBJLTP-UHFFFAOYSA-N.svg)
5-Methyl-2-(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-7-ol
CAS 700847-30-9C14H13N3O
5-Methyl-2-phenyl-4H,7H-pyrazolo(1,5-a)pyrimidin-7-one
CAS 65774-92-7C13H11N3O
![Ethyl [2-(4-chlorophenyl)-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]acetate chemical structure, C17H16ClN3O3, CAS 535965-52-7](/s/DWUHRNUWACTCHZ-UHFFFAOYSA-N.svg)
Ethyl [2-(4-chlorophenyl)-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]acetate
CAS 535965-52-7C17H16ClN3O3
![Ethyl [5-methyl-2-(4-methylphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]acetate chemical structure, C18H19N3O3, CAS 528561-40-2](/s/RHTQFXCILLIJQC-UHFFFAOYSA-N.svg)
Ethyl [5-methyl-2-(4-methylphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]acetate
CAS 528561-40-2C18H19N3O3
![Ethyl (7-hydroxy-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)acetate chemical structure, C17H17N3O3, CAS 65774-95-0](/s/XECCDFKDHWSBRX-UHFFFAOYSA-N.svg)
Ethyl (7-hydroxy-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)acetate
CAS 65774-95-0C17H17N3O3
![2-Phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7(4H)-one chemical structure, C15H15N3O, CAS 331962-22-2](/s/AKVHSVCAFZXALB-UHFFFAOYSA-N.svg)
2-Phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7(4H)-one
CAS 331962-22-2C15H15N3O
![5-(Methoxymethyl)-2-(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one chemical structure, C15H15N3O2, CAS 309938-85-0](/s/LOGPJQWKUIIQTN-UHFFFAOYSA-N.svg)
5-(Methoxymethyl)-2-(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
CAS 309938-85-0C15H15N3O2
![2-(4-Chlorophenyl)-6-ethyl-5-methylpyrazolo[1,5-a]pyrimidin-7(1H)-one chemical structure, C15H14ClN3O, CAS 5789-68-4](/s/BQGULYXQMSQQNW-UHFFFAOYSA-N.svg)
2-(4-Chlorophenyl)-6-ethyl-5-methylpyrazolo[1,5-a]pyrimidin-7(1H)-one
CAS 5789-68-4C15H14ClN3O
![2-(3-Chloro-phenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C13H10ClN3O, CAS 5992-54-1](/s/HKDOMFTZBNBVHI-UHFFFAOYSA-N.svg)
2-(3-Chloro-phenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-7-ol
CAS 5992-54-1C13H10ClN3O
![3,5-Dimethyl-2-phenyl-pyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C14H13N3O, CAS 332899-45-3](/s/FHUUZYDXEYDHKA-UHFFFAOYSA-N.svg)
3,5-Dimethyl-2-phenyl-pyrazolo[1,5-a]pyrimidin-7-ol
CAS 332899-45-3C14H13N3O
![2-(4-Chloro-phenyl)-5-propyl-pyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C15H14ClN3O, CAS 389074-47-9](/s/MUZUKINXCIFOLT-UHFFFAOYSA-N.svg)
2-(4-Chloro-phenyl)-5-propyl-pyrazolo[1,5-a]pyrimidin-7-ol
CAS 389074-47-9C15H14ClN3O
![6-Allyl-2-(4-bromophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C16H14BrN3O, CAS 331962-28-8](/s/ZZLRGAXKFNQEJP-UHFFFAOYSA-N.svg)
6-Allyl-2-(4-bromophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-ol
CAS 331962-28-8C16H14BrN3O
![Ethyl [2-(4-chlorophenyl)-7-hydroxypyrazolo[1,5-a]pyrimidin-5-yl]acetate chemical structure, C16H14ClN3O3, CAS 862676-80-0](/s/HOLKTKZWWZXXSZ-UHFFFAOYSA-N.svg)
Ethyl [2-(4-chlorophenyl)-7-hydroxypyrazolo[1,5-a]pyrimidin-5-yl]acetate
CAS 862676-80-0C16H14ClN3O3
![5,6-Dimethyl-2-phenylpyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C14H13N3O, CAS 158501-30-5](/s/URYZABDSMGMPEL-UHFFFAOYSA-N.svg)
5,6-Dimethyl-2-phenylpyrazolo[1,5-a]pyrimidin-7-ol
CAS 158501-30-5C14H13N3O
![6-Chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C13H10ClN3O, CAS 189018-17-5](/s/SSAJCSRUENTPGH-UHFFFAOYSA-N.svg)
6-Chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-7-ol
CAS 189018-17-5C13H10ClN3O
![6-Chloro-2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C13H9Cl2N3O, CAS 331674-94-3](/s/OUUDUDIJKKUWSC-UHFFFAOYSA-N.svg)
6-Chloro-2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-ol
CAS 331674-94-3C13H9Cl2N3O
![2-(4-Bromo-phenyl)-6-chloro-5-methyl-pyrazolo[1,5-a]pyrimidin-7-ol chemical structure, C13H9BrClN3O, CAS 331674-98-7](/s/HWJSABXGOVTHQK-UHFFFAOYSA-N.svg)
2-(4-Bromo-phenyl)-6-chloro-5-methyl-pyrazolo[1,5-a]pyrimidin-7-ol
CAS 331674-98-7C13H9BrClN3O
- 5-Methyl-2-m-tolyl-pyrazolo[1,5-a]pyrimidin-7-ol331422-49-2C14H13N3O
- 5-Methyl-2-(2-methylphenyl)pyrazolo[1,5-a]pyrimidin-7-ol331422-50-5C14H13N3O
- 2-(4-Methoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one331422-51-6C14H13N3O2
- 2-(4-Chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-ol13097-27-3C13H10ClN3O
- Ethyl 2-(2-chlorophenyl)-7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate333325-44-3C15H12ClN3O3
- 2-(3-Methylphenyl)-5-propyl-1H-pyrazolo[1,5-a]pyrimidin-7-one6137-42-4C16H17N3O
- 3-Methyl-2-(4-methylphenyl)-5-propyl-1H-pyrazolo[1,5-a]pyrimidin-7-one6161-56-4C17H19N3O
- Ethyl [7-hydroxy-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl]acetate838815-99-9C17H17N3O4
- Ethyl 2-(4-bromophenyl)-7-hydroxypyrazolo[1,5-a]pyrimidine-5-carboxylate331675-00-4C15H12BrN3O3
- Ethyl 7-hydroxy-2-(4-iodophenyl)pyrazolo[1,5-a]pyrimidine-6-carboxylate331739-38-9C15H12IN3O3
- Ethyl [2-(4-tert-butylphenyl)-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]acetate527708-69-6C21H25N3O3
- Ethyl [7-hydroxy-2-(3-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl]acetate606116-30-7C17H17N3O4
- Ethyl 3-[2-(3-methoxyphenyl)-5-methyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidin-6-yl]propanoate606116-31-8C19H21N3O4
- Ethyl 7-hydroxy-2-(3-methoxyphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxylate606116-32-9C16H15N3O4
- 6-Ethyl-2-(3-methoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-ol606116-34-1C16H17N3O2
- Ethyl 3-[7-hydroxy-2-(4-methoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]propanoate606116-36-3C19H21N3O4
- 2-(3,4-Dimethoxyphenyl)-6-ethyl-5-methyl-1H-pyrazolo[1,5-a]pyrimidin-7-one606116-40-9C17H19N3O3
- 6-Chloro-2-(3,5-dimethoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-ol606116-47-6C15H14ClN3O3
- 2-(3,5-Dimethoxyphenyl)-5,6-dimethylpyrazolo[1,5-a]pyrimidin-7-ol606116-48-7C16H17N3O3
- 2-(3,5-Dimethoxyphenyl)-5-propyl-pyrazolo[1,5-a]pyrimidin-7-ol606116-49-8C17H19N3O3
- 2-(3,5-Dimethoxyphenyl)-6-ethyl-5-methylpyrazolo[1,5-a]pyrimidin-7-ol606116-52-3C17H19N3O3
- 2-(3,4-Dichlorophenyl)-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidin-7-ol439095-83-7C14H11Cl2N3O2
- Ethyl 3-(2-(4-iodophenyl)-5-methyl-7-oxo-1,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)propanoate6048-49-3C18H18IN3O3
- 3-Bromo-5-methyl-2-phenyl-1H-pyrazolo[1,5-a]pyrimidin-7-one93214-01-8C13H10BrN3O
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