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Murcko scaffold

Ring system with 4 rings and 26 atoms

113 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
113
With full pages
3
Scaffold SMILES

O=C1C(=O)N(c2ccccc2)C(c2ccccc2)C1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=O)N(c2ccccc2)C(c2ccccc2)C1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 113 chemicals

(4E)-5-(4-Chlorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-nitrophenyl)pyrrolidine-2,3-dione chemical structure, C23H15ClN2O5, CAS 337492-31-6
(4E)-5-(4-Chlorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-nitrophenyl)pyrrolidine-2,3-dione
CAS 337492-31-6C23H15ClN2O5
(4E)-4-[Hydroxy(phenyl)methylidene]-1-(3-methoxyphenyl)-5-(4-methoxyphenyl)pyrrolidine-2,3-dione chemical structure, C25H21NO5, CAS 337492-51-0
(4E)-4-[Hydroxy(phenyl)methylidene]-1-(3-methoxyphenyl)-5-(4-methoxyphenyl)pyrrolidine-2,3-dione
CAS 337492-51-0C25H21NO5
(4E)-5-(4-Chlorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methoxyphenyl)pyrrolidine-2,3-dione chemical structure, C24H18ClNO4, CAS 337492-55-4
(4E)-5-(4-Chlorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methoxyphenyl)pyrrolidine-2,3-dione
CAS 337492-55-4C24H18ClNO4
4-Benzoyl-3-hydroxy-1-(3-methoxyphenyl)-5-(4-nitrophenyl)-1H-pyrrol-2(5H)-one chemical structure, C24H18N2O6, CAS 309725-71-1
4-Benzoyl-3-hydroxy-1-(3-methoxyphenyl)-5-(4-nitrophenyl)-1H-pyrrol-2(5H)-one
CAS 309725-71-1C24H18N2O6
(4E)-5-(4-Fluorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methoxyphenyl)pyrrolidine-2,3-dione chemical structure, C24H18FNO4, CAS 337492-59-8
(4E)-5-(4-Fluorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methoxyphenyl)pyrrolidine-2,3-dione
CAS 337492-59-8C24H18FNO4
(4E)-5-(2-Fluorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methoxyphenyl)pyrrolidine-2,3-dione chemical structure, C24H18FNO4, CAS 337492-61-2
(4E)-5-(2-Fluorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methoxyphenyl)pyrrolidine-2,3-dione
CAS 337492-61-2C24H18FNO4
(4E)-5-(2,4-Dimethoxyphenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methoxyphenyl)pyrrolidine-2,3-dione chemical structure, C26H23NO6, CAS 333434-32-5
(4E)-5-(2,4-Dimethoxyphenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methoxyphenyl)pyrrolidine-2,3-dione
CAS 333434-32-5C26H23NO6
4-Benzoyl-5-(3,4-dimethoxyphenyl)-3-hydroxy-1-(3-methoxyphenyl)-1H-pyrrol-2(5H)-one chemical structure, C26H23NO6, CAS 333434-34-7
4-Benzoyl-5-(3,4-dimethoxyphenyl)-3-hydroxy-1-(3-methoxyphenyl)-1H-pyrrol-2(5H)-one
CAS 333434-34-7C26H23NO6
5-(4-Chlorophenyl)-3-hydroxy-1-(4-hydroxyphenyl)-4-[(4-methylphenyl)carbonyl]-3-pyrrolin-2-one chemical structure, C24H18ClNO4, CAS 332357-46-7
5-(4-Chlorophenyl)-3-hydroxy-1-(4-hydroxyphenyl)-4-[(4-methylphenyl)carbonyl]-3-pyrrolin-2-one
CAS 332357-46-7C24H18ClNO4
(4E)-5-(4-Bromophenyl)-4-[hydroxy-(4-methylphenyl)methylidene]-1-(4-hydroxyphenyl)pyrrolidine-2,3-dione chemical structure, C24H18BrNO4, CAS 332357-47-8
(4E)-5-(4-Bromophenyl)-4-[hydroxy-(4-methylphenyl)methylidene]-1-(4-hydroxyphenyl)pyrrolidine-2,3-dione
CAS 332357-47-8C24H18BrNO4
3-Benzoyl-4-hydroxy-2-(3-nitrophenyl)-1-phenyl-2H-pyrrol-5-one chemical structure, C23H16N2O5, CAS 331751-19-0
3-Benzoyl-4-hydroxy-2-(3-nitrophenyl)-1-phenyl-2H-pyrrol-5-one
CAS 331751-19-0C23H16N2O5
4-Benzoyl-3-hydroxy-1-(4-methoxyphenyl)-5-(3-nitrophenyl)-1H-pyrrol-2(5H)-one chemical structure, C24H18N2O6, CAS 425423-72-9
4-Benzoyl-3-hydroxy-1-(4-methoxyphenyl)-5-(3-nitrophenyl)-1H-pyrrol-2(5H)-one
CAS 425423-72-9C24H18N2O6
(4E)-1-(4-Bromophenyl)-4-[hydroxy(phenyl)methylidene]-5-(3-nitrophenyl)pyrrolidine-2,3-dione chemical structure, C23H15BrN2O5, CAS 339255-89-9
(4E)-1-(4-Bromophenyl)-4-[hydroxy(phenyl)methylidene]-5-(3-nitrophenyl)pyrrolidine-2,3-dione
CAS 339255-89-9C23H15BrN2O5
(4E)-4-[Hydroxy(phenyl)methylidene]-5-(3-nitrophenyl)-1-[3-(trifluoromethyl)phenyl]pyrrolidine-2,3-dione chemical structure, C24H15F3N2O5, CAS 331751-26-9
(4E)-4-[Hydroxy(phenyl)methylidene]-5-(3-nitrophenyl)-1-[3-(trifluoromethyl)phenyl]pyrrolidine-2,3-dione
CAS 331751-26-9C24H15F3N2O5
(4E)-1-(4-Acetylphenyl)-4-[(4-chlorophenyl)-hydroxymethylidene]-5-(4-methoxyphenyl)pyrrolidine-2,3-dione chemical structure, C26H20ClNO5, CAS 331751-38-3
(4E)-1-(4-Acetylphenyl)-4-[(4-chlorophenyl)-hydroxymethylidene]-5-(4-methoxyphenyl)pyrrolidine-2,3-dione
CAS 331751-38-3C26H20ClNO5
(4E)-1-(3-Bromophenyl)-4-[hydroxy(phenyl)methylidene]-5-(2-methoxyphenyl)pyrrolidine-2,3-dione chemical structure, C24H18BrNO4, CAS 489396-89-6
(4E)-1-(3-Bromophenyl)-4-[hydroxy(phenyl)methylidene]-5-(2-methoxyphenyl)pyrrolidine-2,3-dione
CAS 489396-89-6C24H18BrNO4
(4E)-1-(3-Chloro-4-methylphenyl)-4-[hydroxy(phenyl)methylidene]-5-(4-methylphenyl)pyrrolidine-2,3-dione chemical structure, C25H20ClNO3, CAS 799839-92-2
(4E)-1-(3-Chloro-4-methylphenyl)-4-[hydroxy(phenyl)methylidene]-5-(4-methylphenyl)pyrrolidine-2,3-dione
CAS 799839-92-2C25H20ClNO3
(4E)-4-[(4-Chlorophenyl)-hydroxymethylidene]-5-(4-fluorophenyl)-1-(4-methoxyphenyl)pyrrolidine-2,3-dione chemical structure, C24H17ClFNO4, CAS 425413-18-9
(4E)-4-[(4-Chlorophenyl)-hydroxymethylidene]-5-(4-fluorophenyl)-1-(4-methoxyphenyl)pyrrolidine-2,3-dione
CAS 425413-18-9C24H17ClFNO4
(4E)-1-(4-Ethoxyphenyl)-5-(4-fluorophenyl)-4-[hydroxy(phenyl)methylidene]pyrrolidine-2,3-dione chemical structure, C25H20FNO4, CAS 331751-25-8
(4E)-1-(4-Ethoxyphenyl)-5-(4-fluorophenyl)-4-[hydroxy(phenyl)methylidene]pyrrolidine-2,3-dione
CAS 331751-25-8C25H20FNO4
(4E)-1-(3-Bromophenyl)-4-[hydroxy(phenyl)methylidene]-5-phenylpyrrolidine-2,3-dione chemical structure, C23H16BrNO3, CAS 423743-66-2
(4E)-1-(3-Bromophenyl)-4-[hydroxy(phenyl)methylidene]-5-phenylpyrrolidine-2,3-dione
CAS 423743-66-2C23H16BrNO3
(4E)-4-[Hydroxy(phenyl)methylidene]-1-(4-methoxyphenyl)-5-(4-nitrophenyl)pyrrolidine-2,3-dione chemical structure, C24H18N2O6, CAS 425611-14-9
(4E)-4-[Hydroxy(phenyl)methylidene]-1-(4-methoxyphenyl)-5-(4-nitrophenyl)pyrrolidine-2,3-dione
CAS 425611-14-9C24H18N2O6
(4E)-5-(4-Bromophenyl)-4-[hydroxy(phenyl)methylidene]-1-phenylpyrrolidine-2,3-dione chemical structure, C23H16BrNO3, CAS 331751-15-6
(4E)-5-(4-Bromophenyl)-4-[hydroxy(phenyl)methylidene]-1-phenylpyrrolidine-2,3-dione
CAS 331751-15-6C23H16BrNO3
4-Benzoyl-3-hydroxy-5-(4-methoxyphenyl)-1-phenyl-1H-pyrrol-2(5H)-one chemical structure, C24H19NO4, CAS 331751-21-4
4-Benzoyl-3-hydroxy-5-(4-methoxyphenyl)-1-phenyl-1H-pyrrol-2(5H)-one
CAS 331751-21-4C24H19NO4
(4E)-5-(3,4-Dimethoxyphenyl)-4-[hydroxy(phenyl)methylidene]-1-[3-(trifluoromethyl)phenyl]pyrrolidine-2,3-dione chemical structure, C26H20F3NO5, CAS 423743-79-7
(4E)-5-(3,4-Dimethoxyphenyl)-4-[hydroxy(phenyl)methylidene]-1-[3-(trifluoromethyl)phenyl]pyrrolidine-2,3-dione
CAS 423743-79-7C26H20F3NO5