Murcko scaffold
Ring system with 4 rings and 27 atoms
373 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 27
- Chemicals
- 373
- With full pages
- 10
Scaffold SMILES
O=c1c(S(=O)(=O)c2ccccc2)cn(Cc2ccccc2)c2ccccc12
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 373 chemicals
![6-Methoxy-3-(4-methylbenzenesulfonyl)-1-[(2-methylphenyl)methyl]-1,4-dihydroquinolin-4-one chemical structure, C25H23NO4S, CAS 902298-69-5](/s/ZWXZQOVNJUOKPF-UHFFFAOYSA-N.svg)
6-Methoxy-3-(4-methylbenzenesulfonyl)-1-[(2-methylphenyl)methyl]-1,4-dihydroquinolin-4-one
CAS 902298-69-5C25H23NO4S
6-Ethoxy-1-(3-methylbenzyl)-3-tosylquinolin-4(1H)-one
CAS 866340-34-3C26H25NO4S
![6-Methoxy-1-[(3-methoxyphenyl)methyl]-3-(4-methylbenzenesulfonyl)-1,4-dihydroquinolin-4-one chemical structure, C25H23NO5S, CAS 902299-02-9](/s/MAPVLQOKSDYFJI-UHFFFAOYSA-N.svg)
6-Methoxy-1-[(3-methoxyphenyl)methyl]-3-(4-methylbenzenesulfonyl)-1,4-dihydroquinolin-4-one
CAS 902299-02-9C25H23NO5S
1-Benzyl-3-(4-ethoxybenzenesulfonyl)-6-methoxy-1,4-dihydroquinolin-4-one
CAS 866340-35-4C25H23NO5S
1-Benzyl-6-ethoxy-3-(4-ethoxyphenyl)sulfonylquinolin-4-one
CAS 866340-36-5C26H25NO5S
![3-(4-Ethoxyphenyl)sulfonyl-6-methoxy-1-[(2-methylphenyl)methyl]quinolin-4-one chemical structure, C26H25NO5S, CAS 866340-37-6](/s/XNZAXFQTHAVOPR-UHFFFAOYSA-N.svg)
3-(4-Ethoxyphenyl)sulfonyl-6-methoxy-1-[(2-methylphenyl)methyl]quinolin-4-one
CAS 866340-37-6C26H25NO5S
![6-Ethoxy-3-(4-ethoxyphenyl)sulfonyl-1-[(2-methylphenyl)methyl]quinolin-4-one chemical structure, C27H27NO5S, CAS 866340-38-7](/s/FFAYKHBDIZHPBE-UHFFFAOYSA-N.svg)
6-Ethoxy-3-(4-ethoxyphenyl)sulfonyl-1-[(2-methylphenyl)methyl]quinolin-4-one
CAS 866340-38-7C27H27NO5S
![3-(4-Ethoxyphenyl)sulfonyl-6-methoxy-1-[(3-methylphenyl)methyl]quinolin-4-one chemical structure, C26H25NO5S, CAS 866340-39-8](/s/KPQMWZHRORCKFL-UHFFFAOYSA-N.svg)
3-(4-Ethoxyphenyl)sulfonyl-6-methoxy-1-[(3-methylphenyl)methyl]quinolin-4-one
CAS 866340-39-8C26H25NO5S
![6-Ethoxy-3-(4-ethoxyphenyl)sulfonyl-1-[(3-methylphenyl)methyl]quinolin-4-one chemical structure, C27H27NO5S, CAS 866340-40-1](/s/FIXVXMCUQCQBNB-UHFFFAOYSA-N.svg)
6-Ethoxy-3-(4-ethoxyphenyl)sulfonyl-1-[(3-methylphenyl)methyl]quinolin-4-one
CAS 866340-40-1C27H27NO5S
![3-(4-Ethoxyphenyl)sulfonyl-6-methoxy-1-[(4-methylphenyl)methyl]quinolin-4-one chemical structure, C26H25NO5S, CAS 866340-41-2](/s/MJLAGQAYEAVLGC-UHFFFAOYSA-N.svg)
3-(4-Ethoxyphenyl)sulfonyl-6-methoxy-1-[(4-methylphenyl)methyl]quinolin-4-one
CAS 866340-41-2C26H25NO5S
![6-Ethoxy-3-(4-ethoxyphenyl)sulfonyl-1-[(4-methylphenyl)methyl]quinolin-4-one chemical structure, C27H27NO5S, CAS 866340-42-3](/s/INAPEELPMINYTJ-UHFFFAOYSA-N.svg)
6-Ethoxy-3-(4-ethoxyphenyl)sulfonyl-1-[(4-methylphenyl)methyl]quinolin-4-one
CAS 866340-42-3C27H27NO5S
![1-[(2-Chlorophenyl)methyl]-3-(4-ethoxyphenyl)sulfonyl-6-methoxyquinolin-4-one chemical structure, C25H22ClNO5S, CAS 866340-43-4](/s/TVZFUIIQDZEMES-UHFFFAOYSA-N.svg)
1-[(2-Chlorophenyl)methyl]-3-(4-ethoxyphenyl)sulfonyl-6-methoxyquinolin-4-one
CAS 866340-43-4C25H22ClNO5S
![1-[(2-Chlorophenyl)methyl]-6-ethoxy-3-(4-ethoxyphenyl)sulfonylquinolin-4-one chemical structure, C26H24ClNO5S, CAS 866340-44-5](/s/NYJPNBZWTLPKTE-UHFFFAOYSA-N.svg)
1-[(2-Chlorophenyl)methyl]-6-ethoxy-3-(4-ethoxyphenyl)sulfonylquinolin-4-one
CAS 866340-44-5C26H24ClNO5S
![1-[(3-Chlorophenyl)methyl]-3-(4-ethoxyphenyl)sulfonyl-6-methoxyquinolin-4-one chemical structure, C25H22ClNO5S, CAS 866340-45-6](/s/ZFPUYRZFQNUYSE-UHFFFAOYSA-N.svg)
1-[(3-Chlorophenyl)methyl]-3-(4-ethoxyphenyl)sulfonyl-6-methoxyquinolin-4-one
CAS 866340-45-6C25H22ClNO5S
![1-[(3-Chlorophenyl)methyl]-6-ethoxy-3-(4-ethoxybenzenesulfonyl)-1,4-dihydroquinolin-4-one chemical structure, C26H24ClNO5S, CAS 866340-46-7](/s/GXUNYSABHIQOLP-UHFFFAOYSA-N.svg)
1-[(3-Chlorophenyl)methyl]-6-ethoxy-3-(4-ethoxybenzenesulfonyl)-1,4-dihydroquinolin-4-one
CAS 866340-46-7C26H24ClNO5S
![1-[(4-Chlorophenyl)methyl]-3-(4-ethoxyphenyl)sulfonyl-6-methoxyquinolin-4-one chemical structure, C25H22ClNO5S, CAS 866340-47-8](/s/ARARKCYQOPEOFT-UHFFFAOYSA-N.svg)
1-[(4-Chlorophenyl)methyl]-3-(4-ethoxyphenyl)sulfonyl-6-methoxyquinolin-4-one
CAS 866340-47-8C25H22ClNO5S
![1-[(4-Chlorophenyl)methyl]-6-ethoxy-3-(4-ethoxyphenyl)sulfonylquinolin-4-one chemical structure, C26H24ClNO5S, CAS 866340-48-9](/s/CMONPXLLGMXPQY-UHFFFAOYSA-N.svg)
1-[(4-Chlorophenyl)methyl]-6-ethoxy-3-(4-ethoxyphenyl)sulfonylquinolin-4-one
CAS 866340-48-9C26H24ClNO5S
![3-(4-Ethoxyphenyl)sulfonyl-1-[(2-fluorophenyl)methyl]-6-methoxyquinolin-4-one chemical structure, C25H22FNO5S, CAS 866340-49-0](/s/WSABEBVCHMBTHU-UHFFFAOYSA-N.svg)
3-(4-Ethoxyphenyl)sulfonyl-1-[(2-fluorophenyl)methyl]-6-methoxyquinolin-4-one
CAS 866340-49-0C25H22FNO5S
![6-Ethoxy-3-(4-ethoxyphenyl)sulfonyl-1-[(2-fluorophenyl)methyl]quinolin-4-one chemical structure, C26H24FNO5S, CAS 866340-50-3](/s/YISUDLBNDRMHQL-UHFFFAOYSA-N.svg)
6-Ethoxy-3-(4-ethoxyphenyl)sulfonyl-1-[(2-fluorophenyl)methyl]quinolin-4-one
CAS 866340-50-3C26H24FNO5S
![3-(4-Ethoxyphenyl)sulfonyl-1-[(3-fluorophenyl)methyl]-6-methoxyquinolin-4-one chemical structure, C25H22FNO5S, CAS 866340-51-4](/s/RWWGPKHWXCEYGL-UHFFFAOYSA-N.svg)
3-(4-Ethoxyphenyl)sulfonyl-1-[(3-fluorophenyl)methyl]-6-methoxyquinolin-4-one
CAS 866340-51-4C25H22FNO5S
![6-Ethoxy-3-(4-ethoxyphenyl)sulfonyl-1-[(3-fluorophenyl)methyl]quinolin-4-one chemical structure, C26H24FNO5S, CAS 866340-52-5](/s/VGVRVEPHSAMPBT-UHFFFAOYSA-N.svg)
6-Ethoxy-3-(4-ethoxyphenyl)sulfonyl-1-[(3-fluorophenyl)methyl]quinolin-4-one
CAS 866340-52-5C26H24FNO5S
![3-(4-Ethoxyphenyl)sulfonyl-1-[(4-fluorophenyl)methyl]-6-methoxyquinolin-4-one chemical structure, C25H22FNO5S, CAS 866340-53-6](/s/RZYUTQMNEJFFKN-UHFFFAOYSA-N.svg)
3-(4-Ethoxyphenyl)sulfonyl-1-[(4-fluorophenyl)methyl]-6-methoxyquinolin-4-one
CAS 866340-53-6C25H22FNO5S
![6-Ethoxy-3-(4-ethoxyphenyl)sulfonyl-1-[(4-fluorophenyl)methyl]quinolin-4-one chemical structure, C26H24FNO5S, CAS 866340-54-7](/s/LBZGHJKAWHHVSH-UHFFFAOYSA-N.svg)
6-Ethoxy-3-(4-ethoxyphenyl)sulfonyl-1-[(4-fluorophenyl)methyl]quinolin-4-one
CAS 866340-54-7C26H24FNO5S
![3-(4-Ethoxybenzenesulfonyl)-6-methoxy-1-[(3-methoxyphenyl)methyl]-1,4-dihydroquinolin-4-one chemical structure, C26H25NO6S, CAS 866340-55-8](/s/OBPVMDSWYBDJRU-UHFFFAOYSA-N.svg)
3-(4-Ethoxybenzenesulfonyl)-6-methoxy-1-[(3-methoxyphenyl)methyl]-1,4-dihydroquinolin-4-one
CAS 866340-55-8C26H25NO6S
- 6-Ethoxy-3-(4-ethoxyphenyl)sulfonyl-1-[(3-methoxyphenyl)methyl]quinolin-4-one866340-56-9C27H27NO6S
- 3-(4-Ethoxybenzenesulfonyl)-6-methoxy-1-[(4-methoxyphenyl)methyl]-1,4-dihydroquinolin-4-one866340-57-0C26H25NO6S
- 6-Ethoxy-3-(4-ethoxyphenyl)sulfonyl-1-[(4-methoxyphenyl)methyl]quinolin-4-one866340-58-1C27H27NO6S
- 1-[(2,5-Dimethylphenyl)methyl]-3-(4-ethoxyphenyl)sulfonyl-6-methoxyquinolin-4-one866340-59-2C27H27NO5S
- 1-[(2,5-Dimethylphenyl)methyl]-6-ethoxy-3-(4-ethoxybenzenesulfonyl)-1,4-dihydroquinolin-4-one866340-60-5C28H29NO5S
- 3-(Benzenesulfonyl)-1-benzyl-6-methoxy-1,4-dihydroquinolin-4-one866725-71-5C23H19NO4S
- 3-(Benzenesulfonyl)-1-benzyl-6-ethoxy-1,4-dihydroquinolin-4-one866725-72-6C24H21NO4S
- 3-(Benzenesulfonyl)-1-benzyl-6,7-dimethoxy-1,4-dihydroquinolin-4-one866725-73-7C24H21NO5S
- 3-(Benzenesulfonyl)-1-benzyl-6-fluoroquinolin-4-one866725-74-8C22H16FNO3S
- 3-(Benzenesulfonyl)-6-methoxy-1-[(2-methylphenyl)methyl]quinolin-4-one866725-75-9C24H21NO4S
- 3-(Benzenesulfonyl)-6-ethoxy-1-[(2-methylphenyl)methyl]quinolin-4-one866725-76-0C25H23NO4S
- 3-(Benzenesulfonyl)-6,7-dimethoxy-1-[(2-methylphenyl)methyl]quinolin-4-one866725-77-1C25H23NO5S
- 3-(Benzenesulfonyl)-6-fluoro-1-[(2-methylphenyl)methyl]-1,4-dihydroquinolin-4-one866725-78-2C23H18FNO3S
- 3-(Benzenesulfonyl)-6-methoxy-1-[(3-methylphenyl)methyl]quinolin-4-one866725-79-3C24H21NO4S
- 3-(Benzenesulfonyl)-6-ethoxy-1-[(3-methylphenyl)methyl]-1,4-dihydroquinolin-4-one866725-81-7C25H23NO4S
- 3-(Benzenesulfonyl)-6,7-dimethoxy-1-[(3-methylphenyl)methyl]-1,4-dihydroquinolin-4-one866725-82-8C25H23NO5S
- 3-(Benzenesulfonyl)-6-fluoro-1-[(3-methylphenyl)methyl]-1,4-dihydroquinolin-4-one866725-83-9C23H18FNO3S
- 3-(Benzenesulfonyl)-6-methoxy-1-[(4-methylphenyl)methyl]quinolin-4-one866725-84-0C24H21NO4S
- 3-(Benzenesulfonyl)-6-ethoxy-1-[(4-methylphenyl)methyl]quinolin-4-one866725-85-1C25H23NO4S
- 3-(Benzenesulfonyl)-6,7-dimethoxy-1-[(4-methylphenyl)methyl]quinolin-4-one866725-86-2C25H23NO5S
- 3-(Benzenesulfonyl)-6-fluoro-1-[(4-methylphenyl)methyl]quinolin-4-one866725-87-3C23H18FNO3S
- 1-(2-Chlorobenzyl)-6-methoxy-3-(phenylsulfonyl)quinolin-4(1H)-one866725-88-4C23H18ClNO4S
- 1-(2-Chlorobenzyl)-6-ethoxy-3-(phenylsulfonyl)quinolin-4(1H)-one866725-89-5C24H20ClNO4S
- 3-(Benzenesulfonyl)-1-[(2-chlorophenyl)methyl]-6,7-dimethoxyquinolin-4-one866725-90-8C24H20ClNO5S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(c1ccccc1)c1cn(Cc2ccccc2)c2ccccc2c1=O5 chemicals
O=C(c1ccccc1)c1cn(Cc2ccccc2)c2ncccc2c1=O2 chemicals
O=c1c2ccccc2n(Cc2ccccc2)c(=O)n1Cc1ccccc12 chemicals
O=c1c2cccnc2n(Cc2ccccc2)c(=O)n1Cc1ccccc12 chemicals
c1ccc(Cc2cc3ccccc3c(Cc3ccccc3)n2)cc11 chemical![Scaffold O=c1[nH]ncc2cc(NC3CCCCC3)nc(Nc3ccccc3)c12](/scaffold/CGGOQPZORGBMKQ-UHFFFAOYSA-N/structure.svg)
O=c1[nH]ncc2cc(NC3CCCCC3)nc(Nc3ccccc3)c121 chemical
O=C(c1cc(Nc2ccccc2)c2ccccc2n1)N1CCCCC11 chemical
c1ccc(Nc2cc(Nc3ccccc3)c3ccccc3c2)cc11 chemical
c1ccc(Nc2nc(Nc3ccccc3)c3ccccc3n2)cc11 chemical
O=c1c2ccccc2n(Cc2ccccc2)c(=O)n1CC1CCCCC11 chemical