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Murcko scaffold

Ring system with 3 rings and 16 atoms

28 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
28
With full pages
3
Scaffold SMILES

c1ccc(Oc2cccc3c2CCC3)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Oc2cccc3c2CCC3)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

4-Methyl-7-[2-nitro-4-(trifluoromethyl)phenoxy]-2,3-dihydro-1H-indene chemical structure, C17H14F3NO3, CAS 303009-96-3
4-Methyl-7-[2-nitro-4-(trifluoromethyl)phenoxy]-2,3-dihydro-1H-indene
CAS 303009-96-3C17H14F3NO3
2-Chloro-N-[2-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-5-(trifluoromethyl)phenyl]acetamide chemical structure, C19H17ClF3NO2, CAS 303010-43-7
2-Chloro-N-[2-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-5-(trifluoromethyl)phenyl]acetamide
CAS 303010-43-7C19H17ClF3NO2
2-[4-[(7-Hydroxy-2,3-dihydro-1H-inden-4-yl)oxy]-3,5-dimethylanilino]-2-oxoacetic acid chemical structure, C19H19NO5, CAS 290352-28-2
2-[4-[(7-Hydroxy-2,3-dihydro-1H-inden-4-yl)oxy]-3,5-dimethylanilino]-2-oxoacetic acid
CAS 290352-28-2C19H19NO5
3-[[7-(4-Hydroxy-3-propan-2-ylphenoxy)-6-methyl-2,3-dihydro-1H-inden-4-yl]amino]-3-oxopropanoic acid chemical structure, C22H25NO5, CAS 575503-70-7
3-[[7-(4-Hydroxy-3-propan-2-ylphenoxy)-6-methyl-2,3-dihydro-1H-inden-4-yl]amino]-3-oxopropanoic acid
CAS 575503-70-7C22H25NO5
1-Butanesulfonic acid, 4,4,4-trifluoro-, 3-(((2R)-2,3-dihydro-2-(hydroxymethyl)-1H-inden-4-yl)oxy)phenyl ester chemical structure, C20H21F3O5S, CAS 212188-60-8
1-Butanesulfonic acid, 4,4,4-trifluoro-, 3-(((2R)-2,3-dihydro-2-(hydroxymethyl)-1H-inden-4-yl)oxy)phenyl ester
CAS 212188-60-8C20H21F3O5S
4-Phenoxy-2,3-dihydro-1H-indene-1-carbonitrile chemical structure, C16H13NO, CAS 62850-30-0
4-Phenoxy-2,3-dihydro-1H-indene-1-carbonitrile
CAS 62850-30-0C16H13NO
4-(4-Methylphenoxy)-2,3-dihydro-1H-indene-1-carbonitrile chemical structure, C17H15NO, CAS 62803-61-6
4-(4-Methylphenoxy)-2,3-dihydro-1H-indene-1-carbonitrile
CAS 62803-61-6C17H15NO
N-Hydroxy-N-(4-phenoxy-2,3-dihydro-1H-inden-1-yl)urea chemical structure, C16H16N2O3, CAS 138910-83-5
N-Hydroxy-N-(4-phenoxy-2,3-dihydro-1H-inden-1-yl)urea
CAS 138910-83-5C16H16N2O3
4-(4-Methoxyphenoxy)-5-methyl-7-nitroindane chemical structure, C17H17NO4, CAS 575504-35-7
4-(4-Methoxyphenoxy)-5-methyl-7-nitroindane
CAS 575504-35-7C17H17NO4
RefChem:177079 chemical structure, C17H10F5NO4S, CAS 1672662-14-4
RefChem:177079
CAS 1672662-14-4C17H10F5NO4S
PT-2385 chemical structure, C17H12F3NO4S, CAS 1672665-49-4
PT-2385
CAS 1672665-49-4C17H12F3NO4S
PT-2385 (R enantiomer) chemical structure, C17H12F3NO4S, CAS 1672666-67-9
PT-2385 (R enantiomer)
CAS 1672666-67-9C17H12F3NO4S
Belzutifan impurity 2 chemical structure, C17H12F3NO4S, CAS 1672668-51-7
Belzutifan impurity 2
CAS 1672668-51-7C17H12F3NO4S
(Rac)-PT2399 chemical structure, C17H10F5NO4S, CAS 1672662-07-5
(Rac)-PT2399
CAS 1672662-07-5C17H10F5NO4S
HS4KN28Ddk chemical structure, C17H11F4NO4S, CAS 1672668-35-7
HS4KN28Ddk
CAS 1672668-35-7C17H11F4NO4S
Belzutifan chemical structure, C17H12F3NO4S, CAS 1672668-24-4
Belzutifan
CAS 1672668-24-4C17H12F3NO4S
Zus5ynu7R3 chemical structure, C17H13F2NO4S, CAS 1672668-52-8
Zus5ynu7R3
CAS 1672668-52-8C17H13F2NO4S
HIF-2alpha-IN-2 chemical structure, C17H13F2NO4S, CAS 1672666-82-8
HIF-2alpha-IN-2
CAS 1672666-82-8C17H13F2NO4S
3-Fluoro-5-(((1S,2R)-2-fluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile chemical structure, C17H13F2NO4S, CAS 1672666-80-6
3-Fluoro-5-(((1S,2R)-2-fluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile
CAS 1672666-80-6C17H13F2NO4S
(1S,2R,3S)-4-(3-Cyano-5-fluorophenoxy)-2-fluoro-3-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-1-yl acetate chemical structure, C19H15F2NO6S, CAS 1672668-28-8
(1S,2R,3S)-4-(3-Cyano-5-fluorophenoxy)-2-fluoro-3-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-1-yl acetate
CAS 1672668-28-8C19H15F2NO6S
(1S,2R,3R)-4-(3-Cyano-5-fluorophenoxy)-2-fluoro-3-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-1-yl acetate chemical structure, C19H15F2NO6S, CAS 1672668-29-9
(1S,2R,3R)-4-(3-Cyano-5-fluorophenoxy)-2-fluoro-3-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-1-yl acetate
CAS 1672668-29-9C19H15F2NO6S
(1S,2S,3S)-4-(3-Cyano-5-fluorophenoxy)-2,3-difluoro-7-(methylsulfonyl)-2,3-dihydro-1H-inden-1-yl acetate chemical structure, C19H14F3NO5S, CAS 2365402-28-2
(1S,2S,3S)-4-(3-Cyano-5-fluorophenoxy)-2,3-difluoro-7-(methylsulfonyl)-2,3-dihydro-1H-inden-1-yl acetate
CAS 2365402-28-2C19H14F3NO5S
3-Fluoro-5-(((1S,2R,3S)-2-fluoro-1,3-dihydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile chemical structure, C17H13F2NO5S, CAS 2738675-99-3
3-Fluoro-5-(((1S,2R,3S)-2-fluoro-1,3-dihydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile
CAS 2738675-99-3C17H13F2NO5S
Benzonitrile, 3-(((1S,2R)-1-(acetyloxy)-2-fluoro-2,3-dihydro-7-(methylsulfonyl)-1H-inden-4-yl)oxy)-5-fluoro- chemical structure, C19H15F2NO5S, CAS 1672668-25-5
Benzonitrile, 3-(((1S,2R)-1-(acetyloxy)-2-fluoro-2,3-dihydro-7-(methylsulfonyl)-1H-inden-4-yl)oxy)-5-fluoro-
CAS 1672668-25-5C19H15F2NO5S