Murcko scaffold
2-Phenacylsulfanyl-1H-quinazolin-4-one scaffold
69 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 21
- Chemicals
- 69
- With full pages
- 9
Scaffold SMILES
O=C(CSc1nc2ccccc2c(=O)[nH]1)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=C(CSc1nc2ccccc2c(=O)[nH]1)c1ccccc1](/scaffold/LLAHCLJNKMLHCQ-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 69 chemicals
![2-[2-(4-Ethylphenyl)-2-oxoethyl]sulfanyl-3-methylquinazolin-4-one chemical structure, C19H18N2O2S, CAS 312522-34-2](/s/WMGMHESHCJQFRQ-UHFFFAOYSA-N.svg)
2-[2-(4-Ethylphenyl)-2-oxoethyl]sulfanyl-3-methylquinazolin-4-one
CAS 312522-34-2C19H18N2O2S
![3-Amino-2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-4(3H)-quinazolinone chemical structure, C16H12ClN3O2S, CAS 78045-82-6](/s/SQOJKYVBHKHTJU-UHFFFAOYSA-N.svg)
3-Amino-2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-4(3H)-quinazolinone
CAS 78045-82-6C16H12ClN3O2S
3-Ethyl-2-((2-oxo-2-phenylethyl)thio)quinazolin-4(3H)-one
CAS 324578-69-0C18H16N2O2S
2-Phenacylsulfanyl-3-prop-2-enylquinazolin-4-one
CAS 224630-70-0C19H16N2O2S
![2-[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl-3-methylquinazolin-4-one chemical structure, C17H13ClN2O2S, CAS 316358-80-2](/s/NYMLMXFSLZJSRQ-UHFFFAOYSA-N.svg)
2-[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl-3-methylquinazolin-4-one
CAS 316358-80-2C17H13ClN2O2S
3-Methyl-2-phenacylsulfanylquinazolin-4-one
CAS 557069-91-7C17H14N2O2S
![2-{[2-(3-Methoxyphenyl)-2-oxoethyl]sulfanyl}-3-(2-methylpropyl)-3,4-dihydroquinazolin-4-one chemical structure, C21H22N2O3S, CAS 255865-17-9](/s/LZPRDYFDAWAJBH-UHFFFAOYSA-N.svg)
2-{[2-(3-Methoxyphenyl)-2-oxoethyl]sulfanyl}-3-(2-methylpropyl)-3,4-dihydroquinazolin-4-one
CAS 255865-17-9C21H22N2O3S
2-((2-(4-Bromophenyl)-2-oxoethyl)sulfanyl)-3-isobutyl-4(3H)-quinazolinone
CAS 255865-18-0C20H19BrN2O2S
![2-{[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl}-3-ethyl-4(3H)-quinazolinone chemical structure, C18H15ClN2O2S, CAS 327167-70-4](/s/POTZYZPRYJDONS-UHFFFAOYSA-N.svg)
2-{[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl}-3-ethyl-4(3H)-quinazolinone
CAS 327167-70-4C18H15ClN2O2S
![2-{[2-(3,4-Dichlorophenyl)-2-oxoethyl]sulfanyl}-3-ethyl-3,4-dihydroquinazolin-4-one chemical structure, C18H14Cl2N2O2S, CAS 329080-29-7](/s/MTQVEYDTVBFUJZ-UHFFFAOYSA-N.svg)
2-{[2-(3,4-Dichlorophenyl)-2-oxoethyl]sulfanyl}-3-ethyl-3,4-dihydroquinazolin-4-one
CAS 329080-29-7C18H14Cl2N2O2S
3-Allyl-2-((2-(4-chlorophenyl)-2-oxoethyl)thio)quinazolin-4(3H)-one
CAS 224630-73-3C19H15ClN2O2S
2-((2-(4-Chlorophenyl)-2-oxoethyl)thio)-3-isobutyl-4(3H)-quinazolinone
CAS 255865-16-8C20H19ClN2O2S
![2-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-3-methylquinazolin-4-one chemical structure, C17H13BrN2O2S, CAS 331972-17-9](/s/BHECTUCSZDMFCW-UHFFFAOYSA-N.svg)
2-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-3-methylquinazolin-4-one
CAS 331972-17-9C17H13BrN2O2S
![2-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-3-prop-2-enylquinazolin-4-one chemical structure, C19H15BrN2O2S, CAS 53278-77-6](/s/YNRDWGXBRVTPFG-UHFFFAOYSA-N.svg)
2-[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl-3-prop-2-enylquinazolin-4-one
CAS 53278-77-6C19H15BrN2O2S
![2-[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl-6-iodo-3-prop-2-enylquinazolin-4-one chemical structure, C19H14ClIN2O2S, CAS 488121-20-6](/s/MFLHZIUOOMBDAZ-UHFFFAOYSA-N.svg)
2-[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl-6-iodo-3-prop-2-enylquinazolin-4-one
CAS 488121-20-6C19H14ClIN2O2S
3-Ethyl-6-iodo-2-phenacylsulfanylquinazolin-4-one
CAS 714280-70-3C18H15IN2O2S
6-Iodo-3-(2-methylprop-2-enyl)-2-phenacylsulfanylquinazolin-4-one
CAS 488717-29-9C20H17IN2O2S
3-Allyl-2-((2-(2-fluoro-4-methoxyphenyl)-2-oxoethyl)thio)quinazolin-4(3H)-one
CAS 325995-69-5C20H17FN2O3S
3-Allyl-2-((2-(3-nitrophenyl)-2-oxoethyl)thio)quinazolin-4(3H)-one
CAS 313395-97-0C19H15N3O4S
![Methyl 2-[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl-3-(2-methoxyethyl)-4-oxoquinazoline-7-carboxylate chemical structure, C21H19ClN2O5S, CAS 403729-03-3](/s/GIMNBQOBLORVNI-UHFFFAOYSA-N.svg)
Methyl 2-[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl-3-(2-methoxyethyl)-4-oxoquinazoline-7-carboxylate
CAS 403729-03-3C21H19ClN2O5S
Methyl 3-(2-methoxyethyl)-4-oxo-2-phenacylsulfanylquinazoline-7-carboxylate
CAS 422273-83-4C21H20N2O5S
![2-{[2-(2,4-Dimethylphenyl)-2-oxoethyl]sulfanyl}-N-(2-methoxyethyl)-3-(3-methylbutyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide chemical structure, C27H33N3O4S, CAS 1021224-58-7](/s/YSRNKWNVIKZBQL-UHFFFAOYSA-N.svg)
2-{[2-(2,4-Dimethylphenyl)-2-oxoethyl]sulfanyl}-N-(2-methoxyethyl)-3-(3-methylbutyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide
CAS 1021224-58-7C27H33N3O4S
![N-(2-Methoxyethyl)-2-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-3-(3-methylbutyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide chemical structure, C26H31N3O5S, CAS 1021261-65-3](/s/OAFNMQIGSCGCLY-UHFFFAOYSA-N.svg)
N-(2-Methoxyethyl)-2-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-3-(3-methylbutyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide
CAS 1021261-65-3C26H31N3O5S
2-((2-(4-Chlorophenyl)-2-oxoethyl)thio)-N-isobutyl-3-(2-methoxyethyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide
CAS 1021262-17-8C24H26ClN3O4S
- 2-{[2-(4-Ethoxyphenyl)-2-oxoethyl]sulfanyl}-N,3-bis(2-methoxyethyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide946323-30-4C25H29N3O6S
- 2-((2-(3,4-Dimethoxyphenyl)-2-oxoethyl)thio)-N-isopropyl-3-(2-methoxyethyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide932513-02-5C25H29N3O6S
- 2-((2-(4-Fluorophenyl)-2-oxoethyl)thio)-N-isobutyl-3-(2-methoxyethyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide946269-36-9C24H26FN3O4S
- 2-((2-(4-Ethoxyphenyl)-2-oxoethyl)thio)-N-isobutyl-3-(2-methoxyethyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide946385-29-1C26H31N3O5S
- N-Isopentyl-3-(2-methoxyethyl)-2-((2-(4-methoxyphenyl)-2-oxoethyl)thio)-4-oxo-3,4-dihydroquinazoline-7-carboxamide946324-22-7C26H31N3O5S
- 2-((2-(3,4-Dimethoxyphenyl)-2-oxoethyl)thio)-3-isobutyl-N-isopropyl-4-oxo-3,4-dihydroquinazoline-7-carboxamide946386-02-3C26H31N3O5S
- 2-((2-(4-Ethoxyphenyl)-2-oxoethyl)thio)-3-isobutyl-N-isopropyl-4-oxo-3,4-dihydroquinazoline-7-carboxamide946270-27-5C26H31N3O4S
- 2-{[2-(4-Methoxyphenyl)-2-oxoethyl]sulfanyl}-N,3-bis(2-methylpropyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide946236-58-4C26H31N3O4S
- 2-((2-(4-Fluorophenyl)-2-oxoethyl)thio)-3-isobutyl-N-(2-methoxyethyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide946237-56-5C24H26FN3O4S
- 2-((2-(4-Bromophenyl)-2-oxoethyl)thio)-N-isopropyl-3-(2-methoxyethyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide932351-23-0C23H24BrN3O4S
- 2-((2-(2,5-Dimethylphenyl)-2-oxoethyl)thio)-3-isobutyl-4-oxo-N-propyl-3,4-dihydroquinazoline-7-carboxamide1113141-87-9C26H31N3O3S
- 2-{[2-(4-Fluorophenyl)-2-oxoethyl]sulfanyl}-N-(3-methylbutyl)-3-(2-methylpropyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide1113134-63-6C26H30FN3O3S
- 2-{[2-(4-Methoxyphenyl)-2-oxoethyl]sulfanyl}-N-(3-methylbutyl)-3-(2-methylpropyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide1113134-68-1C27H33N3O4S
- 2-{[2-(2,4-Dimethylphenyl)-2-oxoethyl]sulfanyl}-N-(3-methylbutyl)-3-(2-methylpropyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide1113132-26-5C28H35N3O3S
- 2-((2-(4-Bromophenyl)-2-oxoethyl)thio)-N,3-diisobutyl-4-oxo-3,4-dihydroquinazoline-7-carboxamide932319-76-1C25H28BrN3O3S
- 2-((2-(4-Chlorophenyl)-2-oxoethyl)thio)-N,3-diisobutyl-4-oxo-3,4-dihydroquinazoline-7-carboxamide1207660-11-4C25H28ClN3O3S
- 2-{[2-(4-Methylphenyl)-2-oxoethyl]sulfanyl}-N,3-bis(2-methylpropyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide1113135-18-4C26H31N3O3S
- 2-((2-(3,4-Dimethoxyphenyl)-2-oxoethyl)thio)-3-isopentyl-4-oxo-N-propyl-3,4-dihydroquinazoline-7-carboxamide1113139-47-1C27H33N3O5S
- 2-((2-(4-Ethoxyphenyl)-2-oxoethyl)thio)-3-isopentyl-N-(2-methoxyethyl)-4-oxo-3,4-dihydroquinazoline-7-carboxamide1113136-50-7C27H33N3O5S
- 3-Isopentyl-N-isopropyl-4-oxo-2-((2-oxo-2-(p-tolyl)ethyl)thio)-3,4-dihydroquinazoline-7-carboxamide1113139-67-5C26H31N3O3S
- 2-((2-(2,4-Dimethylphenyl)-2-oxoethyl)thio)-3-isopentyl-N-isopropyl-4-oxo-3,4-dihydroquinazoline-7-carboxamide1113136-62-1C27H33N3O3S
- 2-((2-(2,5-Dimethylphenyl)-2-oxoethyl)thio)-3-isopentyl-N-isopropyl-4-oxo-3,4-dihydroquinazoline-7-carboxamide1113139-72-2C27H33N3O3S
- 2-((2-(3,4-Dimethoxyphenyl)-2-oxoethyl)thio)-3-isopentyl-N-isopropyl-4-oxo-3,4-dihydroquinazoline-7-carboxamide1113136-68-7C27H33N3O5S
- N-Isobutyl-3-isopentyl-4-oxo-2-((2-oxo-2-phenylethyl)thio)-3,4-dihydroquinazoline-7-carboxamide1113137-04-4C26H31N3O3S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(CC1Nc2ccccc2NC1=O)Nc1ccccc153 chemicals
O=C(CC1Sc2ccccc2NC1=O)Nc1ccccc153 chemicals
O=C(Cn1cnc2ccccc2c1=O)Nc1ccccc149 chemicals![Scaffold O=C(NCc1ccccc1)c1cc2ccccc2[nH]c1=O](/scaffold/NFZNYXLYBOKFMQ-UHFFFAOYSA-N/structure.svg)
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O=C(CN1CCc2ccccc2C1)Nc1ccccc117 chemicals
O=C(COc1ccccc1)N1CCc2ccccc2C116 chemicals
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