Murcko scaffold
Ring system with 2 rings and 19 atoms
37 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 19
- Chemicals
- 37
- With full pages
- 12
Scaffold SMILES
O=C(NCCSCc1ccccc1)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 37 of 37 chemicals
Ethyl 2-benzamido-3-benzylsulfanyl-3-methyl-butanoate
CAS 5448-25-9C21H25NO3S
Methyl 2-benzamido-3-benzylsulfanyl-3-methylbutanoate
CAS 75323-54-5C20H23NO3S
![N-{2-[(Mesitylmethyl)sulfanyl]-2-methylpropyl}-3-nitrobenzenecarboxamide chemical structure, C21H26N2O3S, CAS 338962-62-2](/s/ZJENFHXZUJSIBP-UHFFFAOYSA-N.svg)
N-{2-[(Mesitylmethyl)sulfanyl]-2-methylpropyl}-3-nitrobenzenecarboxamide
CAS 338962-62-2C21H26N2O3S
![N-{2-[(Mesitylmethyl)sulfanyl]-2-methylpropyl}-4-methoxybenzenecarboxamide chemical structure, C22H29NO2S, CAS 338962-66-6](/s/MZKUXKSKMRVVSK-UHFFFAOYSA-N.svg)
N-{2-[(Mesitylmethyl)sulfanyl]-2-methylpropyl}-4-methoxybenzenecarboxamide
CAS 338962-66-6C22H29NO2S
![N-{2-[(4-Fluorobenzyl)sulfanyl]-2-methylpropyl}-3-methoxybenzenecarboxamide chemical structure, C19H22FNO2S, CAS 477845-56-0](/s/MYILYJNQYVXWMD-UHFFFAOYSA-N.svg)
N-{2-[(4-Fluorobenzyl)sulfanyl]-2-methylpropyl}-3-methoxybenzenecarboxamide
CAS 477845-56-0C19H22FNO2S
![2,6-Dichloro-N-{2-[(4-fluorobenzyl)sulfanyl]-2-methylpropyl}benzenecarboxamide chemical structure, C18H18Cl2FNOS, CAS 478245-97-5](/s/FUNSNRZGPJEJDC-UHFFFAOYSA-N.svg)
2,6-Dichloro-N-{2-[(4-fluorobenzyl)sulfanyl]-2-methylpropyl}benzenecarboxamide
CAS 478245-97-5C18H18Cl2FNOS
![N-{2-[(4-Fluorobenzyl)sulfanyl]-2-methylpropyl}-3-nitrobenzenecarboxamide chemical structure, C18H19FN2O3S, CAS 351858-11-2](/s/GKXZLWHXYHTMIX-UHFFFAOYSA-N.svg)
N-{2-[(4-Fluorobenzyl)sulfanyl]-2-methylpropyl}-3-nitrobenzenecarboxamide
CAS 351858-11-2C18H19FN2O3S
![4-Fluoro-N-{2-[(4-fluorobenzyl)sulfanyl]-2-methylpropyl}benzenecarboxamide chemical structure, C18H19F2NOS, CAS 478246-00-3](/s/QONLHCWXHXEUEW-UHFFFAOYSA-N.svg)
4-Fluoro-N-{2-[(4-fluorobenzyl)sulfanyl]-2-methylpropyl}benzenecarboxamide
CAS 478246-00-3C18H19F2NOS
![N-{2-[(4-Chlorobenzyl)sulfanyl]-2-methylpropyl}benzenecarboxamide chemical structure, C18H20ClNOS, CAS 303144-65-2](/s/RKMAQBYCKNSAAK-UHFFFAOYSA-N.svg)
N-{2-[(4-Chlorobenzyl)sulfanyl]-2-methylpropyl}benzenecarboxamide
CAS 303144-65-2C18H20ClNOS
![N-[2-[(4-Chlorophenyl)methylsulfanyl]ethyl]-2-methyl-3-nitrobenzamide chemical structure, C17H17ClN2O3S, CAS 333413-59-5](/s/DPLJHQUMEDBERP-UHFFFAOYSA-N.svg)
N-[2-[(4-Chlorophenyl)methylsulfanyl]ethyl]-2-methyl-3-nitrobenzamide
CAS 333413-59-5C17H17ClN2O3S
![2,4-Dichloro-N-[2-[(2,4-dichlorophenyl)methylsulfanyl]ethyl]benzamide chemical structure, C16H13Cl4NOS, CAS 431927-59-2](/s/JPZLZHGDCPFIFD-UHFFFAOYSA-N.svg)
2,4-Dichloro-N-[2-[(2,4-dichlorophenyl)methylsulfanyl]ethyl]benzamide
CAS 431927-59-2C16H13Cl4NOS
![4-Bromo-N-{2-[(2-chlorobenzyl)sulfanyl]ethyl}benzamide chemical structure, C16H15BrClNOS, CAS 367913-99-3](/s/COQPCDSKCJHCSY-UHFFFAOYSA-N.svg)
4-Bromo-N-{2-[(2-chlorobenzyl)sulfanyl]ethyl}benzamide
CAS 367913-99-3C16H15BrClNOS
![N-{2-[(3,4-Dichlorobenzyl)sulfanyl]ethyl}-3,5-dimethoxybenzamide chemical structure, C18H19Cl2NO3S, CAS 723739-72-8](/s/IOJUHCMKLRZJLB-UHFFFAOYSA-N.svg)
N-{2-[(3,4-Dichlorobenzyl)sulfanyl]ethyl}-3,5-dimethoxybenzamide
CAS 723739-72-8C18H19Cl2NO3S
![4-tert-Butyl-N-{2-[(2-methylbenzyl)sulfanyl]ethyl}benzamide chemical structure, C21H27NOS, CAS 530138-73-9](/s/VWHYTNDIUMPPJF-UHFFFAOYSA-N.svg)
4-tert-Butyl-N-{2-[(2-methylbenzyl)sulfanyl]ethyl}benzamide
CAS 530138-73-9C21H27NOS
![N-{2-[(2-Methylbenzyl)sulfanyl]ethyl}-4-nitrobenzamide chemical structure, C17H18N2O3S, CAS 530093-41-5](/s/UJGHZSKVUOZJJZ-UHFFFAOYSA-N.svg)
N-{2-[(2-Methylbenzyl)sulfanyl]ethyl}-4-nitrobenzamide
CAS 530093-41-5C17H18N2O3S
![N-{2-[(2-Methylbenzyl)sulfanyl]ethyl}benzamide chemical structure, C17H19NOS, CAS 530152-90-0](/s/JCLKDLKHXZMXQW-UHFFFAOYSA-N.svg)
N-{2-[(2-Methylbenzyl)sulfanyl]ethyl}benzamide
CAS 530152-90-0C17H19NOS
![N-[2-[(2,6-Dichlorophenyl)methylsulfanyl]ethyl]-4-methoxybenzamide chemical structure, C17H17Cl2NO2S, CAS 531546-70-0](/s/MEQTYFZFIQAMOS-UHFFFAOYSA-N.svg)
N-[2-[(2,6-Dichlorophenyl)methylsulfanyl]ethyl]-4-methoxybenzamide
CAS 531546-70-0C17H17Cl2NO2S
![2-Methoxy-N-{2-[(4-methylbenzyl)sulfanyl]ethyl}benzamide chemical structure, C18H21NO2S, CAS 694485-44-4](/s/XDVYQBYYYNFTOO-UHFFFAOYSA-N.svg)
2-Methoxy-N-{2-[(4-methylbenzyl)sulfanyl]ethyl}benzamide
CAS 694485-44-4C18H21NO2S
![N-[2-[(4-Chlorophenyl)methylsulfanyl]ethyl]-3,5-dimethoxybenzamide chemical structure, C18H20ClNO3S, CAS 643005-10-1](/s/BHRXCJUTACLIIL-UHFFFAOYSA-N.svg)
N-[2-[(4-Chlorophenyl)methylsulfanyl]ethyl]-3,5-dimethoxybenzamide
CAS 643005-10-1C18H20ClNO3S
![N-{2-[(2-Chloro-6-fluorobenzyl)sulfanyl]ethyl}-2-methoxybenzamide chemical structure, C17H17ClFNO2S, CAS 694496-94-1](/s/DNSOQSPEPSMKGA-UHFFFAOYSA-N.svg)
N-{2-[(2-Chloro-6-fluorobenzyl)sulfanyl]ethyl}-2-methoxybenzamide
CAS 694496-94-1C17H17ClFNO2S
![N-{2-[(3-Chlorobenzyl)sulfanyl]ethyl}-2-methyl-3-nitrobenzamide chemical structure, C17H17ClN2O3S, CAS 695169-92-7](/s/ZACMWTKZPBGOJW-UHFFFAOYSA-N.svg)
N-{2-[(3-Chlorobenzyl)sulfanyl]ethyl}-2-methyl-3-nitrobenzamide
CAS 695169-92-7C17H17ClN2O3S
![N-{2-[(3-Chlorobenzyl)sulfanyl]ethyl}-4-fluorobenzamide chemical structure, C16H15ClFNOS, CAS 700860-27-1](/s/JSAVEDRWFJKFEU-UHFFFAOYSA-N.svg)
N-{2-[(3-Chlorobenzyl)sulfanyl]ethyl}-4-fluorobenzamide
CAS 700860-27-1C16H15ClFNOS
![2-Chloro-N-{2-[(4-chlorobenzyl)sulfanyl]ethyl}benzamide chemical structure, C16H15Cl2NOS, CAS 367931-15-5](/s/ZXQFQQZOISUVEM-UHFFFAOYSA-N.svg)
2-Chloro-N-{2-[(4-chlorobenzyl)sulfanyl]ethyl}benzamide
CAS 367931-15-5C16H15Cl2NOS
![N-{2-[(4-Methylbenzyl)sulfanyl]ethyl}-3-nitrobenzamide chemical structure, C17H18N2O3S, CAS 367933-17-3](/s/KFROFNUQUPQKGS-UHFFFAOYSA-N.svg)
N-{2-[(4-Methylbenzyl)sulfanyl]ethyl}-3-nitrobenzamide
CAS 367933-17-3C17H18N2O3S
- 4-Chloro-N-{2-[(3,4-dichlorobenzyl)sulfanyl]ethyl}-3-nitrobenzamide431908-27-9C16H13Cl3N2O3S
- N-[2-[(2,4-Dichlorophenyl)methylsulfanyl]ethyl]-4-methoxybenzamide431938-23-7C17H17Cl2NO2S
- N-{2-[(4-Chlorobenzyl)sulfanyl]ethyl}benzamide428491-53-6C16H16ClNOS
- N-[2-[(3-Chlorophenyl)methylsulfanyl]ethyl]-3,4-dimethoxybenzamide332419-80-4C18H20ClNO3S
- 4-Methoxy-N-{2-[(4-methylbenzyl)sulfanyl]ethyl}benzamide367912-78-5C18H21NO2S
- N-[2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]ethyl]-4-(methanesulfonamido)benzamide831232-51-0C17H18ClFN2O3S2
- N-[2-[(2-Chlorophenyl)methylsulfanyl]ethyl]-2-methyl-3-nitrobenzamide335212-17-4C17H17ClN2O3S
- 2-Benzamido-3-benzylsulfanyl-3-methylbutanoic acid5398-45-8C19H21NO3S
- 2,5-Dichloro-N-{2-[(mesitylmethyl)sulfanyl]-2-methylpropyl}benzenecarboxamide338962-65-5C21H25Cl2NOS
- N-{2-[(Mesitylmethyl)sulfanyl]-2-methylpropyl}-2-(trifluoromethyl)benzenecarboxamide343372-98-5C22H26F3NOS
- 3,4-Dichloro-N-[2-methyl-2-[[3-(trifluoromethyl)phenyl]methylsulfanyl]propyl]benzamide339104-44-8C19H18Cl2F3NOS
- N-{2-[(4-Chlorobenzyl)sulfanyl]ethyl}-3,4-dimethoxybenzamide425667-17-0C18H20ClNO3S
- N-(2-Methyl-2-{[3-(trifluoromethyl)benzyl]sulfanyl}propyl)-4-nitrobenzenecarboxamide882747-84-4C19H19F3N2O3S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(COc1ccccc1)NN=Cc1ccccc1255 chemicals
O=C(NN=Cc1ccccc1)C(=O)Nc1ccccc1251 chemicals
O=C(NCNC(=S)Nc1ccccc1)c1ccccc179 chemicals
O=C(C=Cc1ccccc1)NCCc1ccccc145 chemicals
O=C(NCCc1ccccc1)OCc1ccccc142 chemicals
O=C(CCc1ccccc1)NCCc1ccccc138 chemicals
c1ccc(CCCNCCc2ccccc2)cc138 chemicals
O=C(CNc1ccccc1)NN=Cc1ccccc126 chemicals
O=S(=O)(NC=NCCc1ccccc1)c1ccccc126 chemicals
c1ccc(CCNCCOc2ccccc2)cc126 chemicals
O=C(CCCOc1ccccc1)Nc1ccccc121 chemicals
O=C(COc1ccccc1)NCCc1ccccc120 chemicals