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Murcko scaffold

Ring system with 2 rings and 19 atoms

18 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
19
Chemicals
18
With full pages
8
Scaffold SMILES

O=C(CCC(=O)Nc1nncs1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCC(=O)Nc1nncs1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

N1-(2,5-dimethoxyphenyl)-N4-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)succinamide chemical structure, C15H15F3N4O4S, CAS 714937-13-0
N1-(2,5-dimethoxyphenyl)-N4-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)succinamide
CAS 714937-13-0C15H15F3N4O4S
Succinamide, N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-N'-p-tolyl- chemical structure, C16H20N4O2S, CAS 107811-37-0
Succinamide, N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-N'-p-tolyl-
CAS 107811-37-0C16H20N4O2S
N'-(5-Ethyl-1,3,4-thiadiazol-2-yl)-N-(4-methylphenyl)butanediamide chemical structure, C15H18N4O2S, CAS 714928-34-4
N'-(5-Ethyl-1,3,4-thiadiazol-2-yl)-N-(4-methylphenyl)butanediamide
CAS 714928-34-4C15H18N4O2S
N1-(3-chloro-4-methoxyphenyl)-N4-(5-isobutyl-1,3,4-thiadiazol-2-yl)succinamide chemical structure, C17H21ClN4O3S, CAS 713127-48-1
N1-(3-chloro-4-methoxyphenyl)-N4-(5-isobutyl-1,3,4-thiadiazol-2-yl)succinamide
CAS 713127-48-1C17H21ClN4O3S
N1-(5-isobutyl-1,3,4-thiadiazol-2-yl)-N4-(2-isopropylphenyl)succinamide chemical structure, C19H26N4O2S, CAS 713128-39-3
N1-(5-isobutyl-1,3,4-thiadiazol-2-yl)-N4-(2-isopropylphenyl)succinamide
CAS 713128-39-3C19H26N4O2S
Succinamide, N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-N'-phenyl- chemical structure, C15H18N4O2S, CAS 107811-36-9
Succinamide, N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-N'-phenyl-
CAS 107811-36-9C15H18N4O2S
N1-(4-isopropylphenyl)-N4-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)succinamide chemical structure, C16H17F3N4O2S, CAS 714253-08-4
N1-(4-isopropylphenyl)-N4-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)succinamide
CAS 714253-08-4C16H17F3N4O2S
N1-(4-bromophenyl)-N4-(5-propyl-1,3,4-thiadiazol-2-yl)succinamide chemical structure, C15H17BrN4O2S, CAS 714253-41-5
N1-(4-bromophenyl)-N4-(5-propyl-1,3,4-thiadiazol-2-yl)succinamide
CAS 714253-41-5C15H17BrN4O2S
N1-(4-chloro-2-methoxy-5-methylphenyl)-N4-(5-propyl-1,3,4-thiadiazol-2-yl)succinamide chemical structure, C17H21ClN4O3S, CAS 714919-43-4
N1-(4-chloro-2-methoxy-5-methylphenyl)-N4-(5-propyl-1,3,4-thiadiazol-2-yl)succinamide
CAS 714919-43-4C17H21ClN4O3S
Succinamide, N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-N'-m-tolyl- chemical structure, C16H20N4O2S, CAS 107811-38-1
Succinamide, N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-N'-m-tolyl-
CAS 107811-38-1C16H20N4O2S
N1-(4-bromo-3-methylphenyl)-N4-(5-propyl-1,3,4-thiadiazol-2-yl)succinamide chemical structure, C16H19BrN4O2S, CAS 713088-36-9
N1-(4-bromo-3-methylphenyl)-N4-(5-propyl-1,3,4-thiadiazol-2-yl)succinamide
CAS 713088-36-9C16H19BrN4O2S
N-(2-Methoxy-5-methyl-phenyl)-N'-(5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)-succinamide chemical structure, C15H15F3N4O3S, CAS 714932-60-2
N-(2-Methoxy-5-methyl-phenyl)-N'-(5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)-succinamide
CAS 714932-60-2C15H15F3N4O3S
N-(2-Fluorophenyl)-N'-[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]butanediamide chemical structure, C16H19FN4O2S, CAS 714939-03-4
N-(2-Fluorophenyl)-N'-[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]butanediamide
CAS 714939-03-4C16H19FN4O2S
Succinamide, N-(p-chlorophenyl)-N'-(5-isopropyl-1,3,4-thiadiazol-2-yl)- chemical structure, C15H17ClN4O2S, CAS 107811-39-2
Succinamide, N-(p-chlorophenyl)-N'-(5-isopropyl-1,3,4-thiadiazol-2-yl)-
CAS 107811-39-2C15H17ClN4O2S
N1-(4-bromophenyl)-N4-(5-ethyl-1,3,4-thiadiazol-2-yl)succinamide chemical structure, C14H15BrN4O2S, CAS 444798-74-7
N1-(4-bromophenyl)-N4-(5-ethyl-1,3,4-thiadiazol-2-yl)succinamide
CAS 444798-74-7C14H15BrN4O2S
N1-(5-isopropyl-1,3,4-thiadiazol-2-yl)-N4-(3-(trifluoromethyl)phenyl)succinamide chemical structure, C16H17F3N4O2S, CAS 714943-82-5
N1-(5-isopropyl-1,3,4-thiadiazol-2-yl)-N4-(3-(trifluoromethyl)phenyl)succinamide
CAS 714943-82-5C16H17F3N4O2S
N1-(4-bromo-3-methylphenyl)-N4-(5-isopropyl-1,3,4-thiadiazol-2-yl)succinamide chemical structure, C16H19BrN4O2S, CAS 714949-14-1
N1-(4-bromo-3-methylphenyl)-N4-(5-isopropyl-1,3,4-thiadiazol-2-yl)succinamide
CAS 714949-14-1C16H19BrN4O2S
Succinamide, N-(p-bromophenyl)-N'-(5-isopropyl-1,3,4-thiadiazol-2-yl)- chemical structure, C15H17BrN4O2S, CAS 107811-40-5
Succinamide, N-(p-bromophenyl)-N'-(5-isopropyl-1,3,4-thiadiazol-2-yl)-
CAS 107811-40-5C15H17BrN4O2S