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Murcko scaffold

Ring system with 5 rings and 30 atoms

4 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
30
Chemicals
4
With full pages
1
Scaffold SMILES

c1ccc(COc2ccc(Nc3ncnc4ccc(-c5cscn5)cc34)cc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(COc2ccc(Nc3ncnc4ccc(-c5cscn5)cc34)cc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 4 of 4 chemicals

6-Thiazolylquinazoline 5 chemical structure, C28H26ClN5O3S2, CAS 552334-84-6
6-Thiazolylquinazoline 5
CAS 552334-84-6C28H26ClN5O3S2
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[(2-methylsulfonylethylamino)methyl]-1,3-thiazol-4-yl]quinazolin-4-amine chemical structure, C28H25ClFN5O3S2, CAS 388082-81-3
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[(2-methylsulfonylethylamino)methyl]-1,3-thiazol-4-yl]quinazolin-4-amine
CAS 388082-81-3C28H25ClFN5O3S2
GW 583340 chemical structure, C28H27Cl3FN5O3S2, CAS 1173023-85-2
GW 583340
CAS 1173023-85-2C28H27Cl3FN5O3S2
N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(2-(((2-(methylsulfonyl)ethyl)amino)methyl)thiazol-4-yl)quinazolin-4-amine hydrochloride chemical structure, C28H26Cl2FN5O3S2, CAS 443883-12-3
N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(2-(((2-(methylsulfonyl)ethyl)amino)methyl)thiazol-4-yl)quinazolin-4-amine hydrochloride
CAS 443883-12-3C28H26Cl2FN5O3S2