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Murcko scaffold

Ring system with 2 rings and 18 atoms

224 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 18
Chemicals: 224
With full pages: 4

Scaffold SMILES

O=C(C=Cc1ccccc1)NCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(C=Cc1ccccc1)NCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 224 chemicals

3-(4-Isopropylphenyl)-N-(4-methylbenzyl)acrylamide chemical structure, C20H23NO, CAS 544451-04-9

3-(4-Isopropylphenyl)-N-(4-methylbenzyl)acrylamide

CAS 544451-04-9C₂₀H₂₃NO

(E)-3-(2-Nitrophenyl)-N-[(4-sulfamoylphenyl)methyl]prop-2-enamide chemical structure, C16H15N3O5S, CAS 600123-71-5

(E)-3-(2-Nitrophenyl)-N-[(4-sulfamoylphenyl)methyl]prop-2-enamide

CAS 600123-71-5C₁₆H₁₅N₃O₅S

(E)-N-Benzyl-N-tert-butyl-3-phenylprop-2-enamide chemical structure, C20H23NO, CAS 637034-43-6

(E)-N-Benzyl-N-tert-butyl-3-phenylprop-2-enamide

CAS 637034-43-6C₂₀H₂₃NO

(E)-N-[(2-Methoxyphenyl)methyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide chemical structure, C20H23NO5, CAS 432497-60-4

(E)-N-[(2-Methoxyphenyl)methyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide

CAS 432497-60-4C₂₀H₂₃NO₅

(2E)-N-Benzyl-3-(5-bromo-2,4-dimethoxyphenyl)-2-cyanoprop-2-enamide chemical structure, C19H17BrN2O3, CAS 6024-07-3

(2E)-N-Benzyl-3-(5-bromo-2,4-dimethoxyphenyl)-2-cyanoprop-2-enamide

CAS 6024-07-3C₁₉H₁₇BrN₂O₃

(E)-2-Cyano-3-(4-nitrophenyl)-N-[(1R)-1-phenylethyl]prop-2-enamide chemical structure, C18H15N3O3, CAS 857064-42-7

(E)-2-Cyano-3-(4-nitrophenyl)-N-[(1R)-1-phenylethyl]prop-2-enamide

CAS 857064-42-7C₁₈H₁₅N₃O₃

(E)-3-Phenyl-N-(4-phenylhepta-1,6-dien-4-yl)prop-2-enamide chemical structure, C22H23NO, CAS 307338-94-9

(E)-3-Phenyl-N-(4-phenylhepta-1,6-dien-4-yl)prop-2-enamide

CAS 307338-94-9C₂₂H₂₃NO

(E)-3-(2,6-Dichlorophenyl)-N-[(3,4-dichlorophenyl)methyl]prop-2-enamide chemical structure, C16H11Cl4NO, CAS 544432-05-5

(E)-3-(2,6-Dichlorophenyl)-N-[(3,4-dichlorophenyl)methyl]prop-2-enamide

CAS 544432-05-5C₁₆H₁₁Cl₄NO

N-Benzyl-2-cyano-3-(2-nitrophenyl)prop-2-enamide chemical structure, C17H13N3O3, CAS 121217-56-9

N-Benzyl-2-cyano-3-(2-nitrophenyl)prop-2-enamide

CAS 121217-56-9C₁₇H₁₃N₃O₃

(E)-2-Acetamido-N-benzyl-3-phenylacrylamide chemical structure, C18H18N2O2, CAS 55636-11-8

(E)-2-Acetamido-N-benzyl-3-phenylacrylamide

CAS 55636-11-8C₁₈H₁₈N₂O₂

4-[(1Z)-3-(Benzylamino)-2-cyano-3-oxoprop-1-en-1-yl]benzoic acid chemical structure, C18H14N2O3, CAS 1164519-24-7

4-[(1Z)-3-(Benzylamino)-2-cyano-3-oxoprop-1-en-1-yl]benzoic acid

CAS 1164519-24-7C₁₈H₁₄N₂O₃

(E)-3-(3-Nitrophenyl)-N-[(4-sulfamoylphenyl)methyl]prop-2-enamide chemical structure, C16H15N3O5S, CAS 349434-16-8

(E)-3-(3-Nitrophenyl)-N-[(4-sulfamoylphenyl)methyl]prop-2-enamide

CAS 349434-16-8C₁₆H₁₅N₃O₅S

3-(3-Bromophenyl)-N-(4-fluorobenzyl)acrylamide chemical structure, C16H13BrFNO, CAS 647031-69-4

3-(3-Bromophenyl)-N-(4-fluorobenzyl)acrylamide

CAS 647031-69-4C₁₆H₁₃BrFNO

(E)-N-[(4-Fluorophenyl)methyl]-3-(4-methylsulfanylphenyl)prop-2-enamide chemical structure, C17H16FNOS, CAS 882748-97-2

(E)-N-[(4-Fluorophenyl)methyl]-3-(4-methylsulfanylphenyl)prop-2-enamide

CAS 882748-97-2C₁₇H₁₆FNOS

N-Benzyl-3-(3-bromophenyl)acrylamide chemical structure, C16H14BrNO, CAS 331462-16-9

N-Benzyl-3-(3-bromophenyl)acrylamide

CAS 331462-16-9C₁₆H₁₄BrNO

N-(4-Chlorobenzyl)-3-(3-nitrophenyl)acrylamide chemical structure, C16H13ClN2O3, CAS 331462-23-8

N-(4-Chlorobenzyl)-3-(3-nitrophenyl)acrylamide

CAS 331462-23-8C₁₆H₁₃ClN₂O₃

N-Benzyl-2-cyano-3-(4-hydroxy-3,5-dimethylphenyl)prop-2-enamide chemical structure, C19H18N2O2, CAS 519011-14-4

N-Benzyl-2-cyano-3-(4-hydroxy-3,5-dimethylphenyl)prop-2-enamide

CAS 519011-14-4C₁₉H₁₈N₂O₂

N-Benzyl-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-cyanoprop-2-enamide chemical structure, C18H15BrN2O3, CAS 345971-50-8

N-Benzyl-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-cyanoprop-2-enamide

CAS 345971-50-8C₁₈H₁₅BrN₂O₃

(E)-N-[(2-Methoxyphenyl)methyl]-3-(2-nitrophenyl)prop-2-enamide chemical structure, C17H16N2O4, CAS 524686-43-9

(E)-N-[(2-Methoxyphenyl)methyl]-3-(2-nitrophenyl)prop-2-enamide

CAS 524686-43-9C₁₇H₁₆N₂O₄

N-Benzyl-2-cyano-3-[4-(difluoromethoxy)phenyl]-N-methylprop-2-enamide chemical structure, C19H16F2N2O2, CAS 326185-65-3

N-Benzyl-2-cyano-3-[4-(difluoromethoxy)phenyl]-N-methylprop-2-enamide

CAS 326185-65-3C₁₉H₁₆F₂N₂O₂

N-Benzyl-2-cyano-3-(4-hydroxy-3-nitrophenyl)prop-2-enamide chemical structure, C17H13N3O4, CAS 340301-65-7

N-Benzyl-2-cyano-3-(4-hydroxy-3-nitrophenyl)prop-2-enamide

CAS 340301-65-7C₁₇H₁₃N₃O₄

N-[(4-Chlorophenyl)methyl]-2-cyano-3-[4-(3-methylbutoxy)phenyl]prop-2-enamide chemical structure, C22H23ClN2O2, CAS 475072-57-2

N-[(4-Chlorophenyl)methyl]-2-cyano-3-[4-(3-methylbutoxy)phenyl]prop-2-enamide

CAS 475072-57-2C₂₂H₂₃ClN₂O₂

3-(4-Chloro-3-nitrophenyl)-N-[(4-chlorophenyl)methyl]-2-cyanoprop-2-enamide chemical structure, C17H11Cl2N3O3, CAS 380493-73-2

3-(4-Chloro-3-nitrophenyl)-N-[(4-chlorophenyl)methyl]-2-cyanoprop-2-enamide

CAS 380493-73-2C₁₇H₁₁Cl₂N₃O₃

N-Benzyl-2-cyano-3-[2-(difluoromethoxy)phenyl]prop-2-enamide chemical structure, C18H14F2N2O2, CAS 380494-94-0

N-Benzyl-2-cyano-3-[2-(difluoromethoxy)phenyl]prop-2-enamide

CAS 380494-94-0C₁₈H₁₄F₂N₂O₂