CompoundList
Sign in
Murcko scaffold

4-Phenylisoquinolin-1(2H)-one scaffold

82 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
82
With full pages
3
Scaffold SMILES

O=c1[nH]cc(-c2ccccc2)c2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Phenylisoquinolin-1(2H)-one page
Murcko scaffold O=c1[nH]cc(-c2ccccc2)c2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 82 chemicals

N-[3-(Diethylamino)propyl]-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxamide chemical structure, C24H29N3O2, CAS 78945-87-6
N-[3-(Diethylamino)propyl]-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxamide
CAS 78945-87-6C24H29N3O2
4-[4-[Bis(2-chloroethyl)amino]phenyl]-2-(2-chloroethyl)isoquinolin-1-one chemical structure, C21H21Cl3N2O, CAS 64345-74-0
4-[4-[Bis(2-chloroethyl)amino]phenyl]-2-(2-chloroethyl)isoquinolin-1-one
CAS 64345-74-0C21H21Cl3N2O
3-Amino-2-methyl-7-nitro-4-phenylisoquinolin-1-one chemical structure, C16H13N3O3, CAS 136146-74-2
3-Amino-2-methyl-7-nitro-4-phenylisoquinolin-1-one
CAS 136146-74-2C16H13N3O3
3-Isoquinolinecarboxamide, 1,2-dihydro-N-(2-(dimethylamino)ethyl)-2-methyl-1-oxo-4-phenyl- chemical structure, C21H23N3O2, CAS 78945-90-1
3-Isoquinolinecarboxamide, 1,2-dihydro-N-(2-(dimethylamino)ethyl)-2-methyl-1-oxo-4-phenyl-
CAS 78945-90-1C21H23N3O2
3-Isoquinolinecarboxylic acid, 1,2-dihydro-2-(3-(diethylamino)propyl)-1-oxo-4-phenyl- chemical structure, C23H26N2O3, CAS 112392-92-4
3-Isoquinolinecarboxylic acid, 1,2-dihydro-2-(3-(diethylamino)propyl)-1-oxo-4-phenyl-
CAS 112392-92-4C23H26N2O3
3-Isoquinolinecarboxylic acid, 1,2-dihydro-2-(3-(dimethylamino)propyl)-1-oxo-4-phenyl- chemical structure, C21H22N2O3, CAS 112392-93-5
3-Isoquinolinecarboxylic acid, 1,2-dihydro-2-(3-(dimethylamino)propyl)-1-oxo-4-phenyl-
CAS 112392-93-5C21H22N2O3
3-Isoquinolinecarboxylic acid, 1,2-dihydro-2-(2-(diethylamino)ethyl)-1-oxo-4-phenyl- chemical structure, C22H24N2O3, CAS 112392-94-6
3-Isoquinolinecarboxylic acid, 1,2-dihydro-2-(2-(diethylamino)ethyl)-1-oxo-4-phenyl-
CAS 112392-94-6C22H24N2O3
3-Isoquinolinecarboxylic acid, 1,2-dihydro-2-(2-(dimethylamino)ethyl)-1-oxo-4-phenyl- chemical structure, C20H20N2O3, CAS 112392-95-7
3-Isoquinolinecarboxylic acid, 1,2-dihydro-2-(2-(dimethylamino)ethyl)-1-oxo-4-phenyl-
CAS 112392-95-7C20H20N2O3
2-Methyl-4-phenyl-1(2H)-isoquinolinone chemical structure, C16H13NO, CAS 108960-88-9
2-Methyl-4-phenyl-1(2H)-isoquinolinone
CAS 108960-88-9C16H13NO
RP 62420 chemical structure, C25H26FNO5, CAS 141267-40-5
RP 62420
CAS 141267-40-5C25H26FNO5
4-(4-((Dimethylamino)methyl)phenyl)-5-hydroxyisoquinolin-1(2H)-one chemical structure, C18H18N2O2, CAS 651029-09-3
4-(4-((Dimethylamino)methyl)phenyl)-5-hydroxyisoquinolin-1(2H)-one
CAS 651029-09-3C18H18N2O2
5-Hydroxy-4-(m-tolyl)isoquinolin-1(2H)-one chemical structure, C16H13NO2, CAS 656234-19-4
5-Hydroxy-4-(m-tolyl)isoquinolin-1(2H)-one
CAS 656234-19-4C16H13NO2
5-Hydroxy-4-phenylisoquinolin-1(2H)-one chemical structure, C15H11NO2, CAS 656234-16-1
5-Hydroxy-4-phenylisoquinolin-1(2H)-one
CAS 656234-16-1C15H11NO2
5-Hydroxy-4-(4-methoxyphenyl)isoquinolin-1(2H)-one chemical structure, C16H13NO3, CAS 656234-25-2
5-Hydroxy-4-(4-methoxyphenyl)isoquinolin-1(2H)-one
CAS 656234-25-2C16H13NO3
5-Hydroxy-4-(3,4,5-trihydroxyphenyl)isoquinolin-1(2H)-one chemical structure, C15H11NO5, CAS 656234-47-8
5-Hydroxy-4-(3,4,5-trihydroxyphenyl)isoquinolin-1(2H)-one
CAS 656234-47-8C15H11NO5
2-((3-(Aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-6-yl)oxy)acetamide chemical structure, C22H25N3O3, CAS 447416-95-7
2-((3-(Aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-6-yl)oxy)acetamide
CAS 447416-95-7C22H25N3O3
ISQ-1 HCl chemical structure, C20H23ClN2O2, CAS 405165-77-7
ISQ-1 HCl
CAS 405165-77-7C20H23ClN2O2
2-Fluoro-5-(5-hydroxy-1-oxo-1,2-dihydroisoquinolin-4-yl)benzaldehyde chemical structure, C16H10FNO3, CAS 656234-52-5
2-Fluoro-5-(5-hydroxy-1-oxo-1,2-dihydroisoquinolin-4-yl)benzaldehyde
CAS 656234-52-5C16H10FNO3
4-(3,4-Difluorophenyl)-5-hydroxyisoquinolin-1(2H)-one chemical structure, C15H9F2NO2, CAS 656234-23-0
4-(3,4-Difluorophenyl)-5-hydroxyisoquinolin-1(2H)-one
CAS 656234-23-0C15H9F2NO2
6-Methoxy-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbonitrile chemical structure, C17H12N2O2, CAS 849549-26-4
6-Methoxy-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbonitrile
CAS 849549-26-4C17H12N2O2
4-Phenylisoquinolin-1(2H)-one chemical structure, C15H11NO, CAS 36828-24-7
4-Phenylisoquinolin-1(2H)-one
CAS 36828-24-7C15H11NO
1-Oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid chemical structure, C16H11NO3, CAS 78945-99-0
1-Oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid
CAS 78945-99-0C16H11NO3
1-Oxo-4-phenyl-2-(propan-2-yl)-1,2-dihydroisoquinoline-3-carboxamide chemical structure, C19H18N2O2, CAS 134563-30-7
1-Oxo-4-phenyl-2-(propan-2-yl)-1,2-dihydroisoquinoline-3-carboxamide
CAS 134563-30-7C19H18N2O2
2-[[3-(Aminomethyl)-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl]oxy]acetamide hydrochloride chemical structure, C22H26ClN3O3, CAS 447416-94-6
2-[[3-(Aminomethyl)-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl]oxy]acetamide hydrochloride
CAS 447416-94-6C22H26ClN3O3