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Murcko scaffold

Ring system with 2 rings and 13 atoms

62 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
62
With full pages
12
Scaffold SMILES

C(=Cc1cc[nH]n1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C(=Cc1cc[nH]n1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 62 chemicals

5-Amino-3-[1-cyano-2-(3,5-dibromo-2-methoxyphenyl)ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile chemical structure, C16H13Br2N5O2, CAS 419544-69-7
5-Amino-3-[1-cyano-2-(3,5-dibromo-2-methoxyphenyl)ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile
CAS 419544-69-7C16H13Br2N5O2
5-Amino-3-[2-cyano-2-(2,4-dichlorophenyl)ethenyl]-1-(2-hydroxyethyl)-1H-pyrazole-4-carbonitrile chemical structure, C15H11Cl2N5O, CAS 400753-06-2
5-Amino-3-[2-cyano-2-(2,4-dichlorophenyl)ethenyl]-1-(2-hydroxyethyl)-1H-pyrazole-4-carbonitrile
CAS 400753-06-2C15H11Cl2N5O
5-Amino-3-(1-cyano-2-(3-iodo-5-methoxy-4-(prop-2-yn-1-yloxy)phenyl)vinyl)-1-(2-hydroxyethyl)-1H-pyrazole-4-carbonitrile chemical structure, C19H16IN5O3, CAS 328234-54-4
5-Amino-3-(1-cyano-2-(3-iodo-5-methoxy-4-(prop-2-yn-1-yloxy)phenyl)vinyl)-1-(2-hydroxyethyl)-1H-pyrazole-4-carbonitrile
CAS 328234-54-4C19H16IN5O3
3-Amino-5-[1-cyano-2-(4-ethoxy-3-methoxyphenyl)ethenyl]-1H-pyrazole-4-carbonitrile chemical structure, C16H15N5O2, CAS 5433-93-2
3-Amino-5-[1-cyano-2-(4-ethoxy-3-methoxyphenyl)ethenyl]-1H-pyrazole-4-carbonitrile
CAS 5433-93-2C16H15N5O2
5-Amino-3-[(Z)-1-cyano-2-(2-fluorophenyl)ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile chemical structure, C15H12FN5O, CAS 296770-53-1
5-Amino-3-[(Z)-1-cyano-2-(2-fluorophenyl)ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile
CAS 296770-53-1C15H12FN5O
5-Amino-3-[(Z)-2-(5-bromo-2-methoxyphenyl)-1-cyanoethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile chemical structure, C16H14BrN5O2, CAS 328071-40-5
5-Amino-3-[(Z)-2-(5-bromo-2-methoxyphenyl)-1-cyanoethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile
CAS 328071-40-5C16H14BrN5O2
5-Amino-3-[(Z)-2-(4-chlorophenyl)-1-cyanoethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile chemical structure, C15H12ClN5O, CAS 53871-39-9
5-Amino-3-[(Z)-2-(4-chlorophenyl)-1-cyanoethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile
CAS 53871-39-9C15H12ClN5O
5-Amino-3-[(Z)-2-(2-chlorophenyl)-1-cyanoethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile chemical structure, C15H12ClN5O, CAS 1066553-74-9
5-Amino-3-[(Z)-2-(2-chlorophenyl)-1-cyanoethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile
CAS 1066553-74-9C15H12ClN5O
5-Amino-3-[(Z)-1-cyano-2-(2,3-dimethoxyphenyl)ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile chemical structure, C17H17N5O3, CAS 347874-92-4
5-Amino-3-[(Z)-1-cyano-2-(2,3-dimethoxyphenyl)ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile
CAS 347874-92-4C17H17N5O3
N-[4-[(Z)-2-[5-Amino-4-cyano-1-(2-hydroxyethyl)pyrazol-3-yl]-2-cyanoethenyl]phenyl]acetamide chemical structure, C17H16N6O2, CAS 321742-07-8
N-[4-[(Z)-2-[5-Amino-4-cyano-1-(2-hydroxyethyl)pyrazol-3-yl]-2-cyanoethenyl]phenyl]acetamide
CAS 321742-07-8C17H16N6O2
5-Amino-3-[(Z)-2-(2-chloro-6-fluorophenyl)-1-cyanoethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile chemical structure, C15H11ClFN5O, CAS 328234-76-0
5-Amino-3-[(Z)-2-(2-chloro-6-fluorophenyl)-1-cyanoethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile
CAS 328234-76-0C15H11ClFN5O
5-Amino-3-[(Z)-1-cyano-2-(2,6-dichlorophenyl)ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile chemical structure, C15H11Cl2N5O, CAS 746604-46-6
5-Amino-3-[(Z)-1-cyano-2-(2,6-dichlorophenyl)ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile
CAS 746604-46-6C15H11Cl2N5O
Ethyl (4-{2-[5-amino-4-cyano-1-(2-hydroxyethyl)-1H-pyrazol-3-yl]-2-cyanovinyl}-2-bromo-6-ethoxyphenoxy)acetate chemical structure, C21H22BrN5O5, CAS 329742-40-7
Ethyl (4-{2-[5-amino-4-cyano-1-(2-hydroxyethyl)-1H-pyrazol-3-yl]-2-cyanovinyl}-2-bromo-6-ethoxyphenoxy)acetate
CAS 329742-40-7C21H22BrN5O5
5-Amino-3-[(Z)-1-cyano-2-(4-methylsulfanylphenyl)ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile chemical structure, C16H15N5OS, CAS 329686-26-2
5-Amino-3-[(Z)-1-cyano-2-(4-methylsulfanylphenyl)ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile
CAS 329686-26-2C16H15N5OS
5-Amino-3-[(Z)-1-cyano-2-[4-(diethylamino)phenyl]ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile chemical structure, C19H22N6O, CAS 328532-36-1
5-Amino-3-[(Z)-1-cyano-2-[4-(diethylamino)phenyl]ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile
CAS 328532-36-1C19H22N6O
Tyrphostin AG 568 chemical structure, C13H9N5O2, CAS 151013-48-8
Tyrphostin AG 568
CAS 151013-48-8C13H9N5O2
5-Amino-3-[(Z)-1-cyano-2-(4-methoxyphenyl)ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile chemical structure, C16H15N5O2, CAS 353514-46-2
5-Amino-3-[(Z)-1-cyano-2-(4-methoxyphenyl)ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile
CAS 353514-46-2C16H15N5O2
5-Amino-3-[(Z)-1-cyano-2-[2-(trifluoromethyl)phenyl]ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile chemical structure, C16H12F3N5O, CAS 321534-53-6
5-Amino-3-[(Z)-1-cyano-2-[2-(trifluoromethyl)phenyl]ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile
CAS 321534-53-6C16H12F3N5O
3-(4-Chlorostyryl)-1H-pyrazole chemical structure, C11H9ClN2, CAS 1829580-37-1
3-(4-Chlorostyryl)-1H-pyrazole
CAS 1829580-37-1C11H9ClN2
3-(2,6-Dichlorostyryl)-1H-pyrazole chemical structure, C11H8Cl2N2, CAS 1204318-68-2
3-(2,6-Dichlorostyryl)-1H-pyrazole
CAS 1204318-68-2C11H8Cl2N2
5-Amino-3-[(Z)-1-cyano-2-(3,4,5-trimethoxyphenyl)ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile chemical structure, C18H19N5O4, CAS 1321786-19-9
5-Amino-3-[(Z)-1-cyano-2-(3,4,5-trimethoxyphenyl)ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile
CAS 1321786-19-9C18H19N5O4
5-Amino-3-[(Z)-2-(4-bromo-3-nitrophenyl)-1-cyanoethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile chemical structure, C15H11BrN6O3, CAS 419545-18-9
5-Amino-3-[(Z)-2-(4-bromo-3-nitrophenyl)-1-cyanoethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile
CAS 419545-18-9C15H11BrN6O3
5-Amino-3-{1-cyano-2-[4-(dimethylamino)phenyl]vinyl}-1-(2-hydroxyethyl)-1H-pyrazole-4-carbonitrile chemical structure, C17H18N6O, CAS 419548-11-1
5-Amino-3-{1-cyano-2-[4-(dimethylamino)phenyl]vinyl}-1-(2-hydroxyethyl)-1H-pyrazole-4-carbonitrile
CAS 419548-11-1C17H18N6O
5-Amino-3-[(Z)-1-cyano-2-(3,4-dimethoxyphenyl)ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile chemical structure, C17H17N5O3, CAS 482281-01-6
5-Amino-3-[(Z)-1-cyano-2-(3,4-dimethoxyphenyl)ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile
CAS 482281-01-6C17H17N5O3