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Murcko scaffold

Ring system with 2 rings and 17 atoms

27 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
17
Chemicals
27
With full pages
6
Scaffold SMILES

O=C(C=Cc1ccccc1)NCC1CCCO1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)NCC1CCCO1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

2-[4-[2-Cyano-3-oxo-3-[[(tetrahydro-2-furanyl)methyl]amino]-1-propen-1-yl]-2-methoxyphenoxy]acetic acid chemical structure, C18H20N2O6, CAS 340319-09-7
2-[4-[2-Cyano-3-oxo-3-[[(tetrahydro-2-furanyl)methyl]amino]-1-propen-1-yl]-2-methoxyphenoxy]acetic acid
CAS 340319-09-7C18H20N2O6
3-(2,4-Dichlorophenyl)-N-(tetrahydro-2-furanylmethyl)acrylamide chemical structure, C14H15Cl2NO2, CAS 304890-18-4
3-(2,4-Dichlorophenyl)-N-(tetrahydro-2-furanylmethyl)acrylamide
CAS 304890-18-4C14H15Cl2NO2
2-Cyano-3-(4-hydroxyphenyl)-N-(tetrahydro-2-furanylmethyl)acrylamide chemical structure, C15H16N2O3, CAS 5867-77-6
2-Cyano-3-(4-hydroxyphenyl)-N-(tetrahydro-2-furanylmethyl)acrylamide
CAS 5867-77-6C15H16N2O3
3-(4-Chlorophenyl)-N-(tetrahydro-2-furanylmethyl)acrylamide chemical structure, C14H16ClNO2, CAS 324546-97-6
3-(4-Chlorophenyl)-N-(tetrahydro-2-furanylmethyl)acrylamide
CAS 324546-97-6C14H16ClNO2
2-Cyano-3-(4-hydroxy-3-methoxyphenyl)-N-[(oxolan-2-yl)methyl]prop-2-enamide chemical structure, C16H18N2O4, CAS 1164473-39-5
2-Cyano-3-(4-hydroxy-3-methoxyphenyl)-N-[(oxolan-2-yl)methyl]prop-2-enamide
CAS 1164473-39-5C16H18N2O4
(E)-2-Cyano-3-(3-ethoxy-4-hydroxyphenyl)-N-(oxolan-2-ylmethyl)prop-2-enamide chemical structure, C17H20N2O4, CAS 1164523-52-7
(E)-2-Cyano-3-(3-ethoxy-4-hydroxyphenyl)-N-(oxolan-2-ylmethyl)prop-2-enamide
CAS 1164523-52-7C17H20N2O4
3-(2,5-Dimethoxyphenyl)-N-(tetrahydro-2-furanylmethyl)acrylamide chemical structure, C16H21NO4, CAS 301681-89-0
3-(2,5-Dimethoxyphenyl)-N-(tetrahydro-2-furanylmethyl)acrylamide
CAS 301681-89-0C16H21NO4
(E)-3-(4-Nitrophenyl)-N-(oxolan-2-ylmethyl)prop-2-enamide chemical structure, C14H16N2O4, CAS 1164529-89-8
(E)-3-(4-Nitrophenyl)-N-(oxolan-2-ylmethyl)prop-2-enamide
CAS 1164529-89-8C14H16N2O4
(E)-3-(4-Fluorophenyl)-N-(oxolan-2-ylmethyl)prop-2-enamide chemical structure, C14H16FNO2, CAS 419553-77-8
(E)-3-(4-Fluorophenyl)-N-(oxolan-2-ylmethyl)prop-2-enamide
CAS 419553-77-8C14H16FNO2
(E)-3-(4-Methylphenyl)-N-(oxolan-2-ylmethyl)prop-2-enamide chemical structure, C15H19NO2, CAS 324562-47-2
(E)-3-(4-Methylphenyl)-N-(oxolan-2-ylmethyl)prop-2-enamide
CAS 324562-47-2C15H19NO2
Ethyl (4-{(1E)-2-cyano-3-oxo-3-[(tetrahydrofuran-2-ylmethyl)amino]prop-1-en-1-yl}-2-ethoxyphenoxy)acetate chemical structure, C21H26N2O6, CAS 340224-76-2
Ethyl (4-{(1E)-2-cyano-3-oxo-3-[(tetrahydrofuran-2-ylmethyl)amino]prop-1-en-1-yl}-2-ethoxyphenoxy)acetate
CAS 340224-76-2C21H26N2O6
(E)-N-(Oxolan-2-ylmethyl)-3-(3,4,5-trimethoxyphenyl)prop-2-enamide chemical structure, C17H23NO5, CAS 1360146-47-9
(E)-N-(Oxolan-2-ylmethyl)-3-(3,4,5-trimethoxyphenyl)prop-2-enamide
CAS 1360146-47-9C17H23NO5
(E)-N-(Oxolan-2-ylmethyl)-3-(4-propoxyphenyl)prop-2-enamide chemical structure, C17H23NO3, CAS 433952-99-9
(E)-N-(Oxolan-2-ylmethyl)-3-(4-propoxyphenyl)prop-2-enamide
CAS 433952-99-9C17H23NO3
(E)-3-(3,4-Dichlorophenyl)-N-(oxolan-2-ylmethyl)prop-2-enamide chemical structure, C14H15Cl2NO2, CAS 540790-36-1
(E)-3-(3,4-Dichlorophenyl)-N-(oxolan-2-ylmethyl)prop-2-enamide
CAS 540790-36-1C14H15Cl2NO2
(E)-3-(2-Nitrophenyl)-N-(oxolan-2-ylmethyl)prop-2-enamide chemical structure, C14H16N2O4, CAS 1164489-36-4
(E)-3-(2-Nitrophenyl)-N-(oxolan-2-ylmethyl)prop-2-enamide
CAS 1164489-36-4C14H16N2O4
(Z)-2-Acetamido-3-phenyl-N-((tetrahydrofuran-2-yl)methyl)acrylamide chemical structure, C16H20N2O3, CAS 308293-78-9
(Z)-2-Acetamido-3-phenyl-N-((tetrahydrofuran-2-yl)methyl)acrylamide
CAS 308293-78-9C16H20N2O3
2-Cyano-N-[(oxolan-2-yl)methyl]-3-phenylprop-2-enamide chemical structure, C15H16N2O2
2-Cyano-N-[(oxolan-2-yl)methyl]-3-phenylprop-2-enamide
C15H16N2O2
(E)-2-Cyano-N-(oxolan-2-ylmethyl)-3-[3-(trifluoromethyl)phenyl]prop-2-enamide chemical structure, C16H15F3N2O2, CAS 444182-55-2
(E)-2-Cyano-N-(oxolan-2-ylmethyl)-3-[3-(trifluoromethyl)phenyl]prop-2-enamide
CAS 444182-55-2C16H15F3N2O2
2-Cyano-3-[4-(difluoromethoxy)phenyl]-N-[(oxolan-2-yl)methyl]prop-2-enamide chemical structure, C16H16F2N2O3, CAS 326031-01-0
2-Cyano-3-[4-(difluoromethoxy)phenyl]-N-[(oxolan-2-yl)methyl]prop-2-enamide
CAS 326031-01-0C16H16F2N2O3
(Z)-2-Cyano-N-(oxolan-2-ylmethyl)-3-phenylprop-2-enamide chemical structure, C15H16N2O2, CAS 358279-60-4
(Z)-2-Cyano-N-(oxolan-2-ylmethyl)-3-phenylprop-2-enamide
CAS 358279-60-4C15H16N2O2
3-(5-Bromo-2-hydroxyphenyl)-2-cyano-N-[(oxolan-2-yl)methyl]prop-2-enamide chemical structure, C15H15BrN2O3, CAS 358280-56-5
3-(5-Bromo-2-hydroxyphenyl)-2-cyano-N-[(oxolan-2-yl)methyl]prop-2-enamide
CAS 358280-56-5C15H15BrN2O3
3-(3-Chloro-5-ethoxy-4-methoxyphenyl)-2-cyano-N-[(oxolan-2-yl)methyl]prop-2-enamide chemical structure, C18H21ClN2O4, CAS 941016-89-3
3-(3-Chloro-5-ethoxy-4-methoxyphenyl)-2-cyano-N-[(oxolan-2-yl)methyl]prop-2-enamide
CAS 941016-89-3C18H21ClN2O4
(E)-3-(3-Chloro-5-ethoxy-4-hydroxyphenyl)-2-cyano-N-(oxolan-2-ylmethyl)prop-2-enamide chemical structure, C17H19ClN2O4, CAS 444690-26-0
(E)-3-(3-Chloro-5-ethoxy-4-hydroxyphenyl)-2-cyano-N-(oxolan-2-ylmethyl)prop-2-enamide
CAS 444690-26-0C17H19ClN2O4
2-Cyano-3-[4-methoxy-2-(propan-2-yloxy)phenyl]-N-[(oxolan-2-yl)methyl]prop-2-enamide chemical structure, C19H24N2O4, CAS 1385619-83-9
2-Cyano-3-[4-methoxy-2-(propan-2-yloxy)phenyl]-N-[(oxolan-2-yl)methyl]prop-2-enamide
CAS 1385619-83-9C19H24N2O4