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Murcko scaffold

2-Piperazin-1-yl-1H-benzoimidazole scaffold

65 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
15
Chemicals
65
With full pages
6
Scaffold SMILES

c1ccc2[nH]c(N3CCNCC3)nc2c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Piperazin-1-yl-1H-benzoimidazole page
Murcko scaffold c1ccc2[nH]c(N3CCNCC3)nc2c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 65 chemicals

1-Methyl-2-(piperazin-1-yl)-1H-benzo[d]imidazole chemical structure, C12H16N4, CAS 137898-68-1
1-Methyl-2-(piperazin-1-yl)-1H-benzo[d]imidazole
CAS 137898-68-1C12H16N4
4-(1-Ethyl-1H-benzoimidazol-2-yl)-piperazine-1-carbothioic acid methylamide chemical structure, C15H21N5S, CAS 604741-64-2
4-(1-Ethyl-1H-benzoimidazol-2-yl)-piperazine-1-carbothioic acid methylamide
CAS 604741-64-2C15H21N5S
4-(1-Ethyl-1H-benzoimidazol-2-yl)-piperazine-1-carbothioic acid isobutyl-amide chemical structure, C18H27N5S, CAS 604741-66-4
4-(1-Ethyl-1H-benzoimidazol-2-yl)-piperazine-1-carbothioic acid isobutyl-amide
CAS 604741-66-4C18H27N5S
1-Ethyl-2-(4-(ethylsulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole chemical structure, C15H22N4O2S, CAS 604741-69-7
1-Ethyl-2-(4-(ethylsulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole
CAS 604741-69-7C15H22N4O2S
2-Piperazin-1-yl-1H-benzoimidazole chemical structure, C11H14N4, CAS 57260-68-1
2-Piperazin-1-yl-1H-benzoimidazole
CAS 57260-68-1C11H14N4
2-(4-Methyl-1-piperazinyl)-1H-benzimidazole chemical structure, C12H16N4, CAS 57897-93-5
2-(4-Methyl-1-piperazinyl)-1H-benzimidazole
CAS 57897-93-5C12H16N4
1-(2-Ethoxyethyl)-2-(4-methylpiperazin-1-yl)benzimidazole chemical structure, C16H24N4O, CAS 87233-65-6
1-(2-Ethoxyethyl)-2-(4-methylpiperazin-1-yl)benzimidazole
CAS 87233-65-6C16H24N4O
1H-Benzimidazol-6-amine, 5-chloro-1-(1-methylethyl)-2-(4-methyl-1-piperazinyl)- chemical structure, C15H22ClN5, CAS 148014-93-1
1H-Benzimidazol-6-amine, 5-chloro-1-(1-methylethyl)-2-(4-methyl-1-piperazinyl)-
CAS 148014-93-1C15H22ClN5
5-Chloro-2-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazole chemical structure, C12H15ClN4, CAS 380643-08-3
5-Chloro-2-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazole
CAS 380643-08-3C12H15ClN4
1H-Benzimidazole, 2-(4-methyl-1-piperazinyl)-1-(2-(2-propynyloxy)ethyl)-, (E)-2-butenedioate(2:3) chemical structure, C46H56N8O14, CAS 87233-60-1
1H-Benzimidazole, 2-(4-methyl-1-piperazinyl)-1-(2-(2-propynyloxy)ethyl)-, (E)-2-butenedioate(2:3)
CAS 87233-60-1C46H56N8O14
1H-Benzimidazole, 2-(4-methyl-1-piperazinyl)-1-(2-(2-propenyloxy)ethyl)-, (E)-2-butenedioate(2:3) chemical structure, C46H60N8O14, CAS 87233-64-5
1H-Benzimidazole, 2-(4-methyl-1-piperazinyl)-1-(2-(2-propenyloxy)ethyl)-, (E)-2-butenedioate(2:3)
CAS 87233-64-5C46H60N8O14
1H-Benzimidazole, 1-(2-ethoxyethyl)-2-(4-methyl-1-piperazinyl)-, (E)-2-butenedioate (2:3) chemical structure, C44H60N8O14, CAS 87233-66-7
1H-Benzimidazole, 1-(2-ethoxyethyl)-2-(4-methyl-1-piperazinyl)-, (E)-2-butenedioate (2:3)
CAS 87233-66-7C44H60N8O14
1H-Benzimidazole, 1-(2-ethoxyethyl)-2-(1-piperazinyl)-, (E)-2-butenedioate (2:3) chemical structure, C42H56N8O14, CAS 87233-70-3
1H-Benzimidazole, 1-(2-ethoxyethyl)-2-(1-piperazinyl)-, (E)-2-butenedioate (2:3)
CAS 87233-70-3C42H56N8O14
1H-Benzimidazole, 1-(2-ethoxyethyl)-2-(4-ethyl-1-piperazinyl)-, (E)-2-butenedioate (2:3) chemical structure, C46H64N8O14, CAS 87233-72-5
1H-Benzimidazole, 1-(2-ethoxyethyl)-2-(4-ethyl-1-piperazinyl)-, (E)-2-butenedioate (2:3)
CAS 87233-72-5C46H64N8O14
1H-Benzimidazole, 2-(4-methyl-1-piperazinyl)-1-(2-propoxyethyl)-, (E)-2-butenedioate (2:3) chemical structure, C46H64N8O14, CAS 87233-76-9
1H-Benzimidazole, 2-(4-methyl-1-piperazinyl)-1-(2-propoxyethyl)-, (E)-2-butenedioate (2:3)
CAS 87233-76-9C46H64N8O14
KB R6933 chemical structure, C23H30ClN5O8, CAS 148565-09-7
KB R6933
CAS 148565-09-7C23H30ClN5O8
1H-Benzimidazole, 1-ethyl-2-(1-piperazinyl)- chemical structure, C13H18N4, CAS 145909-56-4
1H-Benzimidazole, 1-ethyl-2-(1-piperazinyl)-
CAS 145909-56-4C13H18N4
5-Methyl-2-(piperazin-1-yl)-1H-1,3-benzodiazole chemical structure, C12H16N4, CAS 946668-09-3
5-Methyl-2-(piperazin-1-yl)-1H-1,3-benzodiazole
CAS 946668-09-3C12H16N4
tert-Butyl 4-(1H-benzimidazol-2-yl)piperazine-1-carboxylate chemical structure, C16H22N4O2, CAS 295341-56-9
tert-Butyl 4-(1H-benzimidazol-2-yl)piperazine-1-carboxylate
CAS 295341-56-9C16H22N4O2
2-(1-Piperazinyl)-1H-benzimidazole-7-carboxamide chemical structure, C12H15N5O, CAS 272769-54-7
2-(1-Piperazinyl)-1H-benzimidazole-7-carboxamide
CAS 272769-54-7C12H15N5O
6-Nitro-2-(1-piperazinyl)-1H-benzimidazole chemical structure, C11H13N5O2, CAS 401567-05-3
6-Nitro-2-(1-piperazinyl)-1H-benzimidazole
CAS 401567-05-3C11H13N5O2
2-(4-(Ethylsulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole chemical structure, C13H18N4O2S, CAS 1208959-59-4
2-(4-(Ethylsulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole
CAS 1208959-59-4C13H18N4O2S
2-(4-(Propylsulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole chemical structure, C14H20N4O2S, CAS 1210171-72-4
2-(4-(Propylsulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole
CAS 1210171-72-4C14H20N4O2S
2-(4-(Butylsulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole chemical structure, C15H22N4O2S, CAS 1210491-46-5
2-(4-(Butylsulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole
CAS 1210491-46-5C15H22N4O2S