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Murcko scaffold

2-(Phenylacetyl)-1,2,3,4-tetrahydroisoquinoline scaffold

14 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
14
With full pages
5
Scaffold SMILES

O=C(Cc1ccccc1)N1CCc2ccccc2C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(Phenylacetyl)-1,2,3,4-tetrahydroisoquinoline page
Murcko scaffold O=C(Cc1ccccc1)N1CCc2ccccc2C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

RefChem:381376 chemical structure, C17H16BrNO, CAS 6602-96-6
RefChem:381376
CAS 6602-96-6C17H16BrNO
2-(Phenylacetyl)-1,2,3,4-tetrahydroisoquinoline chemical structure, C17H17NO, CAS 90862-37-6
2-(Phenylacetyl)-1,2,3,4-tetrahydroisoquinoline
CAS 90862-37-6C17H17NO
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-(2-methoxyphenyl)ethanone chemical structure, C18H19NO2, CAS 328287-14-5
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-(2-methoxyphenyl)ethanone
CAS 328287-14-5C18H19NO2
2-[(4-Chlorophenyl)acetyl]-1,2,3,4-tetrahydroisoquinoline chemical structure, C17H16ClNO, CAS 329043-32-5
2-[(4-Chlorophenyl)acetyl]-1,2,3,4-tetrahydroisoquinoline
CAS 329043-32-5C17H16ClNO
2-(2-Chloro-6-fluorophenyl)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone chemical structure, C17H15ClFNO, CAS 793720-89-5
2-(2-Chloro-6-fluorophenyl)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone
CAS 793720-89-5C17H15ClFNO
6,7-Dimethoxy-2-[(4-nitrophenyl)acetyl]-1,2,3,4-tetrahydroisoquinoline chemical structure, C19H20N2O5, CAS 82924-82-1
6,7-Dimethoxy-2-[(4-nitrophenyl)acetyl]-1,2,3,4-tetrahydroisoquinoline
CAS 82924-82-1C19H20N2O5
1-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(4-(isopropylsulfonyl)phenyl)ethanone chemical structure, C20H23NO3S, CAS 955596-79-9
1-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(4-(isopropylsulfonyl)phenyl)ethanone
CAS 955596-79-9C20H23NO3S
1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-2-(2,4,5-trifluorophenyl)ethanone chemical structure, C19H18F3NO3, CAS 1574403-90-9
1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-2-(2,4,5-trifluorophenyl)ethanone
CAS 1574403-90-9C19H18F3NO3
Mevidalen chemical structure, C24H29Cl2NO3, CAS 1638667-79-4
Mevidalen
CAS 1638667-79-4C24H29Cl2NO3
2-(3-Chlorophenyl)-1-(3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one chemical structure, C17H16ClNO, CAS 2199881-01-9
2-(3-Chlorophenyl)-1-(3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one
CAS 2199881-01-9C17H16ClNO
2-(2,6-Dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(2-hydroxypropan-2-yl)-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl]ethan-1-one chemical structure, C22H25Cl2NO3, CAS 1638667-81-8
2-(2,6-Dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(2-hydroxypropan-2-yl)-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl]ethan-1-one
CAS 1638667-81-8C22H25Cl2NO3
2-(2,6-Dichlorophenyl)-1-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one chemical structure, C18H17Cl2NO, CAS 1904660-14-5
2-(2,6-Dichlorophenyl)-1-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one
CAS 1904660-14-5C18H17Cl2NO
Mevidalen hydroxybenzoate chemical structure, C31H35Cl2NO6, CAS 1638669-32-5
Mevidalen hydroxybenzoate
CAS 1638669-32-5C31H35Cl2NO6
Influenza virus-IN-2 chemical structure, C17H17NO5, CAS 2411584-06-8
Influenza virus-IN-2
CAS 2411584-06-8C17H17NO5