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Murcko scaffold

Ring system with 2 rings and 15 atoms

143 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
143
With full pages
31
Scaffold SMILES

C(=Nc1ncccn1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C(=Nc1ncccn1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 143 chemicals

Guanidine, 1-(4,6-dimethyl-2-pyrimidinyl)-3-(p-nitrophenyl)- chemical structure, C13H14N6O2, CAS 4323-53-9
Guanidine, 1-(4,6-dimethyl-2-pyrimidinyl)-3-(p-nitrophenyl)-
CAS 4323-53-9C13H14N6O2
1-(4,6-Dimethylpyrimidin-2-yl)-3-phenylguanidine chemical structure, C13H15N5, CAS 16018-49-8
1-(4,6-Dimethylpyrimidin-2-yl)-3-phenylguanidine
CAS 16018-49-8C13H15N5
Guanidine, 1-(p-bromophenyl)-3-(4,6-dimethyl-2-pyrimidinyl)- chemical structure, C13H14BrN5, CAS 16018-66-9
Guanidine, 1-(p-bromophenyl)-3-(4,6-dimethyl-2-pyrimidinyl)-
CAS 16018-66-9C13H14BrN5
1-(3,4-Dichlorophenyl)-2-[4-[1-(dimethylamino)propan-2-ylamino]-6-methylpyrimidin-2-yl]guanidine chemical structure, C17H23Cl2N7, CAS 51386-95-9
1-(3,4-Dichlorophenyl)-2-[4-[1-(dimethylamino)propan-2-ylamino]-6-methylpyrimidin-2-yl]guanidine
CAS 51386-95-9C17H23Cl2N7
1-(4,6-Dimethylpyrimidin-2-yl)-3-(4-hydroxyphenyl)guanidine chemical structure, C13H15N5O, CAS 332074-04-1
1-(4,6-Dimethylpyrimidin-2-yl)-3-(4-hydroxyphenyl)guanidine
CAS 332074-04-1C13H15N5O
1-(4,6-Dimethylpyrimidin-2-yl)-3-(2-ethoxyphenyl)guanidine chemical structure, C15H19N5O
1-(4,6-Dimethylpyrimidin-2-yl)-3-(2-ethoxyphenyl)guanidine
C15H19N5O
N-(4,6-Dimethylpyrimidin-2-yl)-N'-(2-propoxyphenyl)guanidine chemical structure, C16H21N5O
N-(4,6-Dimethylpyrimidin-2-yl)-N'-(2-propoxyphenyl)guanidine
C16H21N5O
N-(4-Chloro-6-propylpyrimidin-2-yl)-N'-(2,4-difluorophenyl)guanidine chemical structure, C14H14ClF2N5, CAS 680214-82-8
N-(4-Chloro-6-propylpyrimidin-2-yl)-N'-(2,4-difluorophenyl)guanidine
CAS 680214-82-8C14H14ClF2N5
1-(4,6-Dimethylpyrimidin-2-yl)-3-(4-methoxyphenyl)guanidine chemical structure, C14H17N5O
1-(4,6-Dimethylpyrimidin-2-yl)-3-(4-methoxyphenyl)guanidine
C14H17N5O
1-(4,6-Dimethylpyrimidin-2-yl)-3-(p-tolyl)guanidine chemical structure, C14H17N5
1-(4,6-Dimethylpyrimidin-2-yl)-3-(p-tolyl)guanidine
C14H17N5
1-(4,6-Dimethylpyrimidin-2-yl)-3-(2-methoxyphenyl)guanidine chemical structure, C14H17N5O
1-(4,6-Dimethylpyrimidin-2-yl)-3-(2-methoxyphenyl)guanidine
C14H17N5O
N-(4,6-Dimethylpyrimidin-2-yl)-N'-(3-methylphenyl)guanidine chemical structure, C14H17N5
N-(4,6-Dimethylpyrimidin-2-yl)-N'-(3-methylphenyl)guanidine
C14H17N5
1-(4,6-Dimethylpyrimidin-2-yl)-3-(3-(trifluoromethyl)phenyl)guanidine chemical structure, C14H14F3N5
1-(4,6-Dimethylpyrimidin-2-yl)-3-(3-(trifluoromethyl)phenyl)guanidine
C14H14F3N5
1-(4,6-Dimethylpyrimidin-2-yl)-3-(3-methoxyphenyl)guanidine chemical structure, C14H17N5O, CAS 351190-34-6
1-(4,6-Dimethylpyrimidin-2-yl)-3-(3-methoxyphenyl)guanidine
CAS 351190-34-6C14H17N5O
N-(3-Chlorophenyl)-N'-(4,6-dimethylpyrimidin-2-yl)guanidine chemical structure, C13H14ClN5, CAS 332073-82-2
N-(3-Chlorophenyl)-N'-(4,6-dimethylpyrimidin-2-yl)guanidine
CAS 332073-82-2C13H14ClN5
1-(3,4-Dimethoxyphenyl)-3-(4,6-dimethylpyrimidin-2-yl)guanidine chemical structure, C15H19N5O2, CAS 332073-81-1
1-(3,4-Dimethoxyphenyl)-3-(4,6-dimethylpyrimidin-2-yl)guanidine
CAS 332073-81-1C15H19N5O2
1-(3,4-Dimethylphenyl)-3-(4,6-dimethylpyrimidin-2-yl)guanidine chemical structure, C15H19N5, CAS 332073-80-0
1-(3,4-Dimethylphenyl)-3-(4,6-dimethylpyrimidin-2-yl)guanidine
CAS 332073-80-0C15H19N5
1-(2-Chloro-5-(trifluoromethyl)phenyl)-3-(4,6-dimethylpyrimidin-2-yl)guanidine chemical structure, C14H13ClF3N5
1-(2-Chloro-5-(trifluoromethyl)phenyl)-3-(4,6-dimethylpyrimidin-2-yl)guanidine
C14H13ClF3N5
1-(3,5-Dichlorophenyl)-3-(4,6-dimethylpyrimidin-2-yl)guanidine chemical structure, C13H13Cl2N5
1-(3,5-Dichlorophenyl)-3-(4,6-dimethylpyrimidin-2-yl)guanidine
C13H13Cl2N5
N-((4-(3-(4,6-Dimethylpyrimidin-2-yl)guanidino)phenyl)sulfonyl)acetamide chemical structure, C15H18N6O3S
N-((4-(3-(4,6-Dimethylpyrimidin-2-yl)guanidino)phenyl)sulfonyl)acetamide
C15H18N6O3S
N-(4,6-Dimethylpyrimidin-2-yl)-N'-(2-hydroxyphenyl)guanidine chemical structure, C13H15N5O
N-(4,6-Dimethylpyrimidin-2-yl)-N'-(2-hydroxyphenyl)guanidine
C13H15N5O
4-[[N'-(4,6-Dimethylpyrimidin-2-yl)carbamimidoyl]amino]benzoic acid chemical structure, C14H15N5O2, CAS 354994-01-7
4-[[N'-(4,6-Dimethylpyrimidin-2-yl)carbamimidoyl]amino]benzoic acid
CAS 354994-01-7C14H15N5O2
2-(4,6-Dimethylpyrimidin-2-yl)-1-[2-(trifluoromethyl)phenyl]guanidine chemical structure, C14H14F3N5, CAS 303094-67-9
2-(4,6-Dimethylpyrimidin-2-yl)-1-[2-(trifluoromethyl)phenyl]guanidine
CAS 303094-67-9C14H14F3N5
1-(4,6-Dimethylpyrimidin-2-yl)-3-(2-ethylphenyl)guanidine chemical structure, C15H19N5, CAS 332938-09-7
1-(4,6-Dimethylpyrimidin-2-yl)-3-(2-ethylphenyl)guanidine
CAS 332938-09-7C15H19N5