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Murcko scaffold

Ring system with 3 rings and 18 atoms

41 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
41
With full pages
13
Scaffold SMILES

c1ccc(CSc2nnc(-c3cccs3)[nH]2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(CSc2nnc(-c3cccs3)[nH]2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 41 of 41 chemicals

3-[(2,6-Dichlorophenyl)methylthio]-4-methyl-5-thiophen-2-yl-1,2,4-triazole chemical structure, C14H11Cl2N3S2, CAS 676522-70-6
3-[(2,6-Dichlorophenyl)methylthio]-4-methyl-5-thiophen-2-yl-1,2,4-triazole
CAS 676522-70-6C14H11Cl2N3S2
3-[(2-Chloro-6-fluorobenzyl)sulfanyl]-4-methyl-5-(thiophen-2-yl)-4H-1,2,4-triazole chemical structure, C14H11ClFN3S2, CAS 577768-52-6
3-[(2-Chloro-6-fluorobenzyl)sulfanyl]-4-methyl-5-(thiophen-2-yl)-4H-1,2,4-triazole
CAS 577768-52-6C14H11ClFN3S2
3-[(4-Bromophenyl)methylthio]-4-methyl-5-(2-thienyl)-1,2,4-triazole chemical structure, C14H12BrN3S2, CAS 676440-55-4
3-[(4-Bromophenyl)methylthio]-4-methyl-5-(2-thienyl)-1,2,4-triazole
CAS 676440-55-4C14H12BrN3S2
3-{[(4-Fluorophenyl)methyl]sulfanyl}-4-methyl-5-(thiophen-2-yl)-4H-1,2,4-triazole chemical structure, C14H12FN3S2, CAS 329699-48-1
3-{[(4-Fluorophenyl)methyl]sulfanyl}-4-methyl-5-(thiophen-2-yl)-4H-1,2,4-triazole
CAS 329699-48-1C14H12FN3S2
3-(Benzylsulfanyl)-4-methyl-5-(thiophen-2-yl)-4H-1,2,4-triazole chemical structure, C14H13N3S2, CAS 586995-86-0
3-(Benzylsulfanyl)-4-methyl-5-(thiophen-2-yl)-4H-1,2,4-triazole
CAS 586995-86-0C14H13N3S2
4-Methyl-3-{[(2-methylphenyl)methyl]sulfanyl}-5-(thiophen-2-yl)-4H-1,2,4-triazole chemical structure, C15H15N3S2, CAS 294848-72-9
4-Methyl-3-{[(2-methylphenyl)methyl]sulfanyl}-5-(thiophen-2-yl)-4H-1,2,4-triazole
CAS 294848-72-9C15H15N3S2
3-[(4-tert-Butylphenyl)methylsulfanyl]-4-methyl-5-thiophen-2-yl-1,2,4-triazole chemical structure, C18H21N3S2, CAS 294848-69-4
3-[(4-tert-Butylphenyl)methylsulfanyl]-4-methyl-5-thiophen-2-yl-1,2,4-triazole
CAS 294848-69-4C18H21N3S2
3-[(3-Fluorobenzyl)sulfanyl]-4-methyl-5-(thiophen-2-yl)-4H-1,2,4-triazole chemical structure, C14H12FN3S2, CAS 585561-66-6
3-[(3-Fluorobenzyl)sulfanyl]-4-methyl-5-(thiophen-2-yl)-4H-1,2,4-triazole
CAS 585561-66-6C14H12FN3S2
3-{[(3-Methoxyphenyl)methyl]sulfanyl}-4-methyl-5-(thiophen-2-yl)-4H-1,2,4-triazole chemical structure, C15H15N3OS2, CAS 678546-61-7
3-{[(3-Methoxyphenyl)methyl]sulfanyl}-4-methyl-5-(thiophen-2-yl)-4H-1,2,4-triazole
CAS 678546-61-7C15H15N3OS2
4-Allyl-3-((3-fluorobenzyl)thio)-5-(2-thienyl)-4H-1,2,4-triazole chemical structure, C16H14FN3S2, CAS 618879-81-5
4-Allyl-3-((3-fluorobenzyl)thio)-5-(2-thienyl)-4H-1,2,4-triazole
CAS 618879-81-5C16H14FN3S2
4-Methyl-3-[(3-methylbenzyl)sulfanyl]-5-(thiophen-2-yl)-4H-1,2,4-triazole chemical structure, C15H15N3S2, CAS 677730-11-9
4-Methyl-3-[(3-methylbenzyl)sulfanyl]-5-(thiophen-2-yl)-4H-1,2,4-triazole
CAS 677730-11-9C15H15N3S2
3-[(2,6-Difluorobenzyl)sulfanyl]-4-methyl-5-(thiophen-2-yl)-4H-1,2,4-triazole chemical structure, C14H11F2N3S2, CAS 676336-20-2
3-[(2,6-Difluorobenzyl)sulfanyl]-4-methyl-5-(thiophen-2-yl)-4H-1,2,4-triazole
CAS 676336-20-2C14H11F2N3S2
3-((3-Chlorobenzyl)thio)-4-ethyl-5-(2-thienyl)-4H-1,2,4-triazole chemical structure, C15H14ClN3S2, CAS 577765-41-4
3-((3-Chlorobenzyl)thio)-4-ethyl-5-(2-thienyl)-4H-1,2,4-triazole
CAS 577765-41-4C15H14ClN3S2
4-({[4-Methyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}methyl)benzonitrile chemical structure, C15H12N4S2, CAS 573971-82-1
4-({[4-Methyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}methyl)benzonitrile
CAS 573971-82-1C15H12N4S2
3-Benzylsulfanyl-4-ethyl-5-thiophen-2-yl-1,2,4-triazole chemical structure, C15H15N3S2, CAS 578749-47-0
3-Benzylsulfanyl-4-ethyl-5-thiophen-2-yl-1,2,4-triazole
CAS 578749-47-0C15H15N3S2
4-Allyl-3-((3-chlorobenzyl)thio)-5-(2-thienyl)-4H-1,2,4-triazole chemical structure, C16H14ClN3S2, CAS 577964-09-1
4-Allyl-3-((3-chlorobenzyl)thio)-5-(2-thienyl)-4H-1,2,4-triazole
CAS 577964-09-1C16H14ClN3S2
3-[(4-Nitrophenyl)methylthio]-4-prop-2-enyl-5-(2-thienyl)-1,2,4-triazole chemical structure, C16H14N4O2S2, CAS 488746-46-9
3-[(4-Nitrophenyl)methylthio]-4-prop-2-enyl-5-(2-thienyl)-1,2,4-triazole
CAS 488746-46-9C16H14N4O2S2
3-[(2-Chlorobenzyl)sulfanyl]-5-(2-thienyl)-4H-1,2,4-triazol-4-ylamine chemical structure, C13H11ClN4S2, CAS 477872-63-2
3-[(2-Chlorobenzyl)sulfanyl]-5-(2-thienyl)-4H-1,2,4-triazol-4-ylamine
CAS 477872-63-2C13H11ClN4S2
3-[(3-Chlorobenzyl)sulfanyl]-5-(2-thienyl)-4H-1,2,4-triazol-4-ylamine chemical structure, C13H11ClN4S2, CAS 477872-64-3
3-[(3-Chlorobenzyl)sulfanyl]-5-(2-thienyl)-4H-1,2,4-triazol-4-ylamine
CAS 477872-64-3C13H11ClN4S2
3-[(2-Methylbenzyl)sulfanyl]-5-(2-thienyl)-4H-1,2,4-triazol-4-ylamine chemical structure, C14H14N4S2, CAS 477872-65-4
3-[(2-Methylbenzyl)sulfanyl]-5-(2-thienyl)-4H-1,2,4-triazol-4-ylamine
CAS 477872-65-4C14H14N4S2
3-[(4-Chlorobenzyl)sulfanyl]-5-(2-thienyl)-4H-1,2,4-triazol-4-ylamine chemical structure, C13H11ClN4S2, CAS 477872-66-5
3-[(4-Chlorobenzyl)sulfanyl]-5-(2-thienyl)-4H-1,2,4-triazol-4-ylamine
CAS 477872-66-5C13H11ClN4S2
Methyl 4-({[4-amino-5-(2-thienyl)-4H-1,2,4-triazol-3-yl]sulfanyl}methyl)benzenecarboxylate chemical structure, C15H14N4O2S2, CAS 477872-67-6
Methyl 4-({[4-amino-5-(2-thienyl)-4H-1,2,4-triazol-3-yl]sulfanyl}methyl)benzenecarboxylate
CAS 477872-67-6C15H14N4O2S2
3-[(3-Fluorobenzyl)sulfanyl]-5-(2-thienyl)-4H-1,2,4-triazol-4-ylamine chemical structure, C13H11FN4S2, CAS 477872-68-7
3-[(3-Fluorobenzyl)sulfanyl]-5-(2-thienyl)-4H-1,2,4-triazol-4-ylamine
CAS 477872-68-7C13H11FN4S2
3-{[(3-Bromophenyl)methyl]sulfanyl}-4-methyl-5-(thiophen-2-yl)-4H-1,2,4-triazole chemical structure, C14H12BrN3S2, CAS 329699-46-9
3-{[(3-Bromophenyl)methyl]sulfanyl}-4-methyl-5-(thiophen-2-yl)-4H-1,2,4-triazole
CAS 329699-46-9C14H12BrN3S2