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Murcko scaffold

Ring system with 3 rings and 17 atoms

227 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
227
With full pages
23
Scaffold SMILES

O=C(Nc1cc2c(s1)CCC2)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1cc2c(s1)CCC2)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 227 chemicals

Ethyl 2-(benzoylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C17H17NO3S, CAS 189067-61-6
Ethyl 2-(benzoylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 189067-61-6C17H17NO3S
Methyl 2-[(2-methylbenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C17H17NO3S, CAS 328023-50-3
Methyl 2-[(2-methylbenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 328023-50-3C17H17NO3S
2-[(2-Fluorobenzoyl)amino]-N-methyl-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C16H15FN2O2S, CAS 397852-82-3
2-[(2-Fluorobenzoyl)amino]-N-methyl-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 397852-82-3C16H15FN2O2S
3-Bromo-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)benzamide chemical structure, C15H11BrN2OS, CAS 321945-21-5
3-Bromo-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)benzamide
CAS 321945-21-5C15H11BrN2OS
Ethyl 2-[(2-fluorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C17H16FNO3S, CAS 307536-69-2
Ethyl 2-[(2-fluorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 307536-69-2C17H16FNO3S
N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-phthalamic acid chemical structure, C16H12N2O3S, CAS 312915-08-5
N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-phthalamic acid
CAS 312915-08-5C16H12N2O3S
Methyl 2-[(4-fluorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C16H14FNO3S, CAS 313703-23-0
Methyl 2-[(4-fluorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 313703-23-0C16H14FNO3S
Ethyl 2-(4-methylbenzamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C18H19NO3S, CAS 300826-05-5
Ethyl 2-(4-methylbenzamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 300826-05-5C18H19NO3S
Ethyl 2-[(4-fluorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C17H16FNO3S, CAS 300828-93-7
Ethyl 2-[(4-fluorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 300828-93-7C17H16FNO3S
Methyl 2-[(4-nitrobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C16H14N2O5S, CAS 302803-06-1
Methyl 2-[(4-nitrobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 302803-06-1C16H14N2O5S
N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-2,6-dimethoxybenzamide chemical structure, C17H16N2O3S, CAS 447449-96-9
N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-2,6-dimethoxybenzamide
CAS 447449-96-9C17H16N2O3S
2-Chloro-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)benzamide chemical structure, C15H11ClN2OS, CAS 312917-49-0
2-Chloro-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)benzamide
CAS 312917-49-0C15H11ClN2OS
Ethyl 2-(4-methoxybenzamido)-4H,5H,6H-cyclopenta[B]thiophene-3-carboxylate chemical structure, C18H19NO4S, CAS 300826-06-6
Ethyl 2-(4-methoxybenzamido)-4H,5H,6H-cyclopenta[B]thiophene-3-carboxylate
CAS 300826-06-6C18H19NO4S
Ethyl 2-[(2-chlorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C17H16ClNO3S, CAS 300828-82-4
Ethyl 2-[(2-chlorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 300828-82-4C17H16ClNO3S
2-((3-(Methoxycarbonyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)carbamoyl)benzoic acid chemical structure, C17H15NO5S, CAS 328024-25-5
2-((3-(Methoxycarbonyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)carbamoyl)benzoic acid
CAS 328024-25-5C17H15NO5S
2-Benzoylamino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid amide chemical structure, C15H14N2O2S, CAS 5534-31-6
2-Benzoylamino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid amide
CAS 5534-31-6C15H14N2O2S
N,N-Dimethyl-2-[(3-methylbenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C18H20N2O2S, CAS 397854-86-3
N,N-Dimethyl-2-[(3-methylbenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 397854-86-3C18H20N2O2S
Methyl 2-[(3-chlorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C16H14ClNO3S, CAS 302803-03-8
Methyl 2-[(3-chlorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 302803-03-8C16H14ClNO3S
Methyl 2-[(2-methoxybenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C17H17NO4S, CAS 302803-08-3
Methyl 2-[(2-methoxybenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 302803-08-3C17H17NO4S
Methyl 2-[(2-fluorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C16H14FNO3S, CAS 419558-86-4
Methyl 2-[(2-fluorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 419558-86-4C16H14FNO3S
2-Benzamido-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid chemical structure, C15H13NO3S, CAS 307341-55-5
2-Benzamido-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid
CAS 307341-55-5C15H13NO3S
2-[(2-Chlorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid chemical structure, C15H12ClNO3S, CAS 326611-23-8
2-[(2-Chlorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid
CAS 326611-23-8C15H12ClNO3S
4-Chloro-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)benzamide chemical structure, C15H11ClN2OS, CAS 300712-82-7
4-Chloro-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)benzamide
CAS 300712-82-7C15H11ClN2OS
Ethyl 2-[(3-methylbenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C18H19NO3S, CAS 312917-74-1
Ethyl 2-[(3-methylbenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 312917-74-1C18H19NO3S