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Murcko scaffold

8-Phenyl-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one scaffold

50 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
50
With full pages
10
Scaffold SMILES

O=C1CC(c2ccccc2)c2cc3c(cc2N1)OCO3

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 8-Phenyl-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one page
Murcko scaffold O=C1CC(c2ccccc2)c2cc3c(cc2N1)OCO3

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 50 chemicals

8-(2-Ethoxyphenyl)-7,8-dihydro-(1,3)dioxolo(4,5-g)quinolin-6(5H)-one chemical structure, C18H17NO4, CAS 599151-35-6
8-(2-Ethoxyphenyl)-7,8-dihydro-(1,3)dioxolo(4,5-g)quinolin-6(5H)-one
CAS 599151-35-6C18H17NO4
8-(2-Fluorophenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one chemical structure, C16H12FNO3, CAS 443326-34-9
8-(2-Fluorophenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
CAS 443326-34-9C16H12FNO3
8-(4-Methoxyphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one chemical structure, C17H15NO4, CAS 599151-30-1
8-(4-Methoxyphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
CAS 599151-30-1C17H15NO4
8-(3-Ethoxyphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one chemical structure, C18H17NO4, CAS 599151-20-9
8-(3-Ethoxyphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
CAS 599151-20-9C18H17NO4
8-(3-Chlorophenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one chemical structure, C16H12ClNO3, CAS 599150-93-3
8-(3-Chlorophenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
CAS 599150-93-3C16H12ClNO3
8-[2-(Trifluoromethyl)phenyl]-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one chemical structure, C17H12F3NO3, CAS 599151-34-5
8-[2-(Trifluoromethyl)phenyl]-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
CAS 599151-34-5C17H12F3NO3
8-(2-Bromophenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one chemical structure, C16H12BrNO3, CAS 599151-22-1
8-(2-Bromophenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
CAS 599151-22-1C16H12BrNO3
8-(2,3-Dimethoxyphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one chemical structure, C18H17NO5, CAS 599151-17-4
8-(2,3-Dimethoxyphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
CAS 599151-17-4C18H17NO5
8-[3-(Trifluoromethyl)phenyl]-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one chemical structure, C17H12F3NO3, CAS 713106-43-5
8-[3-(Trifluoromethyl)phenyl]-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one
CAS 713106-43-5C17H12F3NO3
8-(5-Bromo-2-fluorophenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one chemical structure, C16H11BrFNO3, CAS 713106-45-7
8-(5-Bromo-2-fluorophenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
CAS 713106-45-7C16H11BrFNO3
8-(4-Methylsulfanylphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one chemical structure, C17H15NO3S, CAS 714281-09-1
8-(4-Methylsulfanylphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
CAS 714281-09-1C17H15NO3S
8-(3-Bromophenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one chemical structure, C16H12BrNO3, CAS 714281-10-4
8-(3-Bromophenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one
CAS 714281-10-4C16H12BrNO3
8-(2-Chloro-6-fluorophenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one chemical structure, C16H11ClFNO3, CAS 714281-12-6
8-(2-Chloro-6-fluorophenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one
CAS 714281-12-6C16H11ClFNO3
8-(3-Chloro-5-ethoxy-4-hydroxyphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one chemical structure, C18H16ClNO5, CAS 717874-30-1
8-(3-Chloro-5-ethoxy-4-hydroxyphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
CAS 717874-30-1C18H16ClNO5
8-(4-Propan-2-ylphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one chemical structure, C19H19NO3, CAS 717874-82-3
8-(4-Propan-2-ylphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
CAS 717874-82-3C19H19NO3
8-(3-Bromo-4,5-dimethoxyphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one chemical structure, C18H16BrNO5, CAS 717878-19-8
8-(3-Bromo-4,5-dimethoxyphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
CAS 717878-19-8C18H16BrNO5
Methyl 4-(6-oxo-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]quinolin-8-yl)benzoate chemical structure, C18H15NO5, CAS 717878-70-1
Methyl 4-(6-oxo-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]quinolin-8-yl)benzoate
CAS 717878-70-1C18H15NO5
8-Phenyl-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one chemical structure, C16H13NO3, CAS 717831-55-5
8-Phenyl-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one
CAS 717831-55-5C16H13NO3
8-(5-Chloro-2-methoxyphenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one chemical structure, C17H14ClNO4, CAS 717833-15-3
8-(5-Chloro-2-methoxyphenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one
CAS 717833-15-3C17H14ClNO4
8-(3-Methoxy-2-propoxyphenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one chemical structure, C20H21NO5, CAS 835890-69-2
8-(3-Methoxy-2-propoxyphenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one
CAS 835890-69-2C20H21NO5
8-(5-Chloro-2-ethoxyphenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one chemical structure, C18H16ClNO4, CAS 835891-02-6
8-(5-Chloro-2-ethoxyphenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one
CAS 835891-02-6C18H16ClNO4
8-(3-Bromo-4-fluorophenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one chemical structure, C16H11BrFNO3, CAS 838849-89-1
8-(3-Bromo-4-fluorophenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
CAS 838849-89-1C16H11BrFNO3
8-(4-Hydroxy-3,5-dimethoxyphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one chemical structure, C18H17NO6, CAS 847465-88-7
8-(4-Hydroxy-3,5-dimethoxyphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
CAS 847465-88-7C18H17NO6
8-(3,4-Difluorophenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one chemical structure, C16H11F2NO3, CAS 847466-37-9
8-(3,4-Difluorophenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
CAS 847466-37-9C16H11F2NO3