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Murcko scaffold

Ring system with 3 rings and 19 atoms

14 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
14
With full pages
4
Scaffold SMILES

O=C(Nc1cc(-c2ccccc2)cs1)C1CCCO1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1cc(-c2ccccc2)cs1)C1CCCO1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

Ethyl 2-(oxolan-2-ylcarbonylamino)-4-phenylthiophene-3-carboxylate chemical structure, C18H19NO4S, CAS 379243-17-1
Ethyl 2-(oxolan-2-ylcarbonylamino)-4-phenylthiophene-3-carboxylate
CAS 379243-17-1C18H19NO4S
Ethyl 2-(oxolane-2-carbonylamino)-4-(3,4,5-trimethylphenyl)thiophene-3-carboxylate chemical structure, C21H25NO4S, CAS 379243-76-2
Ethyl 2-(oxolane-2-carbonylamino)-4-(3,4,5-trimethylphenyl)thiophene-3-carboxylate
CAS 379243-76-2C21H25NO4S
N-(3-Carbamoyl-5-methyl-4-phenylthiophen-2-yl)oxolane-2-carboxamide chemical structure, C17H18N2O3S, CAS 495386-32-8
N-(3-Carbamoyl-5-methyl-4-phenylthiophen-2-yl)oxolane-2-carboxamide
CAS 495386-32-8C17H18N2O3S
Propan-2-yl 5-methyl-2-(oxolane-2-carbonylamino)-4-phenylthiophene-3-carboxylate chemical structure, C20H23NO4S, CAS 495395-16-9
Propan-2-yl 5-methyl-2-(oxolane-2-carbonylamino)-4-phenylthiophene-3-carboxylate
CAS 495395-16-9C20H23NO4S
Isopropyl 4-(4-chlorophenyl)-5-methyl-2-[(tetrahydro-2-furanylcarbonyl)amino]-3-thiophenecarboxylate chemical structure, C20H22ClNO4S, CAS 495382-82-6
Isopropyl 4-(4-chlorophenyl)-5-methyl-2-[(tetrahydro-2-furanylcarbonyl)amino]-3-thiophenecarboxylate
CAS 495382-82-6C20H22ClNO4S
Isopropyl 4-(4-ethylphenyl)-2-[(tetrahydro-2-furanylcarbonyl)amino]-3-thiophenecarboxylate chemical structure, C21H25NO4S, CAS 495386-12-4
Isopropyl 4-(4-ethylphenyl)-2-[(tetrahydro-2-furanylcarbonyl)amino]-3-thiophenecarboxylate
CAS 495386-12-4C21H25NO4S
Propyl 5-methyl-2-(oxolane-2-carbonylamino)-4-(4-propan-2-ylphenyl)thiophene-3-carboxylate chemical structure, C23H29NO4S, CAS 444998-33-8
Propyl 5-methyl-2-(oxolane-2-carbonylamino)-4-(4-propan-2-ylphenyl)thiophene-3-carboxylate
CAS 444998-33-8C23H29NO4S
Isopropyl 4-(4-isopropylphenyl)-2-[(tetrahydro-2-furanylcarbonyl)amino]-3-thiophenecarboxylate chemical structure, C22H27NO4S, CAS 495383-44-3
Isopropyl 4-(4-isopropylphenyl)-2-[(tetrahydro-2-furanylcarbonyl)amino]-3-thiophenecarboxylate
CAS 495383-44-3C22H27NO4S
Propyl 4-(4-ethylphenyl)-5-methyl-2-(oxolane-2-carbonylamino)thiophene-3-carboxylate chemical structure, C22H27NO4S, CAS 445007-99-8
Propyl 4-(4-ethylphenyl)-5-methyl-2-(oxolane-2-carbonylamino)thiophene-3-carboxylate
CAS 445007-99-8C22H27NO4S
Propan-2-yl 4-(4-methoxyphenyl)-5-methyl-2-(oxolane-2-carbonylamino)thiophene-3-carboxylate chemical structure, C21H25NO5S, CAS 495382-59-7
Propan-2-yl 4-(4-methoxyphenyl)-5-methyl-2-(oxolane-2-carbonylamino)thiophene-3-carboxylate
CAS 495382-59-7C21H25NO5S
Ethyl 4-(2,4-dichlorophenyl)-2-(oxolane-2-carbonylamino)thiophene-3-carboxylate chemical structure, C18H17Cl2NO4S, CAS 495382-92-8
Ethyl 4-(2,4-dichlorophenyl)-2-(oxolane-2-carbonylamino)thiophene-3-carboxylate
CAS 495382-92-8C18H17Cl2NO4S
Ethyl 5-methyl-4-[4-(2-methylpropyl)phenyl]-2-(oxolane-2-carbonylamino)thiophene-3-carboxylate chemical structure, C23H29NO4S, CAS 445002-30-2
Ethyl 5-methyl-4-[4-(2-methylpropyl)phenyl]-2-(oxolane-2-carbonylamino)thiophene-3-carboxylate
CAS 445002-30-2C23H29NO4S
Methyl 4-(4-ethylphenyl)-5-methyl-2-(oxolane-2-carbonylamino)thiophene-3-carboxylate chemical structure, C20H23NO4S, CAS 495386-42-0
Methyl 4-(4-ethylphenyl)-5-methyl-2-(oxolane-2-carbonylamino)thiophene-3-carboxylate
CAS 495386-42-0C20H23NO4S
Ethyl 4-(4-methylphenyl)-2-(oxolan-2-ylcarbonylamino)thiophene-3-carboxylate chemical structure, C19H21NO4S, CAS 379243-21-7
Ethyl 4-(4-methylphenyl)-2-(oxolan-2-ylcarbonylamino)thiophene-3-carboxylate
CAS 379243-21-7C19H21NO4S