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Murcko scaffold

Ring system with 3 rings and 18 atoms

29 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
29
With full pages
6
Scaffold SMILES

C(=Cc1nc(-c2ccccc2)cs1)c1ccco1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C(=Cc1nc(-c2ccccc2)cs1)c1ccco1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

(E)-2-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-3-(2-furyl)-2-propenenitrile chemical structure, C16H9ClN2OS
(E)-2-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-3-(2-furyl)-2-propenenitrile
C16H9ClN2OS
2-[4-(4-Ethoxyphenyl)-1,3-thiazol-2-yl]-3-(furan-2-yl)prop-2-enenitrile chemical structure, C18H14N2O2S, CAS 313687-31-9
2-[4-(4-Ethoxyphenyl)-1,3-thiazol-2-yl]-3-(furan-2-yl)prop-2-enenitrile
CAS 313687-31-9C18H14N2O2S
2-[4-(4-Butyl-phenyl)-thiazol-2-yl]-3-furan-2-yl-acrylonitrile chemical structure, C20H18N2OS, CAS 5212-29-3
2-[4-(4-Butyl-phenyl)-thiazol-2-yl]-3-furan-2-yl-acrylonitrile
CAS 5212-29-3C20H18N2OS
(2E)-3-(Furan-2-yl)-2-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]prop-2-enenitrile chemical structure, C17H12N2O2S, CAS 313687-30-8
(2E)-3-(Furan-2-yl)-2-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]prop-2-enenitrile
CAS 313687-30-8C17H12N2O2S
(Z)-2-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-3-(5-methylfuran-2-yl)prop-2-enenitrile chemical structure, C17H11ClN2OS, CAS 332175-21-0
(Z)-2-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-3-(5-methylfuran-2-yl)prop-2-enenitrile
CAS 332175-21-0C17H11ClN2OS
(2E)-2-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]-3-(furan-2-yl)prop-2-enenitrile chemical structure, C16H9FN2OS, CAS 298219-43-9
(2E)-2-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]-3-(furan-2-yl)prop-2-enenitrile
CAS 298219-43-9C16H9FN2OS
(Z)-2-(4-(3,4-Dichlorophenyl)thiazol-2-yl)-3-(5-methylfuran-2-yl)acrylonitrile chemical structure, C17H10Cl2N2OS, CAS 306288-63-1
(Z)-2-(4-(3,4-Dichlorophenyl)thiazol-2-yl)-3-(5-methylfuran-2-yl)acrylonitrile
CAS 306288-63-1C17H10Cl2N2OS
(Z)-2-(4-(2,4-Dimethylphenyl)thiazol-2-yl)-3-(5-methylfuran-2-yl)acrylonitrile chemical structure, C19H16N2OS, CAS 306288-83-5
(Z)-2-(4-(2,4-Dimethylphenyl)thiazol-2-yl)-3-(5-methylfuran-2-yl)acrylonitrile
CAS 306288-83-5C19H16N2OS
(2E)-2-[4-(2,4-Dichlorophenyl)-1,3-thiazol-2-yl]-3-(furan-2-yl)prop-2-enenitrile chemical structure, C16H8Cl2N2OS, CAS 326915-25-7
(2E)-2-[4-(2,4-Dichlorophenyl)-1,3-thiazol-2-yl]-3-(furan-2-yl)prop-2-enenitrile
CAS 326915-25-7C16H8Cl2N2OS
(E)-2-(4-(3,4-Dichlorophenyl)thiazol-2-yl)-3-(furan-2-yl)acrylonitrile chemical structure, C16H8Cl2N2OS, CAS 332175-19-6
(E)-2-(4-(3,4-Dichlorophenyl)thiazol-2-yl)-3-(furan-2-yl)acrylonitrile
CAS 332175-19-6C16H8Cl2N2OS
3-Furan-2-yl-2-(4-phenyl-thiazol-2-yl)-acrylonitrile chemical structure, C16H10N2OS, CAS 277308-31-3
3-Furan-2-yl-2-(4-phenyl-thiazol-2-yl)-acrylonitrile
CAS 277308-31-3C16H10N2OS
(2E)-2-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-3-(furan-2-yl)prop-2-enenitrile chemical structure, C16H9ClN2OS, CAS 312758-25-1
(2E)-2-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-3-(furan-2-yl)prop-2-enenitrile
CAS 312758-25-1C16H9ClN2OS
3-(Furan-2-yl)-2-(4-(3-methoxyphenyl)thiazol-2-yl)acrylonitrile chemical structure, C17H12N2O2S
3-(Furan-2-yl)-2-(4-(3-methoxyphenyl)thiazol-2-yl)acrylonitrile
C17H12N2O2S
(E)-3-(5-Nitrofuran-2-yl)-2-(4-phenylthiazol-2-yl)acrylonitrile chemical structure, C16H9N3O3S, CAS 303786-02-9
(E)-3-(5-Nitrofuran-2-yl)-2-(4-phenylthiazol-2-yl)acrylonitrile
CAS 303786-02-9C16H9N3O3S
(Z)-2-(4-(4-Chlorophenyl)thiazol-2-yl)-3-(furan-2-yl)acrylonitrile chemical structure, C16H9ClN2OS
(Z)-2-(4-(4-Chlorophenyl)thiazol-2-yl)-3-(furan-2-yl)acrylonitrile
C16H9ClN2OS
(Z)-2-(4-(3-Bromophenyl)thiazol-2-yl)-3-(5-methylfuran-2-yl)acrylonitrile chemical structure, C17H11BrN2OS, CAS 423739-55-3
(Z)-2-(4-(3-Bromophenyl)thiazol-2-yl)-3-(5-methylfuran-2-yl)acrylonitrile
CAS 423739-55-3C17H11BrN2OS
(2Z)-2-[4-(2,4-Dichlorophenyl)-1,3-thiazol-2-yl]-3-(5-methylfuran-2-yl)prop-2-enenitrile chemical structure, C17H10Cl2N2OS, CAS 423738-04-9
(2Z)-2-[4-(2,4-Dichlorophenyl)-1,3-thiazol-2-yl]-3-(5-methylfuran-2-yl)prop-2-enenitrile
CAS 423738-04-9C17H10Cl2N2OS
(2Z)-3-(5-Methylfuran-2-yl)-2-{4-[4-(2-methylpropyl)phenyl]-1,3-thiazol-2-yl}prop-2-enenitrile chemical structure, C21H20N2OS, CAS 476674-90-5
(2Z)-3-(5-Methylfuran-2-yl)-2-{4-[4-(2-methylpropyl)phenyl]-1,3-thiazol-2-yl}prop-2-enenitrile
CAS 476674-90-5C21H20N2OS
(Z)-2-(4-(3,4-Dimethoxyphenyl)thiazol-2-yl)-3-(5-methylfuran-2-yl)acrylonitrile chemical structure, C19H16N2O3S, CAS 423736-17-8
(Z)-2-(4-(3,4-Dimethoxyphenyl)thiazol-2-yl)-3-(5-methylfuran-2-yl)acrylonitrile
CAS 423736-17-8C19H16N2O3S
(2Z)-3-(5-Methylfuran-2-yl)-2-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]prop-2-enenitrile chemical structure, C17H11N3O3S, CAS 423736-36-1
(2Z)-3-(5-Methylfuran-2-yl)-2-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]prop-2-enenitrile
CAS 423736-36-1C17H11N3O3S
(2Z)-2-[4-(3-Methoxyphenyl)-1,3-thiazol-2-yl]-3-(5-methylfuran-2-yl)prop-2-enenitrile chemical structure, C18H14N2O2S, CAS 423735-18-6
(2Z)-2-[4-(3-Methoxyphenyl)-1,3-thiazol-2-yl]-3-(5-methylfuran-2-yl)prop-2-enenitrile
CAS 423735-18-6C18H14N2O2S
(2Z)-3-(Furan-2-yl)-2-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]prop-2-enenitrile chemical structure, C16H9N3O3S, CAS 476675-00-0
(2Z)-3-(Furan-2-yl)-2-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]prop-2-enenitrile
CAS 476675-00-0C16H9N3O3S
(Z)-3-(Furan-2-yl)-2-(4-(3-methoxyphenyl)thiazol-2-yl)acrylonitrile chemical structure, C17H12N2O2S, CAS 476675-06-6
(Z)-3-(Furan-2-yl)-2-(4-(3-methoxyphenyl)thiazol-2-yl)acrylonitrile
CAS 476675-06-6C17H12N2O2S
(2Z)-2-[4-(3,4-Dimethylphenyl)-1,3-thiazol-2-yl]-3-(furan-2-yl)prop-2-enenitrile chemical structure, C18H14N2OS, CAS 476674-83-6
(2Z)-2-[4-(3,4-Dimethylphenyl)-1,3-thiazol-2-yl]-3-(furan-2-yl)prop-2-enenitrile
CAS 476674-83-6C18H14N2OS