Murcko scaffold
1-(2-Phenoxyethyl)piperazine scaffold
238 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 15
- Chemicals
- 238
- With full pages
- 14
Scaffold SMILES
c1ccc(OCCN2CCNCC2)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 49 to 96 of 238 chemicals
![1-[2-(4-Iodophenoxy)ethyl]-4-methylpiperazine chemical structure, C13H19IN2O, CAS 401502-41-8](/s/CPGNYRUJHOCIGZ-UHFFFAOYSA-N.svg)
1-[2-(4-Iodophenoxy)ethyl]-4-methylpiperazine
CAS 401502-41-8C13H19IN2O
![1-[2-(2-Chlorophenoxy)ethyl]piperazine hydrochloride chemical structure, C12H18Cl2N2O, CAS 1048649-18-8](/s/OABPAAXTVPWCGD-UHFFFAOYSA-N.svg)
1-[2-(2-Chlorophenoxy)ethyl]piperazine hydrochloride
CAS 1048649-18-8C12H18Cl2N2O
![1-[2-(2,4-Dichlorophenoxy)ethyl]piperazine hydrochloride chemical structure, C12H17Cl3N2O, CAS 1050126-69-6](/s/WDOREYKBCRZLNE-UHFFFAOYSA-N.svg)
1-[2-(2,4-Dichlorophenoxy)ethyl]piperazine hydrochloride
CAS 1050126-69-6C12H17Cl3N2O
![4-[2-(4-Ethyl-piperazin-1-yl)-ethoxy]-phenylamine chemical structure, C14H23N3O, CAS 946736-04-5](/s/CBIUHNVXMPGTQP-UHFFFAOYSA-N.svg)
4-[2-(4-Ethyl-piperazin-1-yl)-ethoxy]-phenylamine
CAS 946736-04-5C14H23N3O
![4-[2-(1-Piperazinyl)ethoxy]aniline chemical structure, C12H19N3O, CAS 946689-19-6](/s/IXMQTVDBPAJUSW-UHFFFAOYSA-N.svg)
4-[2-(1-Piperazinyl)ethoxy]aniline
CAS 946689-19-6C12H19N3O
![2-[2-(Piperazin-1-yl)ethoxy]aniline chemical structure, C12H19N3O, CAS 946736-07-8](/s/PBDHVZNSNILPMS-UHFFFAOYSA-N.svg)
2-[2-(Piperazin-1-yl)ethoxy]aniline
CAS 946736-07-8C12H19N3O
![4-[2-(4-Ethyl-1-piperazinyl)ethoxy]benzaldehyde chemical structure, C15H22N2O2, CAS 915922-53-1](/s/NKJUABQRXOGQKI-UHFFFAOYSA-N.svg)
4-[2-(4-Ethyl-1-piperazinyl)ethoxy]benzaldehyde
CAS 915922-53-1C15H22N2O2
![4-[2-(4-Ethyl-1-piperazinyl)ethoxy]-3-methoxybenzaldehyde chemical structure, C16H24N2O3, CAS 937691-09-3](/s/RRYDWIGFFWCRAM-UHFFFAOYSA-N.svg)
4-[2-(4-Ethyl-1-piperazinyl)ethoxy]-3-methoxybenzaldehyde
CAS 937691-09-3C16H24N2O3
![2-[2-(4-Ethyl-1-piperazinyl)ethoxy]benzaldehyde chemical structure, C15H22N2O2, CAS 915920-88-6](/s/ILFIJVXRLNLGLC-UHFFFAOYSA-N.svg)
2-[2-(4-Ethyl-1-piperazinyl)ethoxy]benzaldehyde
CAS 915920-88-6C15H22N2O2
![tert-Butyl 4-[2-(3-formylphenoxy)ethyl]tetrahydro-1(2H)-pyrazinecarboxylate chemical structure, C18H26N2O4, CAS 924869-28-3](/s/LZNLSDIAHAWVSZ-UHFFFAOYSA-N.svg)
tert-Butyl 4-[2-(3-formylphenoxy)ethyl]tetrahydro-1(2H)-pyrazinecarboxylate
CAS 924869-28-3C18H26N2O4
Methyl 4-(2-piperazinoethoxy)benzenecarboxylate hydrochloride
CAS 1170473-34-3C14H21ClN2O3
![1-[2-(3-Nitrophenoxy)ethyl]piperazine chemical structure, C12H17N3O3, CAS 1240565-07-4](/s/STPCZHVOQVIBAL-UHFFFAOYSA-N.svg)
1-[2-(3-Nitrophenoxy)ethyl]piperazine
CAS 1240565-07-4C12H17N3O3
![1-[2-(4-Nitrophenoxy)ethyl]piperazine dihydrochloride chemical structure, C12H19Cl2N3O3, CAS 2040007-00-7](/s/AVXSXOCJDBVVGE-UHFFFAOYSA-N.svg)
1-[2-(4-Nitrophenoxy)ethyl]piperazine dihydrochloride
CAS 2040007-00-7C12H19Cl2N3O3
![3-Methoxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]aniline chemical structure, C14H23N3O2, CAS 835633-55-1](/s/QUICNJMNPNNIIX-UHFFFAOYSA-N.svg)
3-Methoxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]aniline
CAS 835633-55-1C14H23N3O2
![3,4-Dimethoxy-5-[2-(4-methyl-piperazin-1-yl)-ethoxy]-phenylamine chemical structure, C15H25N3O3, CAS 700804-42-8](/s/JRVSCFCAKPPNCD-UHFFFAOYSA-N.svg)
3,4-Dimethoxy-5-[2-(4-methyl-piperazin-1-yl)-ethoxy]-phenylamine
CAS 700804-42-8C15H25N3O3
![2-[2-(Piperazin-1-yl)ethoxy]benzonitrile chemical structure, C13H17N3O, CAS 552336-64-8](/s/KXKUMYVAUIKHME-UHFFFAOYSA-N.svg)
2-[2-(Piperazin-1-yl)ethoxy]benzonitrile
CAS 552336-64-8C13H17N3O
![1-[2-(3-Fluorophenoxy)ethyl]piperazine chemical structure, C12H17FN2O, CAS 1082434-97-6](/s/WHUHZURNDSVIQB-UHFFFAOYSA-N.svg)
1-[2-(3-Fluorophenoxy)ethyl]piperazine
CAS 1082434-97-6C12H17FN2O
![2-[2-(4-Methylpiperazin-1-yl)ethoxy]aniline chemical structure, C13H21N3O, CAS 937689-61-7](/s/YSKLCWCAHUOZGG-UHFFFAOYSA-N.svg)
2-[2-(4-Methylpiperazin-1-yl)ethoxy]aniline
CAS 937689-61-7C13H21N3O
![3-[2-(4-Methyl-1-piperazinyl)ethoxy]benzenamine chemical structure, C13H21N3O, CAS 890652-00-3](/s/OCLILGBSWCUZDJ-UHFFFAOYSA-N.svg)
3-[2-(4-Methyl-1-piperazinyl)ethoxy]benzenamine
CAS 890652-00-3C13H21N3O
![4-[2-(4-Methylpiperazin-1-yl)ethoxy]aniline chemical structure, C13H21N3O, CAS 38948-28-6](/s/PODGLCSJCBYFGC-UHFFFAOYSA-N.svg)
4-[2-(4-Methylpiperazin-1-yl)ethoxy]aniline
CAS 38948-28-6C13H21N3O
4-(2-(Piperazin-1-yl)ethoxy)benzoic acid
CAS 401804-58-8C13H18N2O3
![2-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-benzoicacid chemical structure, C14H20N2O3, CAS 401804-46-4](/s/CETIEYKHHXZMCF-UHFFFAOYSA-N.svg)
2-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-benzoicacid
CAS 401804-46-4C14H20N2O3
![4-[2-(4-Aminophenoxy)ethyl]-1-piperazineethanol chemical structure, C14H23N3O2, CAS 937696-02-1](/s/PIJBITAEJMKOAN-UHFFFAOYSA-N.svg)
4-[2-(4-Aminophenoxy)ethyl]-1-piperazineethanol
CAS 937696-02-1C14H23N3O2
1-(2-(4-Bromophenoxy)ethyl)piperazine
CAS 103541-03-3C12H17BrN2O
- 1-[2-(2-Methylphenoxy)ethyl]piperazine dihydrochloride479669-59-5C13H22Cl2N2O
- Piperazine, 1-[2-(3-methylphenoxy)ethyl]-, hydrochloride (1:2)479669-60-8C13H22Cl2N2O
- 1-[2-(4-Methoxyphenoxy)ethyl]piperazine dihydrochloride479669-62-0C13H22Cl2N2O2
- 1-[2-(2-Ethylphenoxy)ethyl]piperazine401485-32-3C14H22N2O
- tert-Butyl 4-[2-(4-Formylphenoxy)ethyl]piperazine-1-carboxylate1086378-39-3C18H26N2O4
- tert-Butyl 4-(2-(3-nitrophenoxy)ethyl)piperazine-1-carboxylate1135283-71-4C17H25N3O5
- tert-Butyl 4-[2-(3-aminophenoxy)ethyl]piperazine-1-carboxylate1135283-72-5C17H27N3O3
- 3-[2-(4-Acetylpiperazin-1-yl)ethoxy]benzaldehyde1176548-69-8C15H20N2O3
- 2-Methyl-4-[2-(4-methylpiperazinyl)ethoxy]aniline1181364-85-1C14H23N3O
- 1-(4-{2-[4-(2-Aminoethyl)phenoxy]ethyl}piperazin-1-yl)ethan-1-one1094860-51-1C16H25N3O2
- 2-(4-{2-[4-(2-Aminoethyl)phenoxy]ethyl}piperazin-1-yl)ethan-1-ol1157004-09-5C16H27N3O2
- 4-(2-(3-Methylpiperazin-1-yl)ethoxy)benzonitrile1185323-88-9C14H19N3O
- 1-[2-(3-Bromophenoxy)ethyl]piperazine dihydrochloride1193388-83-8C12H19BrCl2N2O
- 1-[2-(4-Chlorophenoxy)ethyl]-4-(prop-2-yn-1-yl)piperazine1197709-60-6C15H19ClN2O
- Ethyl 4-[2-(2-chlorophenoxy)ethyl]-1-piperazinecarboxylate1209286-57-6C15H21ClN2O3
- 1-[2-(2-Isopropyl-5-methyl-phenoxy)-ethyl]-piperazine dihydrochloride1185300-15-5C16H28Cl2N2O
- 1-[2-(3-Chloro-phenoxy)-ethyl]-piperazine dihydrochloride1185300-23-5C12H19Cl3N2O
- 1-(2-(2-Chlorophenoxy)ethyl)-3-methylpiperazine1241170-75-1C13H19ClN2O
- 1-[2-(3-Chlorophenoxy)ethyl]-2-methylpiperazine1240572-62-6C13H19ClN2O
- 4-[2-{4-(tert-Butyloxycarbonyl)piperazin-1-yl}ethoxy]benzoic acid1216502-34-9C18H26N2O5
- Ethyl 4-{2-[4-(tert-Butoxycarbonyl)piperazin-1-yl]ethoxy}benzoate1216410-07-9C20H30N2O5
- 1-[2-(2-Bromophenoxy)ethyl]-4-methylpiperazine401482-42-6C13H19BrN2O
- 1-(2-Phenoxyethyl)-4-(prop-2-yn-1-yl)piperazine1281052-13-8C15H20N2O
- 1-(2-Ethoxyethyl)-4-[2-(4-methoxyphenoxy)ethyl]piperazine918481-63-7C17H28N2O3
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1ccccc1)Nc1ccccc1421 chemicals
O=C(C=Cc1ccccc1)c1ccccc1389 chemicals
O=C(NCc1ccccc1)c1ccccc1260 chemicals
O=C(Cc1ccccc1)Nc1ccccc1219 chemicals
O=S(=O)(NCc1ccccc1)c1ccccc1164 chemicals
c1ccc(CNCc2ccccc2)cc1142 chemicals
S=C(Nc1ccccc1)Nc1ccccc1109 chemicals
O=C(CCc1ccccc1)c1ccccc187 chemicals
C(=NNc1ccccc1)c1ccccc173 chemicals
O=C(Nc1ccccc1)Oc1ccccc173 chemicals
O=C(OCc1ccccc1)N1CCCCC161 chemicals
O=C(OCc1ccccc1)c1ccccc157 chemicals