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Murcko scaffold

Spiro-[2.5]octan-6-one scaffold

41 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
9
Chemicals
41
With full pages
8
Scaffold SMILES

O=C1CCC2(CC1)CC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Spiro-[2.5]octan-6-one page
Murcko scaffold O=C1CCC2(CC1)CC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 41 of 41 chemicals

Spiro-[2.5]octan-6-one chemical structure, C8H12O, CAS 15811-21-9
Spiro-[2.5]octan-6-one
CAS 15811-21-9C8H12O
Ethyl 6-oxospiro[2.5]octane-5-carboxylate chemical structure, C11H16O3, CAS 956079-08-6
Ethyl 6-oxospiro[2.5]octane-5-carboxylate
CAS 956079-08-6C11H16O3
1-Aminospiro[2.5]octan-6-one chemical structure, C8H13NO, CAS 1780406-43-0
1-Aminospiro[2.5]octan-6-one
CAS 1780406-43-0C8H13NO
6-Oxospiro[2.5]octane-1-carboxylic acid chemical structure, C9H12O3, CAS 1782521-95-2
6-Oxospiro[2.5]octane-1-carboxylic acid
CAS 1782521-95-2C9H12O3
tert-Butyl N-{6-oxospiro[2.5]octan-1-yl}carbamate chemical structure, C13H21NO3, CAS 1784627-63-9
tert-Butyl N-{6-oxospiro[2.5]octan-1-yl}carbamate
CAS 1784627-63-9C13H21NO3
Ethyl 6-oxospiro[2.5]octane-1-carboxylate chemical structure, C11H16O3, CAS 1447942-87-1
Ethyl 6-oxospiro[2.5]octane-1-carboxylate
CAS 1447942-87-1C11H16O3
6-Oxospiro[2.5]octane-5-carbonitrile chemical structure, C9H11NO, CAS 1428757-72-5
6-Oxospiro[2.5]octane-5-carbonitrile
CAS 1428757-72-5C9H11NO
5-Aminospiro[2.5]octan-6-one chemical structure, C8H13NO, CAS 1803571-88-1
5-Aminospiro[2.5]octan-6-one
CAS 1803571-88-1C8H13NO
1,1-Difluorospiro(2.5)octan-6-one chemical structure, C8H10F2O, CAS 1513853-81-0
1,1-Difluorospiro(2.5)octan-6-one
CAS 1513853-81-0C8H10F2O
Methyl 6-oxospiro(2.5)octane-1-carboxylate chemical structure, C10H14O3, CAS 1590372-46-5
Methyl 6-oxospiro(2.5)octane-1-carboxylate
CAS 1590372-46-5C10H14O3
6-Oxospiro[2.5]octane-5-carbaldehyde chemical structure, C9H12O2, CAS 1996275-50-3
6-Oxospiro[2.5]octane-5-carbaldehyde
CAS 1996275-50-3C9H12O2
5-Propanoylspiro[2.5]octan-6-one chemical structure, C11H16O2, CAS 2012223-27-5
5-Propanoylspiro[2.5]octan-6-one
CAS 2012223-27-5C11H16O2
Ethyl 2-(1,1-difluoro-6-oxospiro[2.5]octan-5-yl)-2-oxoacetate chemical structure, C12H14F2O4, CAS 2060591-41-3
Ethyl 2-(1,1-difluoro-6-oxospiro[2.5]octan-5-yl)-2-oxoacetate
CAS 2060591-41-3C12H14F2O4
Ethyl 2-oxo-2-(6-oxospiro[2.5]octan-5-yl)acetate chemical structure, C12H16O4, CAS 2001748-64-5
Ethyl 2-oxo-2-(6-oxospiro[2.5]octan-5-yl)acetate
CAS 2001748-64-5C12H16O4
1,1-Difluoro-2-methylspiro[2.5]octan-6-one chemical structure, C9H12F2O, CAS 2098030-42-1
1,1-Difluoro-2-methylspiro[2.5]octan-6-one
CAS 2098030-42-1C9H12F2O
1,1-Difluoro-2-(propan-2-yl)spiro[2.5]octan-6-one chemical structure, C11H16F2O, CAS 2098063-38-6
1,1-Difluoro-2-(propan-2-yl)spiro[2.5]octan-6-one
CAS 2098063-38-6C11H16F2O
2-Ethyl-1,1-difluorospiro[2.5]octan-6-one chemical structure, C10H14F2O, CAS 2098019-52-2
2-Ethyl-1,1-difluorospiro[2.5]octan-6-one
CAS 2098019-52-2C10H14F2O
1,1-Difluoro-2-(methoxymethyl)spiro[2.5]octan-6-one chemical structure, C10H14F2O2, CAS 2098115-15-0
1,1-Difluoro-2-(methoxymethyl)spiro[2.5]octan-6-one
CAS 2098115-15-0C10H14F2O2
Ethyl 2-{2,2-difluoro-6-oxospiro[2.5]octan-1-yl}acetate chemical structure, C12H16F2O3, CAS 2098128-76-6
Ethyl 2-{2,2-difluoro-6-oxospiro[2.5]octan-1-yl}acetate
CAS 2098128-76-6C12H16F2O3
5-Fluorospiro[2.5]octan-6-one chemical structure, C8H11FO, CAS 2059954-96-8
5-Fluorospiro[2.5]octan-6-one
CAS 2059954-96-8C8H11FO
6-Oxospiro[2.5]octane-1-carbonitrile chemical structure, C9H11NO, CAS 2091273-94-6
6-Oxospiro[2.5]octane-1-carbonitrile
CAS 2091273-94-6C9H11NO
Methyl 6-oxospiro[2.5]octane-5-carboxylate chemical structure, C10H14O3, CAS 2012890-04-7
Methyl 6-oxospiro[2.5]octane-5-carboxylate
CAS 2012890-04-7C10H14O3
tert-Butyl N-({6-oxospiro[2.5]octan-1-yl}methyl)carbamate chemical structure, C14H23NO3, CAS 2253632-77-6
tert-Butyl N-({6-oxospiro[2.5]octan-1-yl}methyl)carbamate
CAS 2253632-77-6C14H23NO3
5-Bromospiro[2.5]octan-6-one chemical structure, C8H11BrO, CAS 2375269-65-9
5-Bromospiro[2.5]octan-6-one
CAS 2375269-65-9C8H11BrO