Murcko scaffold
Spiro(2,5)octane scaffold
474 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 8
- Chemicals
- 474
- With full pages
- 63
Scaffold SMILES
C1CCC2(CC1)CC2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 474 chemicals
Spiro(2,5)octane
CAS 185-65-9C8H14
Spiro(2.5)octane-1,1,2,2-tetracarbonitrile
CAS 10432-36-7C12H10N4
4-Methylspiro(2.5)octane-1,1,2,2-tetracarbonitrile
CAS 10566-02-6C13H12N4
![Spiro[2.5]octan-4-ol chemical structure, C8H14O, CAS 3301-81-3](/s/CDPOAAXJDYXYCR-UHFFFAOYSA-N.svg)
Spiro[2.5]octan-4-ol
CAS 3301-81-3C8H14O
![(S)-Spiro[2.5]octane-1-carboxamide chemical structure, C9H15NO, CAS 680619-58-3](/s/HDQONKBOIFNIBM-SSDOTTSWSA-N.svg)
(S)-Spiro[2.5]octane-1-carboxamide
CAS 680619-58-3C9H15NO
![1-(Aminomethyl)spiro[2.5]octane-1-carboxylic acid chemical structure, C10H17NO2, CAS 724772-97-8](/s/NZSUXZDGKUBVPB-UHFFFAOYSA-N.svg)
1-(Aminomethyl)spiro[2.5]octane-1-carboxylic acid
CAS 724772-97-8C10H17NO2
![1-(Aminomethyl)spiro[2.5]octane-1-carboxylic acid hydrochloride chemical structure, C10H18ClNO2, CAS 724773-58-4](/s/AVKRCQDGYZQPAA-UHFFFAOYSA-N.svg)
1-(Aminomethyl)spiro[2.5]octane-1-carboxylic acid hydrochloride
CAS 724773-58-4C10H18ClNO2
![6-tert-Butylspiro[2.5]octane-1-carboxylic acid chemical structure, C13H22O2, CAS 680619-06-1](/s/WJNZKHUYAGCEOU-UHFFFAOYSA-N.svg)
6-tert-Butylspiro[2.5]octane-1-carboxylic acid
CAS 680619-06-1C13H22O2
![(R)-Spiro[2.5]octane-1-carboxamide chemical structure, C9H15NO, CAS 680619-59-4](/s/HDQONKBOIFNIBM-ZETCQYMHSA-N.svg)
(R)-Spiro[2.5]octane-1-carboxamide
CAS 680619-59-4C9H15NO
![(S)-Spiro[2.5]octane-1-carboxylic acid chemical structure, C9H14O2, CAS 680618-94-4](/s/MWCFUPYBGQILOY-SSDOTTSWSA-N.svg)
(S)-Spiro[2.5]octane-1-carboxylic acid
CAS 680618-94-4C9H14O2
Abt-769
CAS 680618-97-7C11H18N2O2
![(R)-Spiro[2.5]octane-1-carboxylic acid chemical structure, C9H14O2, CAS 680618-96-6](/s/MWCFUPYBGQILOY-ZETCQYMHSA-N.svg)
(R)-Spiro[2.5]octane-1-carboxylic acid
CAS 680618-96-6C9H14O2
![Methyl 1-aminospiro[2.5]octane-1-carboxylate chemical structure, C10H17NO2, CAS 159279-80-8](/s/XZCKEGBTWCATGN-UHFFFAOYSA-N.svg)
Methyl 1-aminospiro[2.5]octane-1-carboxylate
CAS 159279-80-8C10H17NO2
Spiro(2.5)octane-1-carboxylic Acid
CAS 17202-86-7C9H14O2
![Spiro[2.5]octan-2-ol chemical structure, C8H14O, CAS 90112-48-4](/s/BFJLGHJGJYFISZ-UHFFFAOYSA-N.svg)
Spiro[2.5]octan-2-ol
CAS 90112-48-4C8H14O
![Spiro[2.5]octane-1-carbaldehyde chemical structure, C9H14O, CAS 200055-26-1](/s/MFIZELFJJZOMGP-UHFFFAOYSA-N.svg)
Spiro[2.5]octane-1-carbaldehyde
CAS 200055-26-1C9H14O
![Ethyl Spiro[2.5]octane-1-carboxylate chemical structure, C11H18O2, CAS 17202-87-8](/s/LXTLLTTUBHRRGO-UHFFFAOYSA-N.svg)
Ethyl Spiro[2.5]octane-1-carboxylate
CAS 17202-87-8C11H18O2
![1-(((tert-Butoxycarbonyl)amino)methyl)spiro[2.5]octane-1-carboxylic acid chemical structure, C15H25NO4, CAS 724773-53-9](/s/PEBPJTABRARMEU-UHFFFAOYSA-N.svg)
1-(((tert-Butoxycarbonyl)amino)methyl)spiro[2.5]octane-1-carboxylic acid
CAS 724773-53-9C15H25NO4
![1-Aminospiro[2.5]octane-1-carboxylic acid chemical structure, C9H15NO2, CAS 159279-82-0](/s/XEXRZNWICRUDIT-UHFFFAOYSA-N.svg)
1-Aminospiro[2.5]octane-1-carboxylic acid
CAS 159279-82-0C9H15NO2
![(8S)-Spiro[2.5]octan-8-ol chemical structure, C8H14O, CAS 110793-78-7](/s/CDPOAAXJDYXYCR-ZETCQYMHSA-N.svg)
(8S)-Spiro[2.5]octan-8-ol
CAS 110793-78-7C8H14O
![Methyl 2-[(trimethylsilyl)oxy]spiro[2.5]octane-1-carboxylate chemical structure, C13H24O3Si, CAS 82884-41-1](/s/VFSUANFRMDRJIT-UHFFFAOYSA-N.svg)
Methyl 2-[(trimethylsilyl)oxy]spiro[2.5]octane-1-carboxylate
CAS 82884-41-1C13H24O3Si
![Spiro[2.5]octane-1,2-dicarboxylic acid chemical structure, C10H14O4, CAS 90927-27-8](/s/HAJBDAKAEJHSED-UHFFFAOYSA-N.svg)
Spiro[2.5]octane-1,2-dicarboxylic acid
CAS 90927-27-8C10H14O4
![Trimethyl[(5-methylspiro[2.5]octan-4-yl)oxy]silane chemical structure, C12H24OSi, CAS 88982-04-1](/s/OXPFOTFQVGHSQY-UHFFFAOYSA-N.svg)
Trimethyl[(5-methylspiro[2.5]octan-4-yl)oxy]silane
CAS 88982-04-1C12H24OSi
![6-Ethylspiro[2.5]octane chemical structure, C10H18, CAS 105786-53-6](/s/PNSADXNZUWCLQX-UHFFFAOYSA-N.svg)
6-Ethylspiro[2.5]octane
CAS 105786-53-6C10H18
- 6,6-Dimethylspiro[2.5]octane105786-54-7C10H18
- Trimethyl[(spiro[2.5]octan-4-yl)oxy]silane66629-04-7C11H22OSi
- 7,7-Dimethylspiro[2.5]octan-5-amine226549-57-1C10H19N
- 1,1-Difluorospiro[2.5]octane59987-85-8C8H12F2
- Spiro[2.5]octan-1-ylmethanamine938458-82-3C9H17N
- Spiro[2.5]octan-6-ylmethanamine877201-35-9C9H17N
- 6-Methylspiro[2.5]octanecarboxylic acid1249369-92-3C10H16O2
- 6-tert-Butylspiro[2.5]octan-1-amine1248798-85-7C12H23N
- Spiro[2.5]octan-1-amine17202-90-3C8H15N
- 1 suppliersSpiro[2.5]octane-6-carboxylic acid1086399-13-4C9H14O2
- Spiro[2.5]octan-6-amine99799-73-2C8H15N
- (Spiro(2.5)octan-6-yl)methanol849671-56-3C9H16O
- Spiro[2.5]octan-6-ol22428-83-7C8H14O
- Ethyl 1-cyanospiro[2.5]octane-1-carboxylate724773-39-1C12H17NO2
- 6-(2-Methylbutan-2-yl)spiro(2.5)octane-1-carboxylic acid1271659-84-7C14H24O2
- Spiro[2.5]octan-4-amine78293-96-6C8H15N
- Methyl-spiro[2.5]oct-6-ylmethylamine877125-97-8C10H19N
- Spiro[2.5]octane-4-carbaldehyde919482-27-2C9H14O
- Spiro[2.5]octan-5-amine1228531-38-1C8H15N
- tert-Butyl spiro[2.5]octan-6-ylcarbamate1256256-52-6C13H23NO2
- 6-(Propan-2-yl)spiro[2.5]octan-1-amine1342293-01-9C11H21N
- [6-(Propan-2-yl)spiro[2.5]octan-1-yl]methanamine1343619-11-3C12H23N
- 6,6-Dimethylspiro[2.5]octane-1-carboxylic acid1340573-53-6C11H18O2
- 6,6-Dimethylspiro[2.5]octan-1-amine1341573-26-9C10H19N
Related scaffolds
Same ring framework with different atoms or bond orders
C1CC2(CCN1)CC234 chemicals
C1CC2(CCO1)CC222 chemicals
C1CCC2(CC2)NC120 chemicals
C1CNCC2(C1)CC220 chemicals
C1CCC2(CC1)CO210 chemicals
O=C1CCC2(CC1)CC28 chemicals
C1CNC2(CC2)CN18 chemicals
C1COCC2(CC2)N18 chemicals
C1CCC2(CC1)N=N26 chemicals
C1CC2(CCN1)N=N23 chemicals
O=S1(=O)CCC2(CC2)CC13 chemicals
C1COCC2(C1)CC23 chemicals