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Murcko scaffold

Ring system with 2 rings and 15 atoms

68 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
68
With full pages
14
Scaffold SMILES

O=C1CSC(NN=Cc2ccccc2)=N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CSC(NN=Cc2ccccc2)=N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 68 chemicals

4(5H)-Thiazolone, 5-ethyl-2-(1-methyl-2-(phenylmethylene)hydrazino)- chemical structure, C13H15N3OS, CAS 34547-33-6
4(5H)-Thiazolone, 5-ethyl-2-(1-methyl-2-(phenylmethylene)hydrazino)-
CAS 34547-33-6C13H15N3OS
2-[(2E)-2-[(4-Nitrophenyl)methylidene]hydrazinyl]-1,3-thiazol-4-one chemical structure, C10H8N4O3S, CAS 93691-33-9
2-[(2E)-2-[(4-Nitrophenyl)methylidene]hydrazinyl]-1,3-thiazol-4-one
CAS 93691-33-9C10H8N4O3S
2-{(2E)-2-[(2E)-(4-Nitrobenzylidene)hydrazinylidene]-4-oxo-1,3-thiazolidin-5-yl}-N-(propan-2-yl)acetamide chemical structure, C15H17N5O4S, CAS 857493-89-1
2-{(2E)-2-[(2E)-(4-Nitrobenzylidene)hydrazinylidene]-4-oxo-1,3-thiazolidin-5-yl}-N-(propan-2-yl)acetamide
CAS 857493-89-1C15H17N5O4S
2-(2-(2-(1-(4-Methoxyphenyl)ethylidene)hydrazinyl)-4-oxo-4,5-dihydrothiazol-5-yl)acetic acid chemical structure, C14H15N3O4S
2-(2-(2-(1-(4-Methoxyphenyl)ethylidene)hydrazinyl)-4-oxo-4,5-dihydrothiazol-5-yl)acetic acid
C14H15N3O4S
2-Hydroxybenzaldehyde (4-oxo-4,5-dihydro-1,3-thiazol-2-yl)hydrazone chemical structure, C10H9N3O2S, CAS 22067-36-3
2-Hydroxybenzaldehyde (4-oxo-4,5-dihydro-1,3-thiazol-2-yl)hydrazone
CAS 22067-36-3C10H9N3O2S
(Z)-2-((E)-(3-Allyl-2-hydroxybenzylidene)hydrazono)thiazolidin-4-one chemical structure, C13H13N3O2S, CAS 324067-00-7
(Z)-2-((E)-(3-Allyl-2-hydroxybenzylidene)hydrazono)thiazolidin-4-one
CAS 324067-00-7C13H13N3O2S
2-((E)-2-((E)-Benzylidenehydrazono)-4-oxothiazolidin-5-yl)acetic acid chemical structure, C12H11N3O3S, CAS 125908-65-8
2-((E)-2-((E)-Benzylidenehydrazono)-4-oxothiazolidin-5-yl)acetic acid
CAS 125908-65-8C12H11N3O3S
(2Z)-2-[(E)-(4-Propan-2-ylphenyl)methylidenehydrazinylidene]-1,3-thiazolidin-4-one chemical structure, C13H15N3OS, CAS 6056-46-8
(2Z)-2-[(E)-(4-Propan-2-ylphenyl)methylidenehydrazinylidene]-1,3-thiazolidin-4-one
CAS 6056-46-8C13H15N3OS
2-[(2E)-2-[(2-Fluorophenyl)methylidene]hydrazinyl]-5-methyl-1,3-thiazol-4-one chemical structure, C11H10FN3OS, CAS 311783-42-3
2-[(2E)-2-[(2-Fluorophenyl)methylidene]hydrazinyl]-5-methyl-1,3-thiazol-4-one
CAS 311783-42-3C11H10FN3OS
2-{2-[(5-Bromo-2-hydroxyphenyl)methylidene]hydrazin-1-yl}-4,5-dihydro-1,3-thiazol-4-one chemical structure, C10H8BrN3O2S
2-{2-[(5-Bromo-2-hydroxyphenyl)methylidene]hydrazin-1-yl}-4,5-dihydro-1,3-thiazol-4-one
C10H8BrN3O2S
4-Hydroxybenzaldehyde (4-oxo-5-propyl-1,3-thiazolidin-2-ylidene)hydrazone chemical structure, C13H15N3O2S, CAS 1089285-33-5
4-Hydroxybenzaldehyde (4-oxo-5-propyl-1,3-thiazolidin-2-ylidene)hydrazone
CAS 1089285-33-5C13H15N3O2S
{2-[(3-Ethoxy-4-hydroxybenzylidene)hydrazono]-4-oxo-1,3-thiazolidin-5-yl}acetic acid chemical structure, C14H15N3O5S, CAS 5948-26-5
{2-[(3-Ethoxy-4-hydroxybenzylidene)hydrazono]-4-oxo-1,3-thiazolidin-5-yl}acetic acid
CAS 5948-26-5C14H15N3O5S
2-[(4-Chloro-benzylidene)-hydrazono]-5-methyl-thiazolidin-4-one chemical structure, C11H10ClN3OS, CAS 103726-44-9
2-[(4-Chloro-benzylidene)-hydrazono]-5-methyl-thiazolidin-4-one
CAS 103726-44-9C11H10ClN3OS
(2E)-2-[(E)-(2,5-Dimethoxyphenyl)methylidenehydrazinylidene]-5-methyl-1,3-thiazolidin-4-one chemical structure, C13H15N3O3S, CAS 5951-21-3
(2E)-2-[(E)-(2,5-Dimethoxyphenyl)methylidenehydrazinylidene]-5-methyl-1,3-thiazolidin-4-one
CAS 5951-21-3C13H15N3O3S
(E)-2-((E)-(4-Methoxybenzylidene)hydrazono)-5-methylthiazolidin-4-one chemical structure, C12H13N3O2S, CAS 103726-45-0
(E)-2-((E)-(4-Methoxybenzylidene)hydrazono)-5-methylthiazolidin-4-one
CAS 103726-45-0C12H13N3O2S
(2-{[1-(4-Methoxyphenyl)ethylidene]hydrazono}-4-oxo-1,3-thiazolidin-5-yl)acetic acid chemical structure, C14H15N3O4S
(2-{[1-(4-Methoxyphenyl)ethylidene]hydrazono}-4-oxo-1,3-thiazolidin-5-yl)acetic acid
C14H15N3O4S
Benzaldehyde, (4,5-dihydro-5-methyl-4-oxo-2-thiazolyl)hydrazone chemical structure, C11H11N3OS, CAS 32003-25-1
Benzaldehyde, (4,5-dihydro-5-methyl-4-oxo-2-thiazolyl)hydrazone
CAS 32003-25-1C11H11N3OS
2-{(2Z)-2-[(2E)-(4-Methoxybenzylidene)hydrazinylidene]-4-oxo-1,3-thiazolidin-5-yl}-N-(propan-2-yl)acetamide chemical structure, C16H20N4O3S, CAS 1322208-45-6
2-{(2Z)-2-[(2E)-(4-Methoxybenzylidene)hydrazinylidene]-4-oxo-1,3-thiazolidin-5-yl}-N-(propan-2-yl)acetamide
CAS 1322208-45-6C16H20N4O3S
2-((E)-2-((E)-Benzylidenehydrazono)-4-oxothiazolidin-5-yl)-N-carbamoylacetamide chemical structure, C13H13N5O3S, CAS 868152-93-6
2-((E)-2-((E)-Benzylidenehydrazono)-4-oxothiazolidin-5-yl)-N-carbamoylacetamide
CAS 868152-93-6C13H13N5O3S
2-[(3,4-Dimethoxybenzylidene)hydrazono] thiazolidin-4-one chemical structure, C12H13N3O3S, CAS 155225-31-3
2-[(3,4-Dimethoxybenzylidene)hydrazono] thiazolidin-4-one
CAS 155225-31-3C12H13N3O3S
{(2Z)-2-[(2E)-(3,4-Dimethoxybenzylidene)hydrazinylidene]-4-oxo-1,3-thiazolidin-5-yl}acetic acid chemical structure, C14H15N3O5S, CAS 321973-99-3
{(2Z)-2-[(2E)-(3,4-Dimethoxybenzylidene)hydrazinylidene]-4-oxo-1,3-thiazolidin-5-yl}acetic acid
CAS 321973-99-3C14H15N3O5S
2-{(E)-2-[(E)-1-Phenylethylidene]hydrazono}-1,3-thiazolan-4-one chemical structure, C11H11N3OS, CAS 115163-95-6
2-{(E)-2-[(E)-1-Phenylethylidene]hydrazono}-1,3-thiazolan-4-one
CAS 115163-95-6C11H11N3OS
3,5-Dichloro-2-hydroxybenzaldehyde (4-oxo-1,3-thiazolidin-2-ylidene)hydrazone chemical structure, C10H7Cl2N3O2S, CAS 5482-27-9
3,5-Dichloro-2-hydroxybenzaldehyde (4-oxo-1,3-thiazolidin-2-ylidene)hydrazone
CAS 5482-27-9C10H7Cl2N3O2S
(2Z)-2-[(2E)-(4-Ethoxybenzylidene)hydrazinylidene]-2,5-dihydro-1,3-thiazol-4-ol chemical structure, C12H13N3O2S, CAS 71299-63-3
(2Z)-2-[(2E)-(4-Ethoxybenzylidene)hydrazinylidene]-2,5-dihydro-1,3-thiazol-4-ol
CAS 71299-63-3C12H13N3O2S