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Murcko scaffold

Nicopholine scaffold

69 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
14
Chemicals
69
With full pages
6
Scaffold SMILES

O=C(c1cccnc1)N1CCOCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Nicopholine page
Murcko scaffold O=C(c1cccnc1)N1CCOCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 69 chemicals

Nicopholine chemical structure, C10H12N2O2, CAS 492-85-3
Nicopholine
CAS 492-85-3C10H12N2O2
(5-Bromo-3-pyridyl)-morpholino-methanone chemical structure, C10H11BrN2O2, CAS 342013-81-4
(5-Bromo-3-pyridyl)-morpholino-methanone
CAS 342013-81-4C10H11BrN2O2
(2,6-Dichloropyridin-3-yl)(morpholino)methanone chemical structure, C10H10Cl2N2O2, CAS 415700-14-0
(2,6-Dichloropyridin-3-yl)(morpholino)methanone
CAS 415700-14-0C10H10Cl2N2O2
4-(6-Chloropyridine-3-carbonyl)morpholine chemical structure, C10H11ClN2O2, CAS 64614-49-9
4-(6-Chloropyridine-3-carbonyl)morpholine
CAS 64614-49-9C10H11ClN2O2
Morpholino{2-[(3,4,4-trifluoro-3-butenyl)sulfanyl]-3-pyridinyl}methanone chemical structure, C14H15F3N2O2S, CAS 478081-12-8
Morpholino{2-[(3,4,4-trifluoro-3-butenyl)sulfanyl]-3-pyridinyl}methanone
CAS 478081-12-8C14H15F3N2O2S
(2-Chloropyridin-3-yl)(morpholin-4-yl)methanone chemical structure, C10H11ClN2O2, CAS 53062-98-9
(2-Chloropyridin-3-yl)(morpholin-4-yl)methanone
CAS 53062-98-9C10H11ClN2O2
(2,6-Dimethylmorpholino)[2-methyl-6-(trifluoromethyl)pyridin-3-yl]methanone chemical structure, C14H17F3N2O2, CAS 646455-66-5
(2,6-Dimethylmorpholino)[2-methyl-6-(trifluoromethyl)pyridin-3-yl]methanone
CAS 646455-66-5C14H17F3N2O2
4-[(2,6-Dichloro-5-fluoropyridin-3-yl)carbonyl]morpholine chemical structure, C10H9Cl2FN2O2, CAS 680217-88-3
4-[(2,6-Dichloro-5-fluoropyridin-3-yl)carbonyl]morpholine
CAS 680217-88-3C10H9Cl2FN2O2
4-(5,6-Dichloropyridine-3-carbonyl)morpholine chemical structure, C10H10Cl2N2O2, CAS 919784-85-3
4-(5,6-Dichloropyridine-3-carbonyl)morpholine
CAS 919784-85-3C10H10Cl2N2O2
(6-Chloropyridin-3-yl)(2,6-dimethylmorpholino)methanone chemical structure, C12H15ClN2O2, CAS 1016749-14-6
(6-Chloropyridin-3-yl)(2,6-dimethylmorpholino)methanone
CAS 1016749-14-6C12H15ClN2O2
(2,6-Dimethoxypyridin-3-yl)(morpholino)methanone chemical structure, C12H16N2O4, CAS 933005-75-5
(2,6-Dimethoxypyridin-3-yl)(morpholino)methanone
CAS 933005-75-5C12H16N2O4
2,6-Dimethyl-4-[2-(methylsulfanyl)pyridine-3-carbonyl]morpholine chemical structure, C13H18N2O2S, CAS 1118800-42-2
2,6-Dimethyl-4-[2-(methylsulfanyl)pyridine-3-carbonyl]morpholine
CAS 1118800-42-2C13H18N2O2S
(5-Bromopyridin-3-yl)(2-methylmorpholino)methanone chemical structure, C11H13BrN2O2, CAS 1090519-55-3
(5-Bromopyridin-3-yl)(2-methylmorpholino)methanone
CAS 1090519-55-3C11H13BrN2O2
(6-Chloropyridin-3-yl)(3-methylmorpholino)methanone chemical structure, C11H13ClN2O2, CAS 1153797-93-3
(6-Chloropyridin-3-yl)(3-methylmorpholino)methanone
CAS 1153797-93-3C11H13ClN2O2
4-[2-(Methylsulfanyl)pyridine-3-carbonyl]morpholine chemical structure, C11H14N2O2S, CAS 1211356-64-7
4-[2-(Methylsulfanyl)pyridine-3-carbonyl]morpholine
CAS 1211356-64-7C11H14N2O2S
Morpholino(6-(trifluoromethyl)pyridin-3-yl)methanone chemical structure, C11H11F3N2O2, CAS 1181506-92-2
Morpholino(6-(trifluoromethyl)pyridin-3-yl)methanone
CAS 1181506-92-2C11H11F3N2O2
(5-Bromopyridin-3-yl)(3-methylmorpholino)methanone chemical structure, C11H13BrN2O2, CAS 1306097-16-4
(5-Bromopyridin-3-yl)(3-methylmorpholino)methanone
CAS 1306097-16-4C11H13BrN2O2
4-(2,6-Dichloro-5-fluoropyridine-3-carbonyl)-3,3-dimethylmorpholine chemical structure, C12H13Cl2FN2O2, CAS 1356765-34-8
4-(2,6-Dichloro-5-fluoropyridine-3-carbonyl)-3,3-dimethylmorpholine
CAS 1356765-34-8C12H13Cl2FN2O2
(6-Hydrazineylpyridin-3-yl)(morpholino)methanone chemical structure, C10H14N4O2, CAS 700803-90-3
(6-Hydrazineylpyridin-3-yl)(morpholino)methanone
CAS 700803-90-3C10H14N4O2
(6-Aminopyridin-3-yl)(morpholino)methanone chemical structure, C10H13N3O2, CAS 827587-90-6
(6-Aminopyridin-3-yl)(morpholino)methanone
CAS 827587-90-6C10H13N3O2
(5-Bromo-2-chloropyridin-3-yl)(morpholino)methanone chemical structure, C10H10BrClN2O2, CAS 1251232-44-6
(5-Bromo-2-chloropyridin-3-yl)(morpholino)methanone
CAS 1251232-44-6C10H10BrClN2O2
(6-Aminopyridin-3-yl)(2,6-dimethylmorpholino)methanone chemical structure, C12H17N3O2, CAS 1460263-55-1
(6-Aminopyridin-3-yl)(2,6-dimethylmorpholino)methanone
CAS 1460263-55-1C12H17N3O2
(2-Amino-3-pyridyl)(morpholino)methanone chemical structure, C10H13N3O2, CAS 1248775-87-2
(2-Amino-3-pyridyl)(morpholino)methanone
CAS 1248775-87-2C10H13N3O2
(6-Bromopyridin-3-yl)(morpholino)methanone chemical structure, C10H11BrN2O2, CAS 1180131-60-5
(6-Bromopyridin-3-yl)(morpholino)methanone
CAS 1180131-60-5C10H11BrN2O2